| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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326 genes differentially expressed following the BRD-K67868012_PI-103_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 |
| ADIRF | adipogenesis regulatory factor |
| AES | amino-terminal enhancer of split |
| AGR2 | anterior gradient 2 |
| AHNAK2 | AHNAK nucleoprotein 2 |
| AKR1C1 | aldo-keto reductase family 1, member C1 |
| AKR1C2 | aldo-keto reductase family 1, member C2 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 |
| ATP9A | ATPase, class II, type 9A |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked |
| BASP1 | brain abundant, membrane attached signal protein 1 |
| BCL6 | B-cell CLL/lymphoma 6 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like |
| BTG1 | B-cell translocation gene 1, anti-proliferative |
| C10ORF10 | chromosome 10 open reading frame 10 |
| C1RL | complement component 1, r subcomponent-like |
| CALCOCO1 | calcium binding and coiled-coil domain 1 |
| CAMLG | calcium modulating ligand |
| CBLB | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
| CCNG2 | cyclin G2 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) |
| CDIPT | CDP-diacylglycerol--inositol 3-phosphatidyltransferase |
| CDK19 | cyclin-dependent kinase 19 |
| CFB | complement factor B |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) |
| CIRBP | cold inducible RNA binding protein |
| CPD | carboxypeptidase D |
| CREBL2 | cAMP responsive element binding protein-like 2 |
| CTSA | cathepsin A |
| CTSD | cathepsin D |
| CXCR4 | chemokine (C-X-C motif) receptor 4 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 |
| DCN | decorin |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 |
| DIAPH2 | diaphanous-related formin 2 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 |
| DSP | desmoplakin |
| EFNA1 | ephrin-A1 |
| EGFR | epidermal growth factor receptor |
| EPAS1 | endothelial PAS domain protein 1 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 |
| F2R | coagulation factor II (thrombin) receptor |
| FAM114A1 | family with sequence similarity 114, member A1 |
| FAM134B | family with sequence similarity 134, member B |
| FAXDC2 | fatty acid hydroxylase domain containing 2 |
| FKBP1B | FK506 binding protein 1B, 12.6 kDa |
| FOLR1 | folate receptor 1 (adult) |
| GAA | glucosidase, alpha; acid |
| GALC | galactosylceramidase |
| GLTSCR2 | glioma tumor suppressor candidate region gene 2 |
| GM2A | GM2 ganglioside activator |
| GPX3 | glutathione peroxidase 3 |
| GPX4 | glutathione peroxidase 4 |
| GRB10 | growth factor receptor-bound protein 10 |
| GRN | granulin |
| GSN | gelsolin |
| GSTZ1 | glutathione S-transferase zeta 1 |
| GUSBP3 | glucuronidase, beta pseudogene 3 |
| HBP1 | HMG-box transcription factor 1 |
| HIST1H2AC | histone cluster 1, H2ac |
| HIST1H2BD | histone cluster 1, H2bd |
| HIST3H2A | histone cluster 3, H2a |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 |
| HMGCL | 3-hydroxymethyl-3-methylglutaryl-CoA lyase |
| IDUA | iduronidase, alpha-L- |
| IFI6 | interferon, alpha-inducible protein 6 |
| IGBP1 | immunoglobulin (CD79A) binding protein 1 |
| IRS2 | insulin receptor substrate 2 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) |
| ITGB4 | integrin, beta 4 |
| ITGB5 | integrin, beta 5 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 |
| JUP | junction plakoglobin |
| KDM3A | lysine (K)-specific demethylase 3A |
| KDM5B | lysine (K)-specific demethylase 5B |
| KLHL24 | kelch-like family member 24 |
