BRD-K68065987_MK-2206_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-K68065987_MK-2206_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AHSG alpha-2-HS-glycoprotein
APOB apolipoprotein B
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BEX4 brain expressed, X-linked 4
C5AR1 complement component 5a receptor 1
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEMIP cell migration inducing protein, hyaluronan binding
CHN2 chimerin 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLEC11A C-type lectin domain family 11, member A
CLEC2B C-type lectin domain family 2, member B
COLEC11 collectin sub-family member 11
CREB1 cAMP responsive element binding protein 1
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
DCT dopachrome tautomerase
DPEP1 dipeptidase 1 (renal)
DUSP6 dual specificity phosphatase 6
E2F2 E2F transcription factor 2
EGR3 early growth response 3
EIF4A1 eukaryotic translation initiation factor 4A1
ERBB4 erb-b2 receptor tyrosine kinase 4
ETV1 ets variant 1
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP1 fatty acid binding protein 1, liver
FZD5 frizzled class receptor 5
GDF15 growth differentiation factor 15
GUSBP3 glucuronidase, beta pseudogene 3
HOXD1 homeobox D1
IGFBP1 insulin-like growth factor binding protein 1
IRS2 insulin receptor substrate 2
KLF4 Kruppel-like factor 4 (gut)
LDLR low density lipoprotein receptor
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MIR22HG MIR22 host gene
MTSS1 metastasis suppressor 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NT5E 5'-nucleotidase, ecto (CD73)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PERP PERP, TP53 apoptosis effector
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
QPCT glutaminyl-peptide cyclotransferase
RAB31 RAB31, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RNASE6 ribonuclease, RNase A family, k6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC38A1 solute carrier family 38, member 1
SPON1 spondin 1, extracellular matrix protein
SULF1 sulfatase 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
THBS2 thrombospondin 2
TOX3 TOX high mobility group box family member 3
TRIM2 tripartite motif containing 2
TXNIP thioredoxin interacting protein
TYRP1 tyrosinase-related protein 1
VNN1 vanin 1
XIST X inactive specific transcript (non-protein coding)
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOA aldolase A, fructose-bisphosphate
CAV2 caveolin 2
CD24 CD24 molecule
CDC42 cell division cycle 42
CDC6 cell division cycle 6
DDIT4 DNA-damage-inducible transcript 4
ERAP2 endoplasmic reticulum aminopeptidase 2
FBXO11 F-box protein 11
GBP1 guanylate binding protein 1, interferon-inducible
GINS2 GINS complex subunit 2 (Psf2 homolog)
KRT7 keratin 7, type II
LAMA3 laminin, alpha 3
LTF lactotransferrin
MYCBP MYC binding protein
NEFL neurofilament, light polypeptide
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PEX11A peroxisomal biogenesis factor 11 alpha
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFC2 replication factor C (activator 1) 2, 40kDa
SHCBP1 SHC SH2-domain binding protein 1
SLPI secretory leukocyte peptidase inhibitor
SNAP25 synaptosomal-associated protein, 25kDa
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TYMS thymidylate synthetase
YME1L1 YME1-like 1 ATPase
Funding