BRD-K68174511_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

263 genes differentially expressed following the BRD-K68174511_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABR active BCR-related
ADGRE5 adhesion G protein-coupled receptor E5
AKAP12 A kinase (PRKA) anchor protein 12
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BCL2A1 BCL2-related protein A1
BCL3 B-cell CLL/lymphoma 3
BHLHE41 basic helix-loop-helix family, member e41
BIK BCL2-interacting killer (apoptosis-inducing)
BTG1 B-cell translocation gene 1, anti-proliferative
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLK2 CDC-like kinase 2
CLK4 CDC-like kinase 4
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL10A1 collagen, type X, alpha 1
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
CRIP1 cysteine-rich protein 1 (intestinal)
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CTSA cathepsin A
CTSB cathepsin B
CXCL8 chemokine (C-X-C motif) ligand 8
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DMTF1 cyclin D binding myb-like transcription factor 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EREG epiregulin
GADD45B growth arrest and DNA-damage-inducible, beta
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPR137B G protein-coupled receptor 137B
GPRC5A G protein-coupled receptor, class C, group 5, member A
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOOK2 hook microtubule-tethering protein 2
ICAM1 intercellular adhesion molecule 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INSIG1 insulin induced gene 1
KCNK1 potassium channel, two pore domain subfamily K, member 1
KCTD9 potassium channel tetramerization domain containing 9
KDM3A lysine (K)-specific demethylase 3A
KDM7A lysine (K)-specific demethylase 7A
KIAA0907 KIAA0907
KIAA1033 KIAA1033
KLF6 Kruppel-like factor 6
KYNU kynureninase
LIF leukemia inhibitory factor
LINC00342 long intergenic non-protein coding RNA 342
LOC100272216 uncharacterized LOC100272216
LY75 lymphocyte antigen 75
MGLL monoglyceride lipase
MLPH melanophilin
MT1HL1 metallothionein 1H-like 1
MTMR11 myotubularin related protein 11
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXI1 MAX interactor 1, dimerization protein
N4BP2L2 NEDD4 binding protein 2-like 2
NACA nascent polypeptide-associated complex alpha subunit
NBPF10 neuroblastoma breakpoint family, member 10
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIB nuclear factor I/B
NOTCH2NL notch 2 N-terminal like
NT5E 5'-nucleotidase, ecto (CD73)
OSMR oncostatin M receptor
PCDH9 protocadherin 9
PDE4DIP phosphodiesterase 4D interacting protein
PDE8A phosphodiesterase 8A
PILRB paired immunoglobin-like type 2 receptor beta
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLSCR3 phospholipid scramblase 3
PPOX protoporphyrinogen oxidase
PSPC1 paraspeckle component 1
PTMA prothymosin, alpha
RALGDS ral guanine nucleotide dissociation stimulator
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RSRC2 arginine/serine-rich coiled-coil 2
RSRP1 arginine/serine-rich protein 1
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SDC4 syndecan 4
SDCBP syndecan binding protein (syntenin)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SH3YL1 SH3 and SYLF domain containing 1
SLC16A6 solute carrier family 16, member 6
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A1 solute carrier family 38, member 1
SOD2 superoxide dismutase 2, mitochondrial
SULF1 sulfatase 1
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TP53 tumor protein p53
TREM1 triggering receptor expressed on myeloid cells 1
TRPS1 trichorhinophalangeal syndrome I
TSC22D1 TSC22 domain family, member 1
TXNL4B thioredoxin-like 4B
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UPP1 uridine phosphorylase 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCAN versican

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ADGRF5 adhesion G protein-coupled receptor F5
ADIRF adipogenesis regulatory factor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
APIP APAF1 interacting protein
ARG2 arginase 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASF1A anti-silencing function 1A histone chaperone
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B3GNT1