| LAMB3 | laminin, beta 3 |
| LAMC2 | laminin, gamma 2 |
| LAMP2 | lysosomal-associated membrane protein 2 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 |
| LEPR | leptin receptor |
| LGALS3 | lectin, galactoside-binding, soluble, 3 |
| LOX | lysyl oxidase |
| LTBP3 | latent transforming growth factor beta binding protein 3 |
| LXN | latexin |
| MAN2B1 | mannosidase, alpha, class 2B, member 1 |
| MET | MET proto-oncogene, receptor tyrosine kinase |
| MME | membrane metallo-endopeptidase |
| MSLN | mesothelin |
| MTSS1 | metastasis suppressor 1 |
| MUC1 | mucin 1, cell surface associated |
| MXRA7 | matrix-remodelling associated 7 |
| MYO6 | myosin VI |
| NBR1 | neighbor of BRCA1 gene 1 |
| NDRG1 | N-myc downstream regulated 1 |
| NGFRAP1 | nerve growth factor receptor (TNFRSF16) associated protein 1 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) |
| OPTN | optineurin |
| ORAI3 | ORAI calcium release-activated calcium modulator 3 |
| OSBPL10 | oxysterol binding protein-like 10 |
| OSMR | oncostatin M receptor |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) |
| PAM | peptidylglycine alpha-amidating monooxygenase |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) |
| PDZD2 | PDZ domain containing 2 |
| PIK3IP1 | phosphoinositide-3-kinase interacting protein 1 |
| PINK1 | PTEN induced putative kinase 1 |
| PLD3 | phospholipase D family, member 3 |
| PLXNB2 | plexin B2 |
| PNPLA2 | patatin-like phospholipase domain containing 2 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit |
| PPL | periplakin |
| PRAF2 | PRA1 domain family, member 2 |
| PSAP | prosaposin |
| PTK2B | protein tyrosine kinase 2 beta |
| PTPRE | protein tyrosine phosphatase, receptor type, E |
| RABAC1 | Rab acceptor 1 (prenylated) |
| RNF103 | ring finger protein 103 |
| RPS27L | ribosomal protein S27-like |
| RRAS | related RAS viral (r-ras) oncogene homolog |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) |
| SH3BGRL | SH3 domain binding glutamate-rich protein like |
| SLC38A2 | solute carrier family 38, member 2 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) |
| SOD2 | superoxide dismutase 2, mitochondrial |
| SOS2 | son of sevenless homolog 2 (Drosophila) |
| SOX4 | SRY (sex determining region Y)-box 4 |
| SPATA20 | spermatogenesis associated 20 |
| SPINT1 | serine peptidase inhibitor, Kunitz type 1 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 |
| SQSTM1 | sequestosome 1 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 |
| SULF1 | sulfatase 1 |
| SYT17 | synaptotagmin XVII |
| TCEAL4 | transcription elongation factor A (SII)-like 4 |
| TERT | telomerase reverse transcriptase |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
| TFPI2 | tissue factor pathway inhibitor 2 |
| TGM2 | transglutaminase 2 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 |
| TM4SF1 | transmembrane 4 L six family member 1 |
| TMEM59 | transmembrane protein 59 |
| TNS3 | tensin 3 |
| TP53I3 | tumor protein p53 inducible protein 3 |
| TPP1 | tripeptidyl peptidase I |
| TSC22D1 | TSC22 domain family, member 1 |
| TSC22D3 | TSC22 domain family, member 3 |
| TUBA1A | tubulin, alpha 1a |
| TUBB2B | tubulin, beta 2B class IIb |
| TXNIP | thioredoxin interacting protein |
| VAT1 | vesicle amine transport 1 |
| WDTC1 | WD and tetratricopeptide repeats 1 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 |
| YPEL5 | yippee-like 5 (Drosophila) |
| ZNF160 | zinc finger protein 160 |
| Symbol | Name |
|---|---|
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B |
