BRD-K66792149_-666_MCF7_6.0_h_11.1_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K66792149_-666_MCF7_6.0_h_11.1_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALAS2 5'-aminolevulinate synthase 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
CAV1 caveolin 1, caveolae protein, 22kDa
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DNMBP dynamin binding protein
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EMP1 epithelial membrane protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
EREG epiregulin
FABP4 fatty acid binding protein 4, adipocyte
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLC glutamate-cysteine ligase, catalytic subunit
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HPCAL1 hippocalcin-like 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP7 insulin-like growth factor binding protein 7
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRT19 keratin 19, type I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MMP7 matrix metallopeptidase 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NKX3-1 NK3 homeobox 1
NRCAM neuronal cell adhesion molecule
NT5E 5'-nucleotidase, ecto (CD73)
PGD phosphogluconate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROCR protein C receptor, endothelial
RAP1GAP RAP1 GTPase activating protein
RBPMS RNA binding protein with multiple splicing
RGCC regulator of cell cycle
RND3 Rho family GTPase 3
RPS4Y1 ribosomal protein S4, Y-linked 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SFN stratifin
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPARCL1 SPARC-like 1 (hevin)
TBX3 T-box 3
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIM16 tripartite motif containing 16
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
ATF5 activating transcription factor 5
B3GNT1
CDC25A cell division cycle 25A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CP ceruloplasmin (ferroxidase)
CYBA cytochrome b-245, alpha polypeptide
DCN decorin
DHCR24 24-dehydrocholesterol reductase
EED embryonic ectoderm development
EXOSC4 exosome component 4
GAS1 growth arrest-specific 1
HIST1H4C histone cluster 1, H4c
HMGN3 high mobility group nucleosomal binding domain 3
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
IGHM immunoglobulin heavy constant mu
IGLV3-19 immunoglobulin lambda variable 3-19
MCM10 minichromosome maintenance complex component 10
MMP9 matrix metallopeptidase 9
MPZL1 myelin protein zero-like 1
PEG10 paternally expressed 10
PEX11A peroxisomal biogenesis factor 11 alpha
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SFPQ splicing factor proline/glutamine-rich
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOX11 SRY (sex determining region Y)-box 11
SPINK1 serine peptidase inhibitor, Kazal type 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
XBP1 X-box binding protein 1
Funding