BRD-K66555411_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-K66555411_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
ALOX5 arachidonate 5-lipoxygenase
ANGPTL4 angiopoietin-like 4
AOC3 amine oxidase, copper containing 3
AP2M1 adaptor-related protein complex 2, mu 1 subunit
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARL4C ADP-ribosylation factor-like 4C
ARMCX2 armadillo repeat containing, X-linked 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BHLHE41 basic helix-loop-helix family, member e41
C1QB complement component 1, q subcomponent, B chain
CA4 carbonic anhydrase IV
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CD163 CD163 molecule
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRDL1 chordin-like 1
CP ceruloplasmin (ferroxidase)
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL14 chemokine (C-X-C motif) ligand 14
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCLK1 doublecortin-like kinase 1
EDN1 endothelin 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EPAS1 endothelial PAS domain protein 1
FABP4 fatty acid binding protein 4, adipocyte
FAM69A family with sequence similarity 69, member A
FCGBP Fc fragment of IgG binding protein
FLT1 fms-related tyrosine kinase 1
FSD1 fibronectin type III and SPRY domain containing 1
G0S2 G0/G1 switch 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GRK5 G protein-coupled receptor kinase 5
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDO1 indoleamine 2,3-dioxygenase 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
INA internexin neuronal intermediate filament protein, alpha
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNK3 potassium channel, two pore domain subfamily K, member 3
KDR kinase insert domain receptor
KRT14 keratin 14, type I
LMO3 LIM domain only 3 (rhombotin-like 2)
LPL lipoprotein lipase
LYPD3 LY6/PLAUR domain containing 3
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha)
MMP10 matrix metallopeptidase 10
MTCL1 microtubule crosslinking factor 1
NEFH neurofilament, heavy polypeptide
NT5E 5'-nucleotidase, ecto (CD73)
NTAN1 N-terminal asparagine amidase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCOLCE2 procollagen C-endopeptidase enhancer 2
PFN2 profilin 2
PLTP phospholipid transfer protein
PPARG peroxisome proliferator-activated receptor gamma
PRKCI protein kinase C, iota
PRKX protein kinase, X-linked
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTN pleiotrophin
PVALB parvalbumin
RBP4 retinol binding protein 4, plasma
RND3 Rho family GTPase 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SATB1 SATB homeobox 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
SNX7 sorting nexin 7
SPARCL1 SPARC-like 1 (hevin)
TAGLN3 transgelin 3
TCF4 transcription factor 4
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TFPI2 tissue factor pathway inhibitor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TRIM29 tripartite motif containing 29
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABLIM1 actin binding LIM protein 1
ALDOB aldolase B, fructose-bisphosphate
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ARG1 arginase 1
BDH2 3-hydroxybutyrate dehydrogenase, type 2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRYL1 crystallin, lambda 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
F3 coagulation factor III (thromboplastin, tissue factor)
FAM198B family with sequence similarity 198, member B
FGF13 fibroblast growth factor 13
FYB FYN binding protein
GSN gelsolin
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KIAA0101 KIAA0101
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LTF lactotransferrin
MAMLD1 mastermind-like domain containing 1
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MGP matrix Gla protein
MGST2 microsomal glutathione S-transferase 2
MYO6 myosin VI
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCOA4 nuclear receptor coactivator 4
NPC2 Niemann-Pick disease, type C2
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RPL31 ribosomal protein L31
RPS11 ribosomal protein S11
SELL selectin L
SET SET nuclear proto-oncogene
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TLR4 toll-like receptor 4
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMED2 transmembrane emp24 domain trafficking protein 2
TPD52L1 tumor protein D52-like 1
UGCG UDP-glucose ceramide glucosyltransferase
ZNF586 zinc finger protein 586
Funding