BRD-K68174511_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

275 genes differentially expressed following the BRD-K68174511_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKAP8L A kinase (PRKA) anchor protein 8-like
AKAP9 A kinase (PRKA) anchor protein 9
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
AMDHD2 amidohydrolase domain containing 2
ANKRD10 ankyrin repeat domain 10
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARFIP2 ADP-ribosylation factor interacting protein 2
ARHGAP32 Rho GTPase activating protein 32
ARID4B AT rich interactive domain 4B (RBP1-like)
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BECN1 beclin 1, autophagy related
BRD2 bromodomain containing 2
BRD8 bromodomain containing 8
BTN3A2 butyrophilin, subfamily 3, member A2
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CCDC28A coiled-coil domain containing 28A
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNL1 cyclin L1
CD44 CD44 molecule (Indian blood group)
CDK12 cyclin-dependent kinase 12
CDK19 cyclin-dependent kinase 19
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CHI3L2 chitinase 3-like 2
CLK4 CDC-like kinase 4
COL9A2 collagen, type IX, alpha 2
CPD carboxypeptidase D
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CUL7 cullin 7
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DARS aspartyl-tRNA synthetase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EIF1 eukaryotic translation initiation factor 1
ERBB2 erb-b2 receptor tyrosine kinase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM134C family with sequence similarity 134, member C
FASN fatty acid synthase
FNBP4 formin binding protein 4
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GAS1 growth arrest-specific 1
GBP2 guanylate binding protein 2, interferon-inducible
GCC2 GRIP and coiled-coil domain containing 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLGB1 golgin B1
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-B major histocompatibility complex, class I, B
HNMT histamine N-methyltransferase
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB5 integrin, beta 5
JUN jun proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIF20A kinesin family member 20A
KLF6 Kruppel-like factor 6
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KTN1 kinectin 1 (kinesin receptor)
KYNU kynureninase
LBP lipopolysaccharide binding protein
LDLR low density lipoprotein receptor
LETMD1 LETM1 domain containing 1
LOC100272216 uncharacterized LOC100272216
LOC399491
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LUM lumican
MAN2A1 mannosidase, alpha, class 2A, member 1
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MBTPS1 membrane-bound transcription factor peptidase, site 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MICALL1 MICAL-like 1
MMP7 matrix metallopeptidase 7
MTA1 metastasis associated 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO6 myosin VI
N4BP2L2 NEDD4 binding protein 2-like 2
NACA nascent polypeptide-associated complex alpha subunit
NAMPT nicotinamide phosphoribosyltransferase
NBPF10 neuroblastoma breakpoint family, member 10
NBR1 neighbor of BRCA1 gene 1
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NNT nicotinamide nucleotide transhydrogenase
NPC1 Niemann-Pick disease, type C1
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PABPN1 poly(A) binding protein, nuclear 1
PARP6 poly (ADP-ribose) polymerase family, member 6
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4DIP phosphodiesterase 4D interacting protein
PDIA5 protein disulfide isomerase family A, member 5
PDZK1IP1 PDZK1 interacting protein 1
PER1 period circadian clock 1
PILRB paired immunoglobin-like type 2 receptor beta
PIP prolactin-induced protein
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PNKP polynucleotide kinase 3'-phosphatase
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
QPCT glutaminyl-peptide cyclotransferase
RAP1GAP RAP1 GTPase activating protein
RBM39 RNA binding motif protein 39
RBM5 RNA binding motif protein 5
RND3 Rho family GTPase 3
RSRC2 arginine/serine-rich coiled-coil 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCYL3 SCY1-like 3 (S. cerevisiae)
SEPP1 selenoprotein P, plasma, 1
SH3YL1 SH3 and SYLF domain containing 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC35F2 solute carrier family 35, member F2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPATA20 spermatogenesis associated 20
SPG11 spastic paraplegia 11 (autosomal recessive)
