BRD-K68065987_MK-2206_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K68065987_MK-2206_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AHNAK2 AHNAK nucleoprotein 2
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
C14ORF1 chromosome 14 open reading frame 1
CD9 CD9 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CP ceruloplasmin (ferroxidase)
CTSK cathepsin K
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDR1 discoidin domain receptor tyrosine kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FABP7 fatty acid binding protein 7, brain
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GNPDA1 glucosamine-6-phosphate deaminase 1
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GRN granulin
HMGA2 high mobility group AT-hook 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
LAPTM4B lysosomal protein transmembrane 4 beta
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP1 matrix metallopeptidase 1
MSMO1 methylsterol monooxygenase 1
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
ORAI3 ORAI calcium release-activated calcium modulator 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMEL premelanosome protein
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PTGIS prostaglandin I2 (prostacyclin) synthase
RALGDS ral guanine nucleotide dissociation stimulator
S100A14 S100 calcium binding protein A14
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDCBP syndecan binding protein (syntenin)
SFRP1 secreted frizzled-related protein 1
SLC22A18 solute carrier family 22, member 18
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SOD2 superoxide dismutase 2, mitochondrial
SQLE squalene epoxidase
SQSTM1 sequestosome 1
TAGLN2 transgelin 2
TM4SF1 transmembrane 4 L six family member 1
TM7SF2 transmembrane 7 superfamily member 2
TPP1 tripeptidyl peptidase I
TRIB2 tribbles pseudokinase 2
TRIM29 tripartite motif containing 29
TSC22D1 TSC22 domain family, member 1
TYRP1 tyrosinase-related protein 1

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ASRGL1 asparaginase like 1
CA2 carbonic anhydrase II
CAMP cathelicidin antimicrobial peptide
CD200 CD200 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CXCL14 chemokine (C-X-C motif) ligand 14
CXCR4 chemokine (C-X-C motif) receptor 4
DACH1 dachshund family transcription factor 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
FAM46A family with sequence similarity 46, member A
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPC3 glypican 3
GPER1 G protein-coupled estrogen receptor 1
GSTM3 glutathione S-transferase mu 3 (brain)
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
ISG15 ISG15 ubiquitin-like modifier
JCHAIN joining chain of multimeric IgA and IgM
LAPTM5 lysosomal protein transmembrane 5
LIMCH1 LIM and calponin homology domains 1
LPL lipoprotein lipase
MEF2C myocyte enhancer factor 2C
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PROM1 prominin 1
RELN reelin
RPIA ribose 5-phosphate isomerase A
SDC2 syndecan 2
SDF2L1 stromal cell-derived factor 2-like 1
SNAP25 synaptosomal-associated protein, 25kDa
SRGN serglycin
WNT5A wingless-type MMTV integration site family, member 5A
Funding