BAG2 BCL2-associated athanogene 2
BASP1 brain abundant, membrane attached signal protein 1
CALU calumenin
CBR1 carbonyl reductase 1
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CCND3 cyclin D3
CCNE2 cyclin E2
CD93 CD93 molecule
CDC25A cell division cycle 25A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK4 cyclin-dependent kinase 4
CERK ceramide kinase
CHN2 chimerin 2
CKB creatine kinase, brain
CLTB clathrin, light chain B
COX11 COX11 cytochrome c oxidase copper chaperone
CPE carboxypeptidase E
CSRP2 cysteine and glycine-rich protein 2
CTSZ cathepsin Z
CYB5A cytochrome b5 type A (microsomal)
DAD1 defender against cell death 1
DCXR dicarbonyl/L-xylulose reductase
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ECI2 enoyl-CoA delta isomerase 2
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELAVL1 ELAV like RNA binding protein 1
ENDOD1 endonuclease domain containing 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM198B family with sequence similarity 198, member B
FCGBP Fc fragment of IgG binding protein
FGFR3 fibroblast growth factor receptor 3
FGL2 fibrinogen-like 2
FILIP1L filamin A interacting protein 1-like
FKBP1B FK506 binding protein 1B, 12.6 kDa
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GCLC glutamate-cysteine ligase, catalytic subunit
GJA1 gap junction protein, alpha 1, 43kDa
HACD2 3-hydroxyacyl-CoA dehydratase 2
HACD3 3-hydroxyacyl-CoA dehydratase 3
HAT1 histone acetyltransferase 1
HDAC2 histone deacetylase 2
HHEX hematopoietically expressed homeobox
HIST1H4C histone cluster 1, H4c
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSPA1A heat shock 70kDa protein 1A
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
JUN jun proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KIAA0232 KIAA0232
KLHL23 kelch-like family member 23
KPNA3 karyopherin alpha 3 (importin alpha 4)
LAGE3 L antigen family, member 3
LAPTM4B lysosomal protein transmembrane 4 beta
LAPTM5 lysosomal protein transmembrane 5
LASP1 LIM and SH3 protein 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LPAR6 lysophosphatidic acid receptor 6
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MCUR1 mitochondrial calcium uniporter regulator 1
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MEGF9 multiple EGF-like-domains 9
MEIS2 Meis homeobox 2
MNDA myeloid cell nuclear differentiation antigen
MRPL17 mitochondrial ribosomal protein L17
MRPL34 mitochondrial ribosomal protein L34
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOL7 nucleolar protein 7, 27kDa
NR2F6 nuclear receptor subfamily 2, group F, member 6
NT5DC2 5'-nucleotidase domain containing 2
NXT1 nuclear transport factor 2-like export factor 1
OLFM4 olfactomedin 4
OLFML3 olfactomedin-like 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG10 paternally expressed 10
PFN2 profilin 2
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIR pirin (iron-binding nuclear protein)
PLTP phospholipid transfer protein
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSPH phosphoserine phosphatase
PTK2 protein tyrosine kinase 2
PTPRC protein tyrosine phosphatase, receptor type, C
RBP1 retinol binding protein 1, cellular
RBX1 ring-box 1, E3 ubiquitin protein ligase
RCN2 reticulocalbin 2, EF-hand calcium binding domain
REEP1 receptor accessory protein 1
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE6 ribonuclease, RNase A family, k6
RPA3 replication protein A3, 14kDa
RPS11 ribosomal protein S11
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
SDC2 syndecan 2
SFPQ splicing factor proline/glutamine-rich
SGK1 serum/glucocorticoid regulated kinase 1
SMCO4 single-pass membrane protein with coiled-coil domains 4
SPARCL1 SPARC-like 1 (hevin)
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae)
SRGN serglycin
SSR1 signal sequence receptor, alpha
TCF4 transcription factor 4
TM9SF2 transmembrane 9 superfamily member 2
TMEM14A transmembrane protein 14A
TMEM14B transmembrane protein 14B
TMEM230 transmembrane protein 230
TMEM50B transmembrane protein 50B
TPD52L1 tumor protein D52-like 1
TUBB tubulin, beta class I
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAMP3 vesicle-associated membrane protein 3
ZIC1 Zic family member 1
Funding