BRD-K67870070_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K67870070_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AKR1C3 aldo-keto reductase family 1, member C3
AREG amphiregulin
CA12 carbonic anhydrase XII
CCK cholecystokinin
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CHMP4A charged multivesicular body protein 4A
CNN3 calponin 3, acidic
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSRP1 cysteine and glycine-rich protein 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPS8 epidermal growth factor receptor pathway substrate 8
FAM63A family with sequence similarity 63, member A
FCGBP Fc fragment of IgG binding protein
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GLIPR1 GLI pathogenesis-related 1
GPM6B glycoprotein M6B
GPX2 glutathione peroxidase 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
LEF1 lymphoid enhancer-binding factor 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LXN latexin
MATN2 matrilin 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
NID2 nidogen 2 (osteonidogen)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SOX9 SRY (sex determining region Y)-box 9
SPON1 spondin 1, extracellular matrix protein
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPBG trophoblast glycoprotein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAV3 vav 3 guanine nucleotide exchange factor
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AIM2 absent in melanoma 2
BCL6 B-cell CLL/lymphoma 6
CD36 CD36 molecule (thrombospondin receptor)
CNPY3 canopy FGF signaling regulator 3
CSTA cystatin A (stefin A)
CXCL13 chemokine (C-X-C motif) ligand 13
DAPK1 death-associated protein kinase 1
FABP4 fatty acid binding protein 4, adipocyte
FPGS folylpolyglutamate synthase
HLX H2.0-like homeobox
HMG20B high mobility group 20B
HOPX HOP homeobox
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KRT14 keratin 14, type I
KRT17 keratin 17, type I
MME membrane metallo-endopeptidase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
PEG10 paternally expressed 10
PLXNA1 plexin A1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
S100A6 S100 calcium binding protein A6
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
ZCCHC2 zinc finger, CCHC domain containing 2
Funding