| APP | amyloid beta (A4) precursor protein |
| AQP3 | aquaporin 3 (Gill blood group) |
| ASF1B | anti-silencing function 1B histone chaperone |
| ATAD2 | ATPase family, AAA domain containing 2 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide |
| AURKA | aurora kinase A |
| AURKB | aurora kinase B |
| BAG2 | BCL2-associated athanogene 2 |
| BIRC5 | baculoviral IAP repeat containing 5 |
| BRCA1 | breast cancer 1, early onset |
| C1QBP | complement component 1, q subcomponent binding protein |
| CACYBP | calcyclin binding protein |
| CCNA2 | cyclin A2 |
| CCNB1 | cyclin B1 |
| CCNE2 | cyclin E2 |
| CCNF | cyclin F |
| CCT2 | chaperonin containing TCP1, subunit 2 (beta) |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) |
| CDC20 | cell division cycle 20 |
| CDC25A | cell division cycle 25A |
| CDC42 | cell division cycle 42 |
| CDC45 | cell division cycle 45 |
| CDC6 | cell division cycle 6 |
| CDK1 | cyclin-dependent kinase 1 |
| CDK2 | cyclin-dependent kinase 2 |
| CENPN | centromere protein N |
| CENPU | centromere protein U |
| CEP55 | centrosomal protein 55kDa |
| COPS3 | COP9 signalosome subunit 3 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) |
| CTPS1 | CTP synthase 1 |
| DBF4 | DBF4 zinc finger |
| DDX10 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 |
| DDX39A | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A |
| DONSON | downstream neighbor of SON |
| DSCC1 | DNA replication and sister chromatid cohesion 1 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
| EDNRB | endothelin receptor type B |
| EFHD1 | EF-hand domain family, member D1 |
| EMG1 | EMG1 N1-specific pseudouridine methyltransferase |
| EXO1 | exonuclease 1 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit |
| FANCI | Fanconi anemia, complementation group I |
| FEN1 | flap structure-specific endonuclease 1 |
| FGFR3 | fibroblast growth factor receptor 3 |
| FOSL1 | FOS-like antigen 1 |
| FOXM1 | forkhead box M1 |
| GABBR2 | gamma-aminobutyric acid (GABA) B receptor, 2 |
| GAL | galanin/GMAP prepropeptide |
| GALNT3 | polypeptide N-acetylgalactosaminyltransferase 3 |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) |
| GLIPR1 | GLI pathogenesis-related 1 |
| GTSE1 | G-2 and S-phase expressed 1 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 |
| HAT1 | histone acetyltransferase 1 |
| HIST1H4C | histone cluster 1, H4c |
| HJURP | Holliday junction recognition protein |
| HMGB2 | high mobility group box 2 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B |
| ILF2 | interleukin enhancer binding factor 2 |
| KIF18B | kinesin family member 18B |
| KIF20A | kinesin family member 20A |
| LBR | lamin B receptor |
| LIG1 | ligase I, DNA, ATP-dependent |
| LMNB1 | lamin B1 |
| LTF | lactotransferrin |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) |
| MCAM | melanoma cell adhesion molecule |
| MCM10 | minichromosome maintenance complex component 10 |
| MCM4 | minichromosome maintenance complex component 4 |
| MCM5 | minichromosome maintenance complex component 5 |
| MCM6 | minichromosome maintenance complex component 6 |
| MCM7 | minichromosome maintenance complex component 7 |
| MELK | maternal embryonic leucine zipper kinase |
| MIS18A | MIS18 kinetochore protein A |
| MKI67 | marker of proliferation Ki-67 |
| MOCS2 | molybdenum cofactor synthesis 2 |
| MSX1 | msh homeobox 1 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 |
| NAV3 | neuron navigator 3 |
| NCAPG | non-SMC condensin I complex, subunit G |
