BRD-K66538826_amuvatinib_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K66538826_amuvatinib_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BHLHE41 basic helix-loop-helix family, member e41
CCNA1 cyclin A1
CCND1 cyclin D1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
DLK1 delta-like 1 homolog (Drosophila)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOS FBJ murine osteosarcoma viral oncogene homolog
GLRX glutaredoxin (thioltransferase)
HK2 hexokinase 2
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL1R2 interleukin 1 receptor, type II
LINC00341 long intergenic non-protein coding RNA 341
MAN1A1 mannosidase, alpha, class 1A, member 1
MUC16 mucin 16, cell surface associated
NID2 nidogen 2 (osteonidogen)
NPTX2 neuronal pentraxin II
PRSS2 protease, serine, 2 (trypsin 2)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
QPCT glutaminyl-peptide cyclotransferase
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPRY4 sprouty homolog 4 (Drosophila)
STC2 stanniocalcin 2
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACKR3 atypical chemokine receptor 3
ACSL3 acyl-CoA synthetase long-chain family member 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BTG1 B-cell translocation gene 1, anti-proliferative
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CALD1 caldesmon 1
CBR3 carbonyl reductase 3
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCR7 chemokine (C-C motif) receptor 7
CFB complement factor B
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
CNN1 calponin 1, basic, smooth muscle
CPE carboxypeptidase E
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL13 chemokine (C-X-C motif) ligand 13
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DCN decorin
DPT dermatopontin
DPYSL3 dihydropyrimidinase-like 3
DSTN destrin (actin depolymerizing factor)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FAM129A family with sequence similarity 129, member A
FBXO7 F-box protein 7
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GPNMB glycoprotein (transmembrane) nmb
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IL7R interleukin 7 receptor
LCK LCK proto-oncogene, Src family tyrosine kinase
LEF1 lymphoid enhancer-binding factor 1
LTB lymphotoxin beta (TNF superfamily, member 3)
MATN2 matrilin 2
MEIS2 Meis homeobox 2
MGP matrix Gla protein
MTUS1 microtubule associated tumor suppressor 1
MX2 MX dynamin-like GTPase 2
MYH11 myosin, heavy chain 11, smooth muscle
NTS neurotensin
NUPR1 nuclear protein, transcriptional regulator, 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDIA3 protein disulfide isomerase family A, member 3
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLN phospholamban
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SMAD3 SMAD family member 3
SOBP sine oculis binding protein homolog (Drosophila)
SORBS1 sorbin and SH3 domain containing 1
SULF1 sulfatase 1
TDO2 tryptophan 2,3-dioxygenase
TGFBR3 transforming growth factor, beta receptor III
USP18 ubiquitin specific peptidase 18
VCAM1 vascular cell adhesion molecule 1
Funding