BRD-K65182930_NVP-AUY922_MCF10A_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K65182930_NVP-AUY922_MCF10A_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AKR1C1 aldo-keto reductase family 1, member C1
AQP4 aquaporin 4
BAG3 BCL2-associated athanogene 3
CACYBP calcyclin binding protein
CBR3 carbonyl reductase 3
CD40 CD40 molecule, TNF receptor superfamily member 5
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHI3L2 chitinase 3-like 2
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CRYAB crystallin, alpha B
CXCL8 chemokine (C-X-C motif) ligand 8
DEFB1 defensin, beta 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
EGLN3 egl-9 family hypoxia-inducible factor 3
FGFR2 fibroblast growth factor receptor 2
GJA1 gap junction protein, alpha 1, 43kDa
GPX3 glutathione peroxidase 3
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IFI27 interferon, alpha-inducible protein 27
INHBB inhibin, beta B
JMJD6 jumonji domain containing 6
LOX lysyl oxidase
MATN2 matrilin 2
MSX1 msh homeobox 1
NMB neuromedin B
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
QPRT quinolinate phosphoribosyltransferase
TMEM100 transmembrane protein 100
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AIM1 absent in melanoma 1
APOD apolipoprotein D
AREG amphiregulin
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CREB1 cAMP responsive element binding protein 1
CYR61 cysteine-rich, angiogenic inducer, 61
DSE dermatan sulfate epimerase
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EPHA3 EPH receptor A3
EREG epiregulin
F13A1 coagulation factor XIII, A1 polypeptide
FAM65B family with sequence similarity 65, member B
FAP fibroblast activation protein, alpha
FLRT2 fibronectin leucine rich transmembrane protein 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
GAS1 growth arrest-specific 1
HMGA2 high mobility group AT-hook 2
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
IL1A interleukin 1, alpha
IL7R interleukin 7 receptor
ITGA6 integrin, alpha 6
JADE2 jade family PHD finger 2
LY6E lymphocyte antigen 6 complex, locus E
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MN1 meningioma (disrupted in balanced translocation) 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPIPB3 nuclear pore complex interacting protein family, member B3
NT5E 5'-nucleotidase, ecto (CD73)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAC8 placenta-specific 8
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
RGS1 regulator of G-protein signaling 1
S100A8 S100 calcium binding protein A8
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A1 solute carrier family 38, member 1
SPP1 secreted phosphoprotein 1
TES testin LIM domain protein
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLK2 tousled-like kinase 2
TLR2 toll-like receptor 2
TPSAB1 tryptase alpha/beta 1
WEE1 WEE1 G2 checkpoint kinase
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
Funding