BRD-K68065987_MK-2206_MCF10A_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

123 genes differentially expressed following the BRD-K68065987_MK-2206_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
ALCAM activated leukocyte cell adhesion molecule
AMOTL2 angiomotin like 2
APOD apolipoprotein D
BCL2L1 BCL2-like 1
C1ORF106 chromosome 1 open reading frame 106
CAPG capping protein (actin filament), gelsolin-like
CASP10 caspase 10, apoptosis-related cysteine peptidase
CBR3 carbonyl reductase 3
CCDC109B coiled-coil domain containing 109B
CCL5 chemokine (C-C motif) ligand 5
CD9 CD9 molecule
CNN1 calponin 1, basic, smooth muscle
CREG1 cellular repressor of E1A-stimulated genes 1
CRIP1 cysteine-rich protein 1 (intestinal)
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPYSL2 dihydropyrimidinase-like 2
DUSP22 dual specificity phosphatase 22
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
FADS1 fatty acid desaturase 1
FADS3 fatty acid desaturase 3
FHL1 four and a half LIM domains 1
FLNA filamin A, alpha
FN1 fibronectin 1
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GSN gelsolin
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
IL32 interleukin 32
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB5 integrin, beta 5
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JCHAIN joining chain of multimeric IgA and IgM
KYNU kynureninase
LAMP2 lysosomal-associated membrane protein 2
LDLR low density lipoprotein receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LMOD1 leiomodin 1 (smooth muscle)
LRP10 low density lipoprotein receptor-related protein 10
LTBP2 latent transforming growth factor beta binding protein 2
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFGE8 milk fat globule-EGF factor 8 protein
MME membrane metallo-endopeptidase
MMP10 matrix metallopeptidase 10
MSMB microseminoprotein, beta-
MVP major vault protein
MYH11 myosin, heavy chain 11, smooth muscle
MYL9 myosin, light chain 9, regulatory
NT5E 5'-nucleotidase, ecto (CD73)
PLXNB2 plexin B2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PON3 paraoxonase 3
PPAP2B phosphatidic acid phosphatase type 2B
PPOX protoporphyrinogen oxidase
PROM1 prominin 1
PTK2B protein tyrosine kinase 2 beta
PTN pleiotrophin
RAI14 retinoic acid induced 14
RPS4Y1 ribosomal protein S4, Y-linked 1
SC5D sterol-C5-desaturase
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
STXBP2 syntaxin binding protein 2
TAGLN transgelin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TMSB15A thymosin beta 15a
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNIP1 TNFAIP3 interacting protein 1
TNNT1 troponin T type 1 (skeletal, slow)
TP53I3 tumor protein p53 inducible protein 3
TPM1 tropomyosin 1 (alpha)
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ASF1A anti-silencing function 1A histone chaperone
ATF5 activating transcription factor 5
BACE2 beta-site APP-cleaving enzyme 2
BLMH bleomycin hydrolase
CD44 CD44 molecule (Indian blood group)
CFI complement factor I
COL15A1 collagen, type XV, alpha 1
CXCL5 chemokine (C-X-C motif) ligand 5
DDIT4 DNA-damage-inducible transcript 4
DKC1 dyskeratosis congenita 1, dyskerin
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GGCT gamma-glutamylcyclotransferase
GNAS GNAS complex locus
GRIA2 glutamate receptor, ionotropic, AMPA 2
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IARS isoleucyl-tRNA synthetase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IKZF1 IKAROS family zinc finger 1 (Ikaros)
LAMP5 lysosomal-associated membrane protein family, member 5
LEF1 lymphoid enhancer-binding factor 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PNN pinin, desmosome associated protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
QDPR quinoid dihydropteridine reductase
RAD51C RAD51 paralog C
RBM25 RNA binding motif protein 25
RGS2 regulator of G-protein signaling 2
S100A8 S100 calcium binding protein A8
SCG2 secretogranin II
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNAP25 synaptosomal-associated protein, 25kDa
SORD sorbitol dehydrogenase
TESC tescalcin
Funding