BRD-K65904652_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

69 genes differentially expressed following the BRD-K65904652_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ASRGL1 asparaginase like 1
BASP1 brain abundant, membrane attached signal protein 1
BDNF brain-derived neurotrophic factor
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42 cell division cycle 42
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CTGF connective tissue growth factor
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FHL1 four and a half LIM domains 1
GBP1 guanylate binding protein 1, interferon-inducible
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LOC100505650 uncharacterized LOC100505650
LXN latexin
LYZ lysozyme
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MMP7 matrix metallopeptidase 7
NNMT nicotinamide N-methyltransferase
PRUNE2 prune homolog 2 (Drosophila)
QPCT glutaminyl-peptide cyclotransferase
RAB3B RAB3B, member RAS oncogene family
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
SCGB2A1 secretoglobin, family 2A, member 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORBS2 sorbin and SH3 domain containing 2
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRGN serglycin
TLR4 toll-like receptor 4
TMEM14A transmembrane protein 14A
TPD52L1 tumor protein D52-like 1
VCAN versican
VNN1 vanin 1

decreased expression

Symbol Name
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
COL6A2 collagen, type VI, alpha 2
EDNRA endothelin receptor type A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GNAS GNAS complex locus
GPM6B glycoprotein M6B
GRB7 growth factor receptor-bound protein 7
HSPA1A heat shock 70kDa protein 1A
IFITM1 interferon induced transmembrane protein 1
IGL immunoglobulin lambda locus
KRT5 keratin 5, type II
MAT2A methionine adenosyltransferase II, alpha
MT1G metallothionein 1G
MT1X metallothionein 1X
PLTP phospholipid transfer protein
PRRC2C proline-rich coiled-coil 2C
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SETBP1 SET binding protein 1
SPRR1B small proline-rich protein 1B
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)