BRD-K65182930_NVP-AUY922_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-K65182930_NVP-AUY922_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP9 A kinase (PRKA) anchor protein 9
BAG3 BCL2-associated athanogene 3
BST2 bone marrow stromal cell antigen 2
C9ORF3 chromosome 9 open reading frame 3
CAST calpastatin
CD59 CD59 molecule, complement regulatory protein
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHI3L2 chitinase 3-like 2
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ERAP1 endoplasmic reticulum aminopeptidase 1
FKBP11 FK506 binding protein 11, 19 kDa
GLRX glutaredoxin (thioltransferase)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF1 insulin-like growth factor 1 (somatomedin C)
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
MAL mal, T-cell differentiation protein
MEIS1 Meis homeobox 1
MX1 MX dynamin-like GTPase 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PLCB4 phospholipase C, beta 4
PLSCR1 phospholipid scramblase 1
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERP1 stress-associated endoplasmic reticulum protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLPI secretory leukocyte peptidase inhibitor
STAT1 signal transducer and activator of transcription 1, 91kDa
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AREG amphiregulin
ASPN asporin
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCND2 cyclin D2
COL1A2 collagen, type I, alpha 2
EPCAM epithelial cell adhesion molecule
FST follistatin
GDF15 growth differentiation factor 15
GSTM3 glutathione S-transferase mu 3 (brain)
HES1 hes family bHLH transcription factor 1
HHEX hematopoietically expressed homeobox
IER3 immediate early response 3
MARCKSL1 MARCKS-like 1
MGP matrix Gla protein
NQO1 NAD(P)H dehydrogenase, quinone 1
NRN1 neuritin 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMP22 peripheral myelin protein 22
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPP1 secreted phosphoprotein 1
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB3 tribbles pseudokinase 3
TSPAN4 tetraspanin 4
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
Funding