BRD-K66254772_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-K66254772_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BLVRB biliverdin reductase B
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD163 CD163 molecule
CD200 CD200 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLDN10 claudin 10
CLU clusterin
COL6A1 collagen, type VI, alpha 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ELANE elastase, neutrophil expressed
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EREG epiregulin
EZR ezrin
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GLUL glutamate-ammonia ligase
GSTT1 glutathione S-transferase theta 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2BFS H2B histone family, member S (pseudogene)
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIC2 hypermethylated in cancer 2
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER5 immediate early response 5
IGHD immunoglobulin heavy constant delta
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLK10 kallikrein-related peptidase 10
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MOSPD1 motile sperm domain containing 1
MUC4 mucin 4, cell surface associated
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POPDC3 popeye domain containing 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
RGCC regulator of cell cycle
RSRC2 arginine/serine-rich coiled-coil 2
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB1 SATB homeobox 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SIK1 salt-inducible kinase 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TGFBI transforming growth factor, beta-induced, 68kDa
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
ZFP36 ZFP36 ring finger protein
ZNF430 zinc finger protein 430

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AURKB aurora kinase B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B3GNT1
BAMBI BMP and activin membrane-bound inhibitor
CANT1 calcium activated nucleotidase 1
CCNE2 cyclin E2
CCNG2 cyclin G2
CD36 CD36 molecule (thrombospondin receptor)
CD58 CD58 molecule
CXCL14 chemokine (C-X-C motif) ligand 14
DLD dihydrolipoamide dehydrogenase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYD dihydropyrimidine dehydrogenase
ERBB4 erb-b2 receptor tyrosine kinase 4
F2R coagulation factor II (thrombin) receptor
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GATA3 GATA binding protein 3
GFRA1 GDNF family receptor alpha 1
HES1 hes family bHLH transcription factor 1
KRT14 keratin 14, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MGP matrix Gla protein
MREG melanoregulin
MYBPC1 myosin binding protein C, slow type
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPY1R neuropeptide Y receptor Y1
NREP neuronal regeneration related protein
PDGFC platelet derived growth factor C
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POSTN periostin, osteoblast specific factor
PSRC1 proline/serine-rich coiled-coil 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SCGB2A2 secretoglobin, family 2A, member 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM164 transmembrane protein 164
TMEM251 transmembrane protein 251
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUBA1A tubulin, alpha 1a
VCAN versican