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRRM2 serine/arginine repetitive matrix 2
SRSF6 serine/arginine-rich splicing factor 6
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STON1 stonin 1
STX1A syntaxin 1A (brain)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TARBP1 TAR (HIV-1) RNA binding protein 1
TGM2 transglutaminase 2
TNC tenascin C
TOM1L1 target of myb1 (chicken)-like 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TSC22D3 TSC22 domain family, member 3
TTC3 tetratricopeptide repeat domain 3
TTC37 tetratricopeptide repeat domain 37
TXNL4B thioredoxin-like 4B
USP34 ubiquitin specific peptidase 34
VIM vimentin
WDR19 WD repeat domain 19
ZC3H11A zinc finger CCCH-type containing 11A
ZFP36 ZFP36 ring finger protein
ZNF451 zinc finger protein 451
ZNF692 zinc finger protein 692

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACOT7 acyl-CoA thioesterase 7
ADD3 adducin 3 (gamma)
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADIRF adipogenesis regulatory factor
APIP APAF1 interacting protein
ARL3 ADP-ribosylation factor-like 3
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASF1A anti-silencing function 1A histone chaperone
ATF5 activating transcription factor 5
B3GNT1
BAG5 BCL2-associated athanogene 5
C1ORF116 chromosome 1 open reading frame 116
C6ORF62 chromosome 6 open reading frame 62
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CBFB core-binding factor, beta subunit
CCND3 cyclin D3
CCNE2 cyclin E2
CD24 CD24 molecule
CD58 CD58 molecule
CDC25A cell division cycle 25A
CHIC2 cysteine-rich hydrophobic domain 2
CKLF chemokine-like factor
CLIC5 chloride intracellular channel 5
CPE carboxypeptidase E
CXCL14 chemokine (C-X-C motif) ligand 14
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCK deoxycytidine kinase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLC1 DLC1 Rho GTPase activating protein
DUSP7 dual specificity phosphatase 7
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGL2 fibrinogen-like 2
FOXF1 forkhead box F1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GCH1 GTP cyclohydrolase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLRX2 glutaredoxin 2
GLRX5 glutaredoxin 5
GREM1 gremlin 1, DAN family BMP antagonist
GRWD1 glutamate-rich WD repeat containing 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HPRT1 hypoxanthine phosphoribosyltransferase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
ISG15 ISG15 ubiquitin-like modifier
KLHL7 kelch-like family member 7
LEPROTL1 leptin receptor overlapping transcript-like 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MALL mal, T-cell differentiation protein-like
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MAT2A methionine adenosyltransferase II, alpha
MAX MYC associated factor X
MFAP4 microfibrillar-associated protein 4
MME membrane metallo-endopeptidase
MYH10 myosin, heavy chain 10, non-muscle
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NR2F6 nuclear receptor subfamily 2, group F, member 6
OLFM4 olfactomedin 4
PCP4 Purkinje cell protein 4
PEX11A peroxisomal biogenesis factor 11 alpha
PHACTR2 phosphatase and actin regulator 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIR pirin (iron-binding nuclear protein)
PNP purine nucleoside phosphorylase
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPIF peptidylprolyl isomerase F
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTPRE protein tyrosine phosphatase, receptor type, E
QKI QKI, KH domain containing, RNA binding
RCAN1 regulator of calcineurin 1
RPS11 ribosomal protein S11
RTN1 reticulon 1
SDC2 syndecan 2
SDF2L1 stromal cell-derived factor 2-like 1
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEPHS1 selenophosphate synthetase 1
SEPW1 selenoprotein W, 1
SFN stratifin
SFPQ splicing factor proline/glutamine-rich
SIVA1 SIVA1, apoptosis-inducing factor
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLIRP SRA stem-loop interacting RNA binding protein
TBPL1 TBP-like 1
TCF4 transcription factor 4
TFDP1 transcription factor Dp-1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THAP11 THAP domain containing 11
THBS1 thrombospondin 1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIPIN TIMELESS interacting protein
TMEM50B transmembrane protein 50B
TMX1 thioredoxin-related transmembrane protein 1
TSPAN7 tetraspanin 7
VDAC3 voltage-dependent anion channel 3
VRK1 vaccinia related kinase 1
WFS1 Wolfram syndrome 1 (wolframin)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
Funding