BRD-K65182930_NVP-AUY922_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

227 genes differentially expressed following the BRD-K65182930_NVP-AUY922_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABHD4 abhydrolase domain containing 4
ADGRG6 adhesion G protein-coupled receptor G6
ADM adrenomedullin
AFF1 AF4/FMR2 family, member 1
APOD apolipoprotein D
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATP9A ATPase, class II, type 9A
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BBX bobby sox homolog (Drosophila)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTN3A2 butyrophilin, subfamily 3, member A2
C1QB complement component 1, q subcomponent, B chain
C6ORF48 chromosome 6 open reading frame 48
CCDC28A coiled-coil domain containing 28A
CCNG1 cyclin G1
CCNG2 cyclin G2
CD163 CD163 molecule
CDK19 cyclin-dependent kinase 19
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CGA glycoprotein hormones, alpha polypeptide
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN10 claudin 10
COBL cordon-bleu WH2 repeat protein
COL1A1 collagen, type I, alpha 1
CRYZ crystallin, zeta (quinone reductase)
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAZAP2 DAZ associated protein 2
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EFCAB14 EF-hand calcium binding domain 14
EFNB2 ephrin-B2
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FAM13A family with sequence similarity 13, member A
FAM46A family with sequence similarity 46, member A
FN1 fibronectin 1
FOXJ3 forkhead box J3
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GATA2 GATA binding protein 2
GLUL glutamate-ammonia ligase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLGB1 golgin B1
GOLPH3L golgi phosphoprotein 3-like
GPNMB glycoprotein (transmembrane) nmb
HBP1 HMG-box transcription factor 1
HLA-E major histocompatibility complex, class I, E
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGN3 high mobility group nucleosomal binding domain 3
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
KLHDC10 kelch domain containing 10
KLHL24 kelch-like family member 24
LDHB lactate dehydrogenase B
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LPGAT1 lysophosphatidylglycerol acyltransferase 1
MAOA monoamine oxidase A
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MKRN1 makorin ring finger protein 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MXI1 MAX interactor 1, dimerization protein
NBR1 neighbor of BRCA1 gene 1
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
OBSL1 obscurin-like 1
OSR2 odd-skipped related transciption factor 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEG10 paternally expressed 10
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRSS8 protease, serine, 8
QPRT quinolinate phosphoribosyltransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RELN reelin
SC5D sterol-C5-desaturase
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDCBP syndecan binding protein (syntenin)
SFRP1 secreted frizzled-related protein 1
SGCE sarcoglycan, epsilon
SKAP2 src kinase associated phosphoprotein 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STATH statherin
STC1 stanniocalcin 1
STOM stomatin
SYT1 synaptotagmin I
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TPSAB1 tryptase alpha/beta 1
TSC22D1 TSC22 domain family, member 1
TWIST1 twist family bHLH transcription factor 1
TXNIP thioredoxin interacting protein
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ANXA5 annexin A5
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BYSL bystin-like
CCDC85B coiled-coil domain containing 85B
CCND1 cyclin D1
CCNE2 cyclin E2
CD58 CD58 molecule
CD69 CD69 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPU centromere protein U
CKLF chemokine-like factor
CLIC3 chloride intracellular channel 3
CLTB clathrin, light chain B
CSTA cystatin A (stefin A)
CXCL14 chemokine (C-X-C motif) ligand 14
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DESI1 desumoylating isopeptidase 1
DGKZ diacylglycerol kinase, zeta
DHFR dihydrofolate reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFS embryonal Fyn-associated substrate
EGR3 early growth response 3
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EREG epiregulin
EXOSC2 exosome component 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F12 coagulation factor XII (Hageman factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FEN1 flap structure-specific endonuclease 1
GALE UDP-galactose-4-epimerase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLRX2 glutaredoxin 2
HN1 hematological and neurological expressed 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
ICAM3 intercellular adhesion molecule 3
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IPO4 importin 4
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KLF4 Kruppel-like factor 4 (gut)
KRT16 keratin 16, type I
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
LOXL1 lysyl oxidase-like 1
LRRC17 leucine rich repeat containing 17
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MREG melanoregulin
MRPL15 mitochondrial ribosomal protein L15
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOP16 NOP16 nucleolar protein
NQO2 NAD(P)H dehydrogenase, quinone 2
NXT1 nuclear transport factor 2-like export factor 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCNA proliferating cell nuclear antigen
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRR7 proline rich 7 (synaptic)
PYCR1 pyrroline-5-carboxylate reductase 1
RANBP1 RAN binding protein 1
RBBP8 retinoblastoma binding protein 8
RFC2 replication factor C (activator 1) 2, 40kDa
RNASEH2A ribonuclease H2, subunit A
RPP40 ribonuclease P/MRP 40kDa subunit
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUFY3 RUN and FYVE domain containing 3
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCML1 sex comb on midleg-like 1 (Drosophila)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPRED2 sprouty-related, EVH1 domain containing 2
SRM spermidine synthase
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIPIN TIMELESS interacting protein
TLR4 toll-like receptor 4
TMEM126B transmembrane protein 126B
TMEM251 transmembrane protein 251
TMEM5 transmembrane protein 5
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBG1 tubulin, gamma 1
Funding