BRD-K65955264_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-K65955264_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
ARMCX2 armadillo repeat containing, X-linked 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AUTS2 autism susceptibility candidate 2
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
CD40 CD40 molecule, TNF receptor superfamily member 5
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLEC11A C-type lectin domain family 11, member A
CPE carboxypeptidase E
CTGF connective tissue growth factor
CXCL5 chemokine (C-X-C motif) ligand 5
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DPYSL2 dihydropyrimidinase-like 2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FST follistatin
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
IL1R1 interleukin 1 receptor, type I
KLF6 Kruppel-like factor 6
KRT23 keratin 23, type I
LGALS4 lectin, galactoside-binding, soluble, 4
LITAF lipopolysaccharide-induced TNF factor
LMCD1 LIM and cysteine-rich domains 1
LYZ lysozyme
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAP1L1 nucleosome assembly protein 1-like 1
NFIL3 nuclear factor, interleukin 3 regulated
NPTX2 neuronal pentraxin II
PAWR PRKC, apoptosis, WT1, regulator
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
PTGDS prostaglandin D2 synthase 21kDa (brain)
PXDN peroxidasin
RGCC regulator of cell cycle
RHOB ras homolog family member B
S100P S100 calcium binding protein P
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SULF1 sulfatase 1
TBX3 T-box 3
TOX3 TOX high mobility group box family member 3
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
ZHX2 zinc fingers and homeoboxes 2
ZNF131 zinc finger protein 131

decreased expression

Symbol Name
AGR2 anterior gradient 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CA12 carbonic anhydrase XII
CDC25A cell division cycle 25A
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLCA2 chloride channel accessory 2
CLU clusterin
EXOSC4 exosome component 4
FAM3C family with sequence similarity 3, member C
GSTP1 glutathione S-transferase pi 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HN1 hematological and neurological expressed 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MALL mal, T-cell differentiation protein-like
MEIS2 Meis homeobox 2
MTA1 metastasis associated 1
NUP85 nucleoporin 85kDa
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
SEPW1 selenoprotein W, 1
SLPI secretory leukocyte peptidase inhibitor
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TSPAN3 tetraspanin 3
TSPAN7 tetraspanin 7
VCAN versican
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