| NCAPG2 | non-SMC condensin II complex, subunit G2 |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 |
| NOP56 | NOP56 ribonucleoprotein |
| NPY | neuropeptide Y |
| NRG1 | neuregulin 1 |
| NUDT15 | nudix (nucleoside diphosphate linked moiety X)-type motif 15 |
| NUSAP1 | nucleolar and spindle associated protein 1 |
| PARP2 | poly (ADP-ribose) polymerase 2 |
| PBK | PDZ binding kinase |
| PDSS1 | prenyl (decaprenyl) diphosphate synthase, subunit 1 |
| PFAS | phosphoribosylformylglycinamidine synthase |
| PHGDH | phosphoglycerate dehydrogenase |
| PLK1 | polo-like kinase 1 |
| PNP | purine nucleoside phosphorylase |
| POLA2 | polymerase (DNA directed), alpha 2, accessory subunit |
| POLR3G | polymerase (RNA) III (DNA directed) polypeptide G (32kD) |
| POLR3K | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa |
| POP5 | processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) |
| PRC1 | protein regulator of cytokinesis 1 |
| PSAT1 | phosphoserine aminotransferase 1 |
| PSMC3IP | PSMC3 interacting protein |
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) |
| RACGAP1 | Rac GTPase activating protein 1 |
| RAD51 | RAD51 recombinase |
| RAD54L | RAD54-like (S. cerevisiae) |
| RFC2 | replication factor C (activator 1) 2, 40kDa |
| RFC3 | replication factor C (activator 1) 3, 38kDa |
| RFC4 | replication factor C (activator 1) 4, 37kDa |
| RFC5 | replication factor C (activator 1) 5, 36.5kDa |
| RFWD3 | ring finger and WD repeat domain 3 |
| RPA2 | replication protein A2, 32kDa |
| RRM1 | ribonucleotide reductase M1 |
| RRM2 | ribonucleotide reductase M2 |
| SCGB1D2 | secretoglobin, family 1D, member 2 |
| SCGB2A1 | secretoglobin, family 2A, member 1 |
| SCGB2A2 | secretoglobin, family 2A, member 2 |
| SCML1 | sex comb on midleg-like 1 (Drosophila) |
| SDF2L1 | stromal cell-derived factor 2-like 1 |
| SERINC5 | serine incorporator 5 |
| SHCBP1 | SHC SH2-domain binding protein 1 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase |
| SLC25A46 | solute carrier family 25, member 46 |
| SMC1A | structural maintenance of chromosomes 1A |
| SNAP25 | synaptosomal-associated protein, 25kDa |
| SPC25 | SPC25, NDC80 kinetochore complex component |
| SPDL1 | spindle apparatus coiled-coil protein 1 |
| SRM | spermidine synthase |
| SRSF3 | serine/arginine-rich splicing factor 3 |
| SRSF7 | serine/arginine-rich splicing factor 7 |
| STOML2 | stomatin (EPB72)-like 2 |
| SUB1 | SUB1 homolog (S. cerevisiae) |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) |
| TACC3 | transforming, acidic coiled-coil containing protein 3 |
| TFAM | transcription factor A, mitochondrial |
| TFDP1 | transcription factor Dp-1 |
| TIMELESS | timeless circadian clock |
| TIPIN | TIMELESS interacting protein |
| TMEM194A | transmembrane protein 194A |
| TMEM97 | transmembrane protein 97 |
| TMPO | thymopoietin |
| TMX2 | thioredoxin-related transmembrane protein 2 |
| TPX2 | TPX2, microtubule-associated |
| TRA2B | transformer 2 beta homolog (Drosophila) |
| TRIP13 | thyroid hormone receptor interactor 13 |
| TYMS | thymidylate synthetase |
| UBE2S | ubiquitin-conjugating enzyme E2S |
| UBR7 | ubiquitin protein ligase E3 component n-recognin 7 (putative) |
| UCHL5 | ubiquitin carboxyl-terminal hydrolase L5 |
| UCK2 | uridine-cytidine kinase 2 |
| USP1 | ubiquitin specific peptidase 1 |
| VDAC3 | voltage-dependent anion channel 3 |
| VRK1 | vaccinia related kinase 1 |
| VSNL1 | visinin-like 1 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase |
| ZWILCH | zwilch kinetochore protein |
| ZWINT | ZW10 interacting kinetochore protein |
