BRD-K68174511_torin-2_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

355 genes differentially expressed following the BRD-K68174511_torin-2_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AMDHD2 amidohydrolase domain containing 2
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
AOX1 aldehyde oxidase 1
ATF4 activating transcription factor 4
AVL9 AVL9 homolog (S. cerevisiase)
BAG1 BCL2-associated athanogene
BHLHE41 basic helix-loop-helix family, member e41
C16ORF45 chromosome 16 open reading frame 45
C6ORF48 chromosome 6 open reading frame 48
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CAMLG calcium modulating ligand
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CCNL1 cyclin L1
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CGA glycoprotein hormones, alpha polypeptide
CHGB chromogranin B
CIRBP cold inducible RNA binding protein
COL9A3 collagen, type IX, alpha 3
CREBL2 cAMP responsive element binding protein-like 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTSK cathepsin K
DCLK1 doublecortin-like kinase 1
DDIT3 DNA-damage-inducible transcript 3
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DOCK9 dedicator of cytokinesis 9
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EIF4B eukaryotic translation initiation factor 4B
EPAS1 endothelial PAS domain protein 1
FAM149B1 family with sequence similarity 149, member B1
FAM50A family with sequence similarity 50, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FBXW4 F-box and WD repeat domain containing 4
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO4 forkhead box O4
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLS glutaminase
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLGA8H golgin A8 family, member H
GPATCH8 G patch domain containing 8
GPX4 glutathione peroxidase 4
GSDMB gasdermin B
GSN gelsolin
GTF2IRD1 GTF2I repeat domain containing 1
HBP1 HMG-box transcription factor 1
HDAC5 histone deacetylase 5
HEBP1 heme binding protein 1
HIST1H2AC histone cluster 1, H2ac
HMG20B high mobility group 20B
HOOK2 hook microtubule-tethering protein 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGBP1 immunoglobulin (CD79A) binding protein 1
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIF13B kinesin family member 13B
KIF5C kinesin family member 5C
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KYNU kynureninase
LAMA3 laminin, alpha 3
LDLR low density lipoprotein receptor
LEPR leptin receptor
LETMD1 LETM1 domain containing 1
LINC00342 long intergenic non-protein coding RNA 342
LOC399491
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K5 mitogen-activated protein kinase kinase 5
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MTMR11 myotubularin related protein 11
MXI1 MAX interactor 1, dimerization protein
MZF1 myeloid zinc finger 1
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NMRK1 nicotinamide riboside kinase 1
NPC1 Niemann-Pick disease, type C1
NRN1 neuritin 1
OFD1 oral-facial-digital syndrome 1
OPTN optineurin
OSBPL1A oxysterol binding protein-like 1A
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PARP6 poly (ADP-ribose) polymerase family, member 6
PGLS 6-phosphogluconolactonase
PHYH phytanoyl-CoA 2-hydroxylase
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PILRB paired immunoglobin-like type 2 receptor beta
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLA2G16 phospholipase A2, group XVI
PLCB4 phospholipase C, beta 4
PNRC1 proline-rich nuclear receptor coactivator 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PTGES prostaglandin E synthase
QPCT glutaminyl-peptide cyclotransferase
RAB9A RAB9A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS10 regulator of G-protein signaling 10
RIOK3 RIO kinase 3
RPL28 ribosomal protein L28
RPL36 ribosomal protein L36
RPL38 ribosomal protein L38
RPL4 ribosomal protein L4
RUFY3 RUN and FYVE domain containing 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SLC16A6 solute carrier family 16, member 6
SNAP25 synaptosomal-associated protein, 25kDa
SPATA20 spermatogenesis associated 20
SPATA7 spermatogenesis associated 7
SPINK1 serine peptidase inhibitor, Kazal type 1
SRPX sushi-repeat containing protein, X-linked
SRSF7 serine/arginine-rich splicing factor 7
STAT5B signal transducer and activator of transcription 5B
STMN2 stathmin 2
STX1A syntaxin 1A (brain)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMC5 transmembrane channel-like 5
TMEM135 transmembrane protein 135
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
VWA8 von Willebrand factor A domain containing 8
WDR45 WD repeat domain 45
WISP2 WNT1 inducible signaling pathway protein 2
YPEL5 yippee-like 5 (Drosophila)
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AQP3 aquaporin 3 (Gill blood group)
ASF1A anti-silencing function 1A histone chaperone
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
AURKA aurora kinase A
AURKB aurora kinase B
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA2 carbonic anhydrase II
CALML3 calmodulin-like 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CCND2 cyclin D2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
CIT citron rho-interacting serine/threonine kinase
CKS1B CDC28 protein kinase regulatory subunit 1B
CNN3 calponin 3, acidic
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CXCL14 chemokine (C-X-C motif) ligand 14
DBF4 DBF4 zinc finger
DEPDC1 DEP domain containing 1
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
E2F8 E2F transcription factor 8
ECT2 epithelial cell transforming 2
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMP2 epithelial membrane protein 2
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GCLM glutamate-cysteine ligase, modifier subunit
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GINS4 GINS complex subunit 4 (Sld5 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HBB hemoglobin, beta
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HSPA1A heat shock 70kDa protein 1A
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT13 keratin 13, type I
KRT4 keratin 4, type II
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MEIS2 Meis homeobox 2
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC1 NDC1 transmembrane nucleoporin
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
ORC6 origin recognition complex, subunit 6
PBK PDZ binding kinase
PGAM1 phosphoglycerate mutase 1 (brain)
PHGDH phosphoglycerate dehydrogenase
PKP1 plakophilin 1
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PSAT1 phosphoserine aminotransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAD51C RAD51 paralog C
RAD54B RAD54 homolog B (S. cerevisiae)
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SGK1 serum/glucocorticoid regulated kinase 1
SHCBP1 SHC SH2-domain binding protein 1
SIVA1 SIVA1, apoptosis-inducing factor
SKA1 spindle and kinetochore associated complex subunit 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC2 structural maintenance of chromosomes 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPC25 SPC25, NDC80 kinetochore complex component
SPRR1A small proline-rich protein 1A
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
STIL SCL/TAL1 interrupting locus
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
THBS1 thrombospondin 1
TK1 thymidine kinase 1, soluble
TMEM97 transmembrane protein 97
TMPO thymopoietin
TMX1 thioredoxin-related transmembrane protein 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TTK TTK protein kinase
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
WDHD1 WD repeat and HMG-box DNA binding protein 1
WT1 Wilms tumor 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein
Funding