BRD-K65182930_NVP-AUY922_HS578T_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

245 genes differentially expressed following the BRD-K65182930_NVP-AUY922_HS578T_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADI1 acireductone dioxygenase 1
AFF1 AF4/FMR2 family, member 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BBX bobby sox homolog (Drosophila)
BID BH3 interacting domain death agonist
BLVRA biliverdin reductase A
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CCNB2 cyclin B2
CCNG1 cyclin G1
CCNG2 cyclin G2
CD99 CD99 molecule
CDK1 cyclin-dependent kinase 1
CDK19 cyclin-dependent kinase 19
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CENPE centromere protein E, 312kDa
CES1 carboxylesterase 1
CHN1 chimerin 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKS2 CDC28 protein kinase regulatory subunit 2
COBL cordon-bleu WH2 repeat protein
CRABP1 cellular retinoic acid binding protein 1
CRYZ crystallin, zeta (quinone reductase)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL13 chemokine (C-X-C motif) ligand 13
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSG2 desmoglein 2
EGF epidermal growth factor
EIF3F eukaryotic translation initiation factor 3, subunit F
EMP2 epithelial membrane protein 2
FTO fat mass and obesity associated
FXR1 fragile X mental retardation, autosomal homolog 1
GAS1 growth arrest-specific 1
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GOLGB1 golgin B1
GOLM1 golgi membrane protein 1
GPC3 glypican 3
GPR143 G protein-coupled receptor 143
HACD2 3-hydroxyacyl-CoA dehydratase 2
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
JMJD6 jumonji domain containing 6
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LDHB lactate dehydrogenase B
LEF1 lymphoid enhancer-binding factor 1
MAGED2 melanoma antigen family D2
MAOA monoamine oxidase A
NDRG1 N-myc downstream regulated 1
NEBL nebulette
NID2 nidogen 2 (osteonidogen)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUSAP1 nucleolar and spindle associated protein 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PDCD2 programmed cell death 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIP prolactin-induced protein
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PRDX2 peroxiredoxin 2
PRKD2 protein kinase D2
PTOV1 prostate tumor overexpressed 1
PTTG1 pituitary tumor-transforming 1
QKI QKI, KH domain containing, RNA binding
QPRT quinolinate phosphoribosyltransferase
RGS5 regulator of G-protein signaling 5
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SEPT6 septin 6
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD3 SMAD family member 3
SOD1 superoxide dismutase 1, soluble
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STK26 serine/threonine protein kinase 26
SV2C synaptic vesicle glycoprotein 2C
TMEM45A transmembrane protein 45A
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAPPC2 trafficking protein particle complex 2
TSPAN13 tetraspanin 13
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WFS1 Wolfram syndrome 1 (wolframin)
XIST X inactive specific transcript (non-protein coding)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C10ORF10 chromosome 10 open reading frame 10
CALML5 calmodulin-like 5
CCDC85B coiled-coil domain containing 85B
CCND1 cyclin D1
CCNE2 cyclin E2
CD36 CD36 molecule (thrombospondin receptor)
CD3EAP CD3e molecule, epsilon associated protein
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COMP cartilage oligomeric matrix protein
CST6 cystatin E/M
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DCLK1 doublecortin-like kinase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP6 dual specificity phosphatase 6
E2F2 E2F transcription factor 2
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
EPS8 epidermal growth factor receptor pathway substrate 8
EREG epiregulin
ETV1 ets variant 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FGFR2 fibroblast growth factor receptor 2
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FST follistatin
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAP43 growth associated protein 43
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GEM GTP binding protein overexpressed in skeletal muscle
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HES1 hes family bHLH transcription factor 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
INHBA inhibin, beta A
ISG15 ISG15 ubiquitin-like modifier
JAG1 jagged 1
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT23 keratin 23, type I
LMCD1 LIM and cysteine-rich domains 1
LMO4 LIM domain only 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1C1 mannosidase, alpha, class 1C, member 1
MAP7 microtubule-associated protein 7
MCL1 myeloid cell leukemia 1
MET MET proto-oncogene, receptor tyrosine kinase
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MGLL monoglyceride lipase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP19 matrix metallopeptidase 19
MMP7 matrix metallopeptidase 7
MRPL57 mitochondrial ribosomal protein L57
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTCL1 microtubule crosslinking factor 1
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTSS1 metastasis suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
NREP neuronal regeneration related protein
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
OSBPL10 oxysterol binding protein-like 10
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCOLCE2 procollagen C-endopeptidase enhancer 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEA15 phosphoprotein enriched in astrocytes 15
PER2 period circadian clock 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PNP purine nucleoside phosphorylase
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRSS2 protease, serine, 2 (trypsin 2)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RAD23B RAD23 homolog B (S. cerevisiae)
RBBP8 retinoblastoma binding protein 8
REG1A regenerating islet-derived 1 alpha
RFTN1 raftlin, lipid raft linker 1
RIN2 Ras and Rab interactor 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SDC4 syndecan 4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SNAI2 snail family zinc finger 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRPX sushi-repeat containing protein, X-linked
STAB1 stabilin 1
STK38L serine/threonine kinase 38 like
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
THBD thrombomodulin
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TSPAN4 tetraspanin 4
UNG uracil-DNA glycosylase
UPP1 uridine phosphorylase 1
VTCN1 V-set domain containing T cell activation inhibitor 1
Funding