BRD-K65786282_-666_NPC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K65786282_-666_NPC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCY1 adenylate cyclase 1 (brain)
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ARMCX3 armadillo repeat containing, X-linked 3
BBX bobby sox homolog (Drosophila)
BST2 bone marrow stromal cell antigen 2
C2CD5 C2 calcium-dependent domain containing 5
CCL19 chemokine (C-C motif) ligand 19
CDK4 cyclin-dependent kinase 4
CHL1 cell adhesion molecule L1-like
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CST3 cystatin C
CXCL12 chemokine (C-X-C motif) ligand 12
EGR2 early growth response 2
ETNK1 ethanolamine kinase 1
FGFR3 fibroblast growth factor receptor 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLDC glycine dehydrogenase (decarboxylating)
HDGFRP3 hepatoma-derived growth factor, related protein 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT14 keratin 14, type I
LMO2 LIM domain only 2 (rhombotin-like 1)
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAP1B microtubule-associated protein 1B
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MCAM melanoma cell adhesion molecule
MFSD10 major facilitator superfamily domain containing 10
MT2A metallothionein 2A
NCK2 NCK adaptor protein 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM4 olfactomedin 4
OXTR oxytocin receptor
PCTP phosphatidylcholine transfer protein
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
RHOBTB3 Rho-related BTB domain containing 3
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
TFPI2 tissue factor pathway inhibitor 2
TMEM47 transmembrane protein 47
TOP2A topoisomerase (DNA) II alpha 170kDa
VCAM1 vascular cell adhesion molecule 1
XPO7 exportin 7

decreased expression

Symbol Name
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX5 arachidonate 5-lipoxygenase
ASS1 argininosuccinate synthase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C1ORF116 chromosome 1 open reading frame 116
CADM1 cell adhesion molecule 1
CCNE2 cyclin E2
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
COL11A1 collagen, type XI, alpha 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
EGFL6 EGF-like-domain, multiple 6
FHOD3 formin homology 2 domain containing 3
FXYD3 FXYD domain containing ion transport regulator 3
GAGE3 G antigen 3
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IGL immunoglobulin lambda locus
IRS2 insulin receptor substrate 2
KLK10 kallikrein-related peptidase 10
KLK5 kallikrein-related peptidase 5
LCN2 lipocalin 2
MRPS16 mitochondrial ribosomal protein S16
PDZK1IP1 PDZK1 interacting protein 1
PLK2 polo-like kinase 2
PPAP2A phosphatidic acid phosphatase type 2A
PPOX protoporphyrinogen oxidase
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RGCC regulator of cell cycle
RTN2 reticulon 2
S100A9 S100 calcium binding protein A9
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SOD2 superoxide dismutase 2, mitochondrial
TMC5 transmembrane channel-like 5
TP53I3 tumor protein p53 inducible protein 3
VTCN1 V-set domain containing T cell activation inhibitor 1
YBX3 Y box binding protein 3
ZNF395 zinc finger protein 395
Funding