BRD-K67860401_GSK-3b Inhibitor VIII_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K67860401_GSK-3b Inhibitor VIII_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARG2 arginase 2
ARHGAP29 Rho GTPase activating protein 29
ARMCX2 armadillo repeat containing, X-linked 2
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
C10ORF10 chromosome 10 open reading frame 10
CD36 CD36 molecule (thrombospondin receptor)
CD9 CD9 molecule
CENPE centromere protein E, 312kDa
CFB complement factor B
CHMP5 charged multivesicular body protein 5
CRABP2 cellular retinoic acid binding protein 2
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYB5A cytochrome b5 type A (microsomal)
DCLK1 doublecortin-like kinase 1
DCN decorin
DUOX2 dual oxidase 2
FAM69A family with sequence similarity 69, member A
GMPR guanosine monophosphate reductase
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOPX HOP homeobox
HOXB2 homeobox B2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
KLK5 kallikrein-related peptidase 5
LPAR6 lysophosphatidic acid receptor 6
MAOA monoamine oxidase A
MBNL2 muscleblind-like splicing regulator 2
NEFH neurofilament, heavy polypeptide
OLFM4 olfactomedin 4
PCP4 Purkinje cell protein 4
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRL platelet-derived growth factor receptor-like
PKP2 plakophilin 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RET ret proto-oncogene
RFTN1 raftlin, lipid raft linker 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SNX7 sorting nexin 7
SST somatostatin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPD52L1 tumor protein D52-like 1
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
VSNL1 visinin-like 1
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AGR2 anterior gradient 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
ANXA6 annexin A6
BIK BCL2-interacting killer (apoptosis-inducing)
C6ORF62 chromosome 6 open reading frame 62
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP2 dual specificity phosphatase 2
EIF5 eukaryotic translation initiation factor 5
FOLR1 folate receptor 1 (adult)
HSPA1A heat shock 70kDa protein 1A
IL27RA interleukin 27 receptor, alpha
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
KIAA0100 KIAA0100
MAP2K6 mitogen-activated protein kinase kinase 6
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
METRN meteorin, glial cell differentiation regulator
NME4 NME/NM23 nucleoside diphosphate kinase 4
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PTX3 pentraxin 3, long
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPL37A ribosomal protein L37a
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNPO1 transportin 1
TOB1 transducer of ERBB2, 1
ZBTB20 zinc finger and BTB domain containing 20
Funding