BRD-K65182930_NVP-AUY922_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

202 genes differentially expressed following the BRD-K65182930_NVP-AUY922_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AFF1 AF4/FMR2 family, member 1
AGR2 anterior gradient 2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANGPT1 angiopoietin 1
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BAG3 BCL2-associated athanogene 3
BCHE butyrylcholinesterase
BID BH3 interacting domain death agonist
C6ORF48 chromosome 6 open reading frame 48
CALB1 calbindin 1, 28kDa
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CDK19 cyclin-dependent kinase 19
CLEC3B C-type lectin domain family 3, member B
COL4A5 collagen, type IV, alpha 5
CRYAB crystallin, alpha B
CST3 cystatin C
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EIF4B eukaryotic translation initiation factor 4B
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERMP1 endoplasmic reticulum metallopeptidase 1
F13A1 coagulation factor XIII, A1 polypeptide
FAM53C family with sequence similarity 53, member C
FXR1 fragile X mental retardation, autosomal homolog 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
GRB14 growth factor receptor-bound protein 14
GREB1 growth regulation by estrogen in breast cancer 1
GSTA1 glutathione S-transferase alpha 1
HMOX1 heme oxygenase 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
KLHL24 kelch-like family member 24
LRRC16A leucine rich repeat containing 16A
MAOA monoamine oxidase A
MAOB monoamine oxidase B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MME membrane metallo-endopeptidase
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYL9 myosin, light chain 9, regulatory
N4BP2L2 NEDD4 binding protein 2-like 2
NEB nebulin
NEBL nebulette
NPR3 natriuretic peptide receptor 3
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PBX1 pre-B-cell leukemia homeobox 1
PCDH9 protocadherin 9
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZD8 PDZ domain containing 8
PEG3 paternally expressed 3
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCB4 phospholipase C, beta 4
PROM1 prominin 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RABGAP1 RAB GTPase activating protein 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS2 regulator of G-protein signaling 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC31A SEC31 homolog A (S. cerevisiae)
SEPP1 selenoprotein P, plasma, 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOX2 SRY (sex determining region Y)-box 2
SYT1 synaptotagmin I
TARP TCR gamma alternate reading frame protein
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TNNC1 troponin C type 1 (slow)
TNS1 tensin 1
TSPYL5 TSPY-like 5
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VDAC1 voltage-dependent anion channel 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5 arachidonate 5-lipoxygenase
ARL4C ADP-ribosylation factor-like 4C
ASF1B anti-silencing function 1B histone chaperone
BHLHE40 basic helix-loop-helix family, member e40
BRCA1 breast cancer 1, early onset
CARD10 caspase recruitment domain family, member 10
CCL2 chemokine (C-C motif) ligand 2
CCNE2 cyclin E2
CD24 CD24 molecule
CD69 CD69 molecule
CD9 CD9 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA4 cell division cycle associated 4
CDK14 cyclin-dependent kinase 14
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDT1 chromatin licensing and DNA replication factor 1
CENPU centromere protein U
CKLF chemokine-like factor
COTL1 coactosin-like F-actin binding protein 1
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL14 chemokine (C-X-C motif) ligand 14
DHFR dihydrofolate reductase
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
EDNRA endothelin receptor type A
EFHD2 EF-hand domain family, member D2
EGFR epidermal growth factor receptor
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
EXT1 exostosin glycosyltransferase 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNG12 guanine nucleotide binding protein (G protein), gamma 12
HELLS helicase, lymphoid-specific
HNMT histamine N-methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IGFBP3 insulin-like growth factor binding protein 3
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
ITGA6 integrin, alpha 6
JUN jun proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KLF4 Kruppel-like factor 4 (gut)
L1CAM L1 cell adhesion molecule
LGALS1 lectin, galactoside-binding, soluble, 1
LIG1 ligase I, DNA, ATP-dependent
LTF lactotransferrin
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MET MET proto-oncogene, receptor tyrosine kinase
MMP7 matrix metallopeptidase 7
MT2A metallothionein 2A
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOF myoferlin
OLFM4 olfactomedin 4
OSBPL10 oxysterol binding protein-like 10
PCNA proliferating cell nuclear antigen
PDE4A phosphodiesterase 4A, cAMP-specific
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLK2 polo-like kinase 2
PNMA2 paraneoplastic Ma antigen 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCA protein kinase C, alpha
PRKD3 protein kinase D3
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB27A RAB27A, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RPA3 replication protein A3, 14kDa
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
S100A6 S100 calcium binding protein A6
SH2B3 SH2B adaptor protein 3
SOX9 SRY (sex determining region Y)-box 9
SPON1 spondin 1, extracellular matrix protein
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFDP1 transcription factor Dp-1
TK1 thymidine kinase 1, soluble
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TRMT5 tRNA methyltransferase 5
TUBA4A tubulin, alpha 4a
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
ZCCHC24 zinc finger, CCHC domain containing 24
ZFP36L1 ZFP36 ring finger protein-like 1
Funding