BRD-K68065987_MK-2206_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K68065987_MK-2206_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
CCR1 chemokine (C-C motif) receptor 1
CD9 CD9 molecule
CLEC2B C-type lectin domain family 2, member B
COL11A1 collagen, type XI, alpha 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL3 chemokine (C-X-C motif) ligand 3
CYBB cytochrome b-245, beta polypeptide
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP6 dual specificity phosphatase 6
EFHD1 EF-hand domain family, member D1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERBB3 erb-b2 receptor tyrosine kinase 3
ERO1L ERO1-like (S. cerevisiae)
ESR1 estrogen receptor 1
FYB FYN binding protein
GATA3 GATA binding protein 3
GBP1 guanylate binding protein 1, interferon-inducible
GPNMB glycoprotein (transmembrane) nmb
HEPH hephaestin
HNMT histamine N-methyltransferase
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA2 heat shock 70kDa protein 2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
KCTD12 potassium channel tetramerization domain containing 12
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIMCH1 LIM and calponin homology domains 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAL mal, T-cell differentiation protein
MARCKS myristoylated alanine-rich protein kinase C substrate
MNAT1 MNAT CDK-activating kinase assembly factor 1
MTUS1 microtubule associated tumor suppressor 1
MUC1 mucin 1, cell surface associated
MYO6 myosin VI
NDRG1 N-myc downstream regulated 1
NEBL nebulette
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
P2RY13 purinergic receptor P2Y, G-protein coupled, 13
PPAP2B phosphatidic acid phosphatase type 2B
QDPR quinoid dihydropteridine reductase
QPCT glutaminyl-peptide cyclotransferase
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RPL39L ribosomal protein L39-like
S100A9 S100 calcium binding protein A9
SDC4 syndecan 4
SEPP1 selenoprotein P, plasma, 1
SERINC5 serine incorporator 5
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFEC transcription factor EC
UGDH UDP-glucose 6-dehydrogenase
XAF1 XIAP associated factor 1

decreased expression

Symbol Name
BID BH3 interacting domain death agonist
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CD24 CD24 molecule
DHRS2 dehydrogenase/reductase (SDR family) member 2
ELOVL2 ELOVL fatty acid elongase 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
IGLJ3 immunoglobulin lambda joining 3
LTBP1 latent transforming growth factor beta binding protein 1
MARCKSL1 MARCKS-like 1
NEB nebulin
PLK2 polo-like kinase 2
RRAD Ras-related associated with diabetes
SFRP1 secreted frizzled-related protein 1
TFPI2 tissue factor pathway inhibitor 2
THAP11 THAP domain containing 11
TMSB15A thymosin beta 15a
TUBB6 tubulin, beta 6 class V
WNT5A wingless-type MMTV integration site family, member 5A
Funding