BRD-K65182930_NVP-AUY922_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

220 genes differentially expressed following the BRD-K65182930_NVP-AUY922_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AFF1 AF4/FMR2 family, member 1
AGR2 anterior gradient 2
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AQP3 aquaporin 3 (Gill blood group)
ASS1 argininosuccinate synthase 1
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
BEX4 brain expressed, X-linked 4
BPIFA1 BPI fold containing family A, member 1
C1ORF115 chromosome 1 open reading frame 115
C1QB complement component 1, q subcomponent, B chain
C8ORF4 chromosome 8 open reading frame 4
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD163 CD163 molecule
CD99 CD99 molecule
CES1 carboxylesterase 1
CGA glycoprotein hormones, alpha polypeptide
CLU clusterin
COL4A5 collagen, type IV, alpha 5
CPNE3 copine III
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRABP1 cellular retinoic acid binding protein 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CRELD2 cysteine-rich with EGF-like domains 2
CXCL13 chemokine (C-X-C motif) ligand 13
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
EIF4B eukaryotic translation initiation factor 4B
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB4 erb-b2 receptor tyrosine kinase 4
ERMP1 endoplasmic reticulum metallopeptidase 1
FAM171A1 family with sequence similarity 171, member A1
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
KDM5B lysine (K)-specific demethylase 5B
KLHL24 kelch-like family member 24
KLHL9 kelch-like family member 9
KRT13 keratin 13, type I
KRT5 keratin 5, type II
LPL lipoprotein lipase
LRRC16A leucine rich repeat containing 16A
MAL mal, T-cell differentiation protein
MAOA monoamine oxidase A
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEF2C myocyte enhancer factor 2C
MSMB microseminoprotein, beta-
MYL9 myosin, light chain 9, regulatory
NFE2L1 nuclear factor, erythroid 2-like 1
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDIA3 protein disulfide isomerase family A, member 3
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIR pirin (iron-binding nuclear protein)
PLA1A phospholipase A1 member A
PLTP phospholipid transfer protein
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRSS23 protease, serine, 23
QPRT quinolinate phosphoribosyltransferase
RANBP2 RAN binding protein 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS2 regulator of G-protein signaling 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB1 SATB homeobox 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC31A SEC31 homolog A (S. cerevisiae)
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SSR4 signal sequence receptor, delta
STAB1 stabilin 1
TSPYL5 TSPY-like 5
TUSC3 tumor suppressor candidate 3
UGDH UDP-glucose 6-dehydrogenase
USP9X ubiquitin specific peptidase 9, X-linked
VWF von Willebrand factor
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AK4 adenylate kinase 4
ALOX5 arachidonate 5-lipoxygenase
ANXA1 annexin A1
ANXA3 annexin A3
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARL4C ADP-ribosylation factor-like 4C
BHLHE40 basic helix-loop-helix family, member e40
C1ORF106 chromosome 1 open reading frame 106
CA2 carbonic anhydrase II
CAPN2 calpain 2, (m/II) large subunit
CARD10 caspase recruitment domain family, member 10
CCDC109B coiled-coil domain containing 109B
CCL2 chemokine (C-C motif) ligand 2
CCP110 centriolar coiled coil protein 110kDa
CD9 CD9 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDCA4 cell division cycle associated 4
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDT1 chromatin licensing and DNA replication factor 1
CENPU centromere protein U
CKLF chemokine-like factor
DEK DEK proto-oncogene
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DPY19L2P2 DPY19L2 pseudogene 2
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EGFR epidermal growth factor receptor
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
EREG epiregulin
ETV1 ets variant 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FKBP14 FK506 binding protein 14, 22 kDa
FOSL1 FOS-like antigen 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMNN geminin, DNA replication inhibitor
GSAP gamma-secretase activating protein
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IGFBP3 insulin-like growth factor binding protein 3
IL13RA2 interleukin 13 receptor, alpha 2
ITGA6 integrin, alpha 6
ITGB4 integrin, beta 4
JUN jun proto-oncogene
KAT2B K(lysine) acetyltransferase 2B
KIAA1033 KIAA1033
LAMC2 laminin, gamma 2
LSP1 lymphocyte-specific protein 1
LTF lactotransferrin
LYPD1 LY6/PLAUR domain containing 1
MAPK9 mitogen-activated protein kinase 9
MATN2 matrilin 2
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MET MET proto-oncogene, receptor tyrosine kinase
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MMP7 matrix metallopeptidase 7
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOF myoferlin
MYRF myelin regulatory factor
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
OSBPL10 oxysterol binding protein-like 10
PCNA proliferating cell nuclear antigen
PFKL phosphofructokinase, liver
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLBD1 phospholipase B domain containing 1
PLK2 polo-like kinase 2
PNMA2 paraneoplastic Ma antigen 2
POLD3 polymerase (DNA-directed), delta 3, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCA protein kinase C, alpha
PRSS3 protease, serine, 3
PXMP2 peroxisomal membrane protein 2, 22kDa
PXN paxillin
RAB31 RAB31, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A12 S100 calcium binding protein A12
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SOX11 SRY (sex determining region Y)-box 11
SOX9 SRY (sex determining region Y)-box 9
SPON1 spondin 1, extracellular matrix protein
SPRY2 sprouty homolog 2 (Drosophila)
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TEAD4 TEA domain family member 4
TGFBI transforming growth factor, beta-induced, 68kDa
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
UNG uracil-DNA glycosylase
USP1 ubiquitin specific peptidase 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
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