BRD-K67868012_PI-103_LNCAP_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-K67868012_PI-103_LNCAP_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD2 abhydrolase domain containing 2
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
ARG1 arginase 1
ARID5B AT rich interactive domain 5B (MRF1-like)
CA12 carbonic anhydrase XII
CCL5 chemokine (C-C motif) ligand 5
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CUL4B cullin 4B
DUSP6 dual specificity phosphatase 6
EPN2 epsin 2
EPS8 epidermal growth factor receptor pathway substrate 8
FOXJ3 forkhead box J3
GAGE3 G antigen 3
GBP2 guanylate binding protein 2, interferon-inducible
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
HOPX HOP homeobox
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KDM3A lysine (K)-specific demethylase 3A
LYZ lysozyme
MT1M metallothionein 1M
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PF4 platelet factor 4
PLIN2 perilipin 2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RORA RAR-related orphan receptor A
RPA2 replication protein A2, 32kDa
S100A12 S100 calcium binding protein A12
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFRP1 secreted frizzled-related protein 1
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SOX4 SRY (sex determining region Y)-box 4
SPP1 secreted phosphoprotein 1
SYT1 synaptotagmin I
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPAN5 tetraspanin 5
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
APP amyloid beta (A4) precursor protein
ARL4C ADP-ribosylation factor-like 4C
ASS1 argininosuccinate synthase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BANF1 barrier to autointegration factor 1
BIRC3 baculoviral IAP repeat containing 3
C5ORF28 chromosome 5 open reading frame 28
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN1 calpain 1, (mu/I) large subunit
CCNB2 cyclin B2
CD24 CD24 molecule
CD47 CD47 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK4 cyclin-dependent kinase 4
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN7 claudin 7
CLIC5 chloride intracellular channel 5
CLU clusterin
CP ceruloplasmin (ferroxidase)
CPM carboxypeptidase M
CREB1 cAMP responsive element binding protein 1
CTSZ cathepsin Z
CYB5A cytochrome b5 type A (microsomal)
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4A3 eukaryotic translation initiation factor 4A3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FSTL1 follistatin-like 1
FZD5 frizzled class receptor 5
GPX1 glutathione peroxidase 1
GRB7 growth factor receptor-bound protein 7
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFX H2A histone family, member X
HBEGF heparin-binding EGF-like growth factor
HEXIM1 hexamethylene bis-acetamide inducible 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IL6R interleukin 6 receptor
JUNB jun B proto-oncogene
KAZN kazrin, periplakin interacting protein
KLK6 kallikrein-related peptidase 6
KRT19 keratin 19, type I
KRT4 keratin 4, type II
KRT7 keratin 7, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LOC100505650 uncharacterized LOC100505650
MALL mal, T-cell differentiation protein-like
MAT2A methionine adenosyltransferase II, alpha
MXRA5 matrix-remodelling associated 5
PAIP1 poly(A) binding protein interacting protein 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFN2 profilin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCGB2A1 secretoglobin, family 2A, member 1
SGCE sarcoglycan, epsilon
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SMCO4 single-pass membrane protein with coiled-coil domains 4
SOX11 SRY (sex determining region Y)-box 11
SPAG16 sperm associated antigen 16
SPATS2L spermatogenesis associated, serine-rich 2-like
SQLE squalene epoxidase
SST somatostatin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULF1 sulfatase 1
SYBU syntabulin (syntaxin-interacting)
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TUBB4B tubulin, beta 4B class IVb
UGCG UDP-glucose ceramide glucosyltransferase
WFDC2 WAP four-disulfide core domain 2
ZBED2 zinc finger, BED-type containing 2
Funding