BRD-K65814004_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-K65814004_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRL2 adhesion G protein-coupled receptor L2
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD10 ankyrin repeat domain 10
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C7 complement component 7
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CES1 carboxylesterase 1
CLIP2 CAP-GLY domain containing linker protein 2
COCH cochlin
CTGF connective tissue growth factor
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
FDXR ferredoxin reductase
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLC glutamate-cysteine ligase, catalytic subunit
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
GPR87 G protein-coupled receptor 87
GPX3 glutathione peroxidase 3
HBEGF heparin-binding EGF-like growth factor
HMOX1 heme oxygenase 1
IER5 immediate early response 5
KRT5 keratin 5, type II
LAMP3 lysosomal-associated membrane protein 3
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGLL monoglyceride lipase
MSMB microseminoprotein, beta-
NOTCH1 notch 1
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RND3 Rho family GTPase 3
RPS27L ribosomal protein S27-like
RRAD Ras-related associated with diabetes
RUNX3 runt-related transcription factor 3
SFN stratifin
THSD7A thrombospondin, type I, domain containing 7A
TUBB2A tubulin, beta 2A class IIa
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ASS1 argininosuccinate synthase 1
CD24 CD24 molecule
CDC25B cell division cycle 25B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC5A C-type lectin domain family 5, member A
COL8A2 collagen, type VIII, alpha 2
DUOX2 dual oxidase 2
ERLIN1 ER lipid raft associated 1
FCGBP Fc fragment of IgG binding protein
GNAS GNAS complex locus
HHEX hematopoietically expressed homeobox
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HK2 hexokinase 2
HOOK2 hook microtubule-tethering protein 2
IGFBP5 insulin-like growth factor binding protein 5
LDOC1 leucine zipper, down-regulated in cancer 1
MT1F metallothionein 1F
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SMAD1 SMAD family member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM243 transmembrane protein 243, mitochondrial
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
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