BRD-K68007270_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-K68007270_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AIM1 absent in melanoma 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA4 annexin A4
ARHGAP29 Rho GTPase activating protein 29
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CAPG capping protein (actin filament), gelsolin-like
CCL20 chemokine (C-C motif) ligand 20
CD9 CD9 molecule
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP4A charged multivesicular body protein 4A
CLDN3 claudin 3
CLDN4 claudin 4
CLEC10A C-type lectin domain family 10, member A
CPM carboxypeptidase M
CRABP2 cellular retinoic acid binding protein 2
CTSZ cathepsin Z
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DTX4 deltex 4, E3 ubiquitin ligase
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GALC galactosylceramidase
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
HBE1 hemoglobin, epsilon 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
JCHAIN joining chain of multimeric IgA and IgM
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KRT15 keratin 15, type I
KRT18 keratin 18, type I
KRT23 keratin 23, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS2 lectin, galactoside-binding, soluble, 2
LGALS8 lectin, galactoside-binding, soluble, 8
LOC100505650 uncharacterized LOC100505650
LXN latexin
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MLPH melanophilin
MTSS1 metastasis suppressor 1
NEFH neurofilament, heavy polypeptide
NT5E 5'-nucleotidase, ecto (CD73)
P3H2 prolyl 3-hydroxylase 2
PDE4B phosphodiesterase 4B, cAMP-specific
PON3 paraoxonase 3
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAME preferentially expressed antigen in melanoma
QPCT glutaminyl-peptide cyclotransferase
RAI14 retinoic acid induced 14
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RTN1 reticulon 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SORBS2 sorbin and SH3 domain containing 2
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
VAMP8 vesicle-associated membrane protein 8
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ALDOA aldolase A, fructose-bisphosphate
ASPN asporin
ATF5 activating transcription factor 5
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CBR3 carbonyl reductase 3
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CETN3 centrin, EF-hand protein, 3
CTSC cathepsin C
CTTN cortactin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GOLGA8A golgin A8 family, member A
GPM6B glycoprotein M6B
IGF1R insulin-like growth factor 1 receptor
OLFML2B olfactomedin-like 2B
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PIH1D1 PIH1 domain containing 1
PLTP phospholipid transfer protein
PRDX4 peroxiredoxin 4
QKI QKI, KH domain containing, RNA binding
SLC35F2 solute carrier family 35, member F2
SRPX sushi-repeat containing protein, X-linked
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)