BRD-K67075780_TGX-115_HT29_24.0_h_160.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

176 genes differentially expressed following the BRD-K67075780_TGX-115_HT29_24.0_h_160.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACKR3 atypical chemokine receptor 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
APOD apolipoprotein D
ASS1 argininosuccinate synthase 1
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C1ORF106 chromosome 1 open reading frame 106
CD40 CD40 molecule, TNF receptor superfamily member 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
COMP cartilage oligomeric matrix protein
CTSL cathepsin L
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOCK9 dedicator of cytokinesis 9
DSP desmoplakin
DUSP3 dual specificity phosphatase 3
DUSP5 dual specificity phosphatase 5
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ELANE elastase, neutrophil expressed
EPAS1 endothelial PAS domain protein 1
ETHE1 ethylmalonic encephalopathy 1
FADS3 fatty acid desaturase 3
FGFR1 fibroblast growth factor receptor 1
FMOD fibromodulin
FTH1 ferritin, heavy polypeptide 1
FZD6 frizzled class receptor 6
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
IL1R1 interleukin 1 receptor, type I
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
JUND jun D proto-oncogene
METRN meteorin, glial cell differentiation regulator
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
MSLN mesothelin
MTUS1 microtubule associated tumor suppressor 1
MXI1 MAX interactor 1, dimerization protein
MYO1D myosin ID
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NMRK1 nicotinamide riboside kinase 1
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE4B phosphodiesterase 4B, cAMP-specific
POU2AF1 POU class 2 associating factor 1
PPAP2B phosphatidic acid phosphatase type 2B
PPAP2C phosphatidic acid phosphatase type 2C
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PSAP prosaposin
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100P S100 calcium binding protein P
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SFRP4 secreted frizzled-related protein 4
SIK1 salt-inducible kinase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX13 sorting nexin 13
SQSTM1 sequestosome 1
STXBP1 syntaxin binding protein 1
SULF1 sulfatase 1
TACC2 transforming, acidic coiled-coil containing protein 2
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
UGDH UDP-glucose 6-dehydrogenase
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZHX2 zinc fingers and homeoboxes 2

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AMD1 adenosylmethionine decarboxylase 1
ANGPT1 angiopoietin 1
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BID BH3 interacting domain death agonist
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CALML3 calmodulin-like 3
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CEP55 centrosomal protein 55kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CLTB clathrin, light chain B
CSE1L CSE1 chromosome segregation 1-like (yeast)
CST3 cystatin C
CYB5A cytochrome b5 type A (microsomal)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EED embryonic ectoderm development
FAM111A family with sequence similarity 111, member A
FOLR1 folate receptor 1 (adult)
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLIPR1 GLI pathogenesis-related 1
GTSE1 G-2 and S-phase expressed 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFZ H2A histone family, member Z
HMGN3 high mobility group nucleosomal binding domain 3
HOPX HOP homeobox
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
IL13RA2 interleukin 13 receptor, alpha 2
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF20B kinesin family member 20B
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LMNB1 lamin B1
LOX lysyl oxidase
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
NAAA N-acylethanolamine acid amidase
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NPY neuropeptide Y
ORC6 origin recognition complex, subunit 6
PBK PDZ binding kinase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
PPAT phosphoribosyl pyrophosphate amidotransferase
PPL periplakin
PRC1 protein regulator of cytokinesis 1
RACGAP1 Rac GTPase activating protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RGS2 regulator of G-protein signaling 2
RRM1 ribonucleotide reductase M1
SCML1 sex comb on midleg-like 1 (Drosophila)
SHCBP1 SHC SH2-domain binding protein 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SORD sorbitol dehydrogenase
SPDL1 spindle apparatus coiled-coil protein 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TACC3 transforming, acidic coiled-coil containing protein 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UBE2C ubiquitin-conjugating enzyme E2C
VRK1 vaccinia related kinase 1
ZWILCH zwilch kinetochore protein
Funding