BRD-K65955264_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K65955264_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADIRF adipogenesis regulatory factor
ANXA1 annexin A1
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CD40 CD40 molecule, TNF receptor superfamily member 5
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CSTA cystatin A (stefin A)
CTH cystathionine gamma-lyase
DCN decorin
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DOK5 docking protein 5
EVI2A ecotropic viral integration site 2A
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPM6B glycoprotein M6B
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA1A heat shock 70kDa protein 1A
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGKV3-20 immunoglobulin kappa variable 3-20
IL6ST interleukin 6 signal transducer
INHBE inhibin, beta E
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
KLK10 kallikrein-related peptidase 10
KRT23 keratin 23, type I
LGALS4 lectin, galactoside-binding, soluble, 4
LMO4 LIM domain only 4
MARS methionyl-tRNA synthetase
MFAP5 microfibrillar associated protein 5
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PYCR1 pyrroline-5-carboxylate reductase 1
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SST somatostatin
STC2 stanniocalcin 2
TES testin LIM domain protein
TFF1 trefoil factor 1
TM4SF4 transmembrane 4 L six family member 4
TNNT1 troponin T type 1 (skeletal, slow)
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNL4B thioredoxin-like 4B
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UPP1 uridine phosphorylase 1
WARS tryptophanyl-tRNA synthetase
WT1 Wilms tumor 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
AQP3 aquaporin 3 (Gill blood group)
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BICD2 bicaudal D homolog 2 (Drosophila)
CBR3 carbonyl reductase 3
CCNE2 cyclin E2
CLCA2 chloride channel accessory 2
COL4A5 collagen, type IV, alpha 5
COL6A3 collagen, type VI, alpha 3
CTSH cathepsin H
EED embryonic ectoderm development
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FBXW2 F-box and WD repeat domain containing 2
FNBP1 formin binding protein 1
FUCA1 fucosidase, alpha-L- 1, tissue
FZD7 frizzled class receptor 7
HIST1H2BK histone cluster 1, H2bk
JADE2 jade family PHD finger 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM5D lysine (K)-specific demethylase 5D
LYN LYN proto-oncogene, Src family tyrosine kinase
MAN1C1 mannosidase, alpha, class 1C, member 1
MERTK MER proto-oncogene, tyrosine kinase
MLEC malectin
MTCL1 microtubule crosslinking factor 1
MTSS1 metastasis suppressor 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
NT5DC2 5'-nucleotidase domain containing 2
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PNISR PNN-interacting serine/arginine-rich protein
RBPMS RNA binding protein with multiple splicing
RERE arginine-glutamic acid dipeptide (RE) repeats
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPTSSA serine palmitoyltransferase, small subunit A
SRPX sushi-repeat containing protein, X-linked
STOM stomatin
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TJP2 tight junction protein 2
TMEM2 transmembrane protein 2
TNC tenascin C
TUBB4B tubulin, beta 4B class IVb