BRD-K68174511_torin-2_HCC515_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

282 genes differentially expressed following the BRD-K68174511_torin-2_HCC515_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AHNAK2 AHNAK nucleoprotein 2
AKAP13 A kinase (PRKA) anchor protein 13
AKAP9 A kinase (PRKA) anchor protein 9
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
AMDHD2 amidohydrolase domain containing 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD12 ankyrin repeat domain 12
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BRD2 bromodomain containing 2
C6ORF48 chromosome 6 open reading frame 48
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC93 coiled-coil domain containing 93
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CCNL2 cyclin L2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK12 cyclin-dependent kinase 12
CFP complement factor properdin
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CLK4 CDC-like kinase 4
CLU clusterin
CNR1 cannabinoid receptor 1 (brain)
COL10A1 collagen, type X, alpha 1
COL2A1 collagen, type II, alpha 1
CPVL carboxypeptidase, vitellogenic-like
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTSA cathepsin A
CTSB cathepsin B
CXCR4 chemokine (C-X-C motif) receptor 4
CYB5R1 cytochrome b5 reductase 1
DALRD3 DALR anticodon binding domain containing 3
DDIT3 DNA-damage-inducible transcript 3
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF4B eukaryotic translation initiation factor 4B
ENOSF1 enolase superfamily member 1
EVI2A ecotropic viral integration site 2A
FOXO4 forkhead box O4
GAA glucosidase, alpha; acid
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP2 guanylate binding protein 2, interferon-inducible
GLS glutaminase
GNPDA1 glucosamine-6-phosphate deaminase 1
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPNMB glycoprotein (transmembrane) nmb
GSDMB gasdermin B
HBP1 HMG-box transcription factor 1
HDAC5 histone deacetylase 5
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ICAM1 intercellular adhesion molecule 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IRS2 insulin receptor substrate 2
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIAA0430 KIAA0430
KIAA1033 KIAA1033
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KYNU kynureninase
LACTB2 lactamase, beta 2
LAMA3 laminin, alpha 3
LETMD1 LETM1 domain containing 1
LOC399491
LONP2 lon peptidase 2, peroxisomal
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP2K5 mitogen-activated protein kinase kinase 5
MCOLN1 mucolipin 1
MEF2C myocyte enhancer factor 2C
MTMR11 myotubularin related protein 11
MXI1 MAX interactor 1, dimerization protein
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
NRN1 neuritin 1
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
OSBPL1A oxysterol binding protein-like 1A
OSER1 oxidative stress responsive serine-rich 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP6 poly (ADP-ribose) polymerase family, member 6
PCBP2 poly(rC) binding protein 2
PDIA5 protein disulfide isomerase family A, member 5
PHF1 PHD finger protein 1
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PILRB paired immunoglobin-like type 2 receptor beta
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTBP2 polypyrimidine tract binding protein 2
RAB9A RAB9A, member RAS oncogene family
RAD9A RAD9 homolog A (S. pombe)
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RAP1GAP RAP1 GTPase activating protein
RB1CC1 RB1-inducible coiled-coil 1
RBKS ribokinase
RBM5 RNA binding motif protein 5
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RPL31 ribosomal protein L31
RRAGC Ras-related GTP binding C
RRAGD Ras-related GTP binding D
RSRP1 arginine/serine-rich protein 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC35E2B solute carrier family 35, member E2B
SLC38A1 solute carrier family 38, member 1
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPAG9 sperm associated antigen 9
SPATA20 spermatogenesis associated 20
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
SQSTM1 sequestosome 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRSF7 serine/arginine-rich splicing factor 7
STX1A syntaxin 1A (brain)
STYXL1 serine/threonine/tyrosine interacting-like 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBC1D15 TBC1 domain family, member 15
TEX10 testis expressed 10
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM260 transmembrane protein 260
TPP1 tripeptidyl peptidase I
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSC22D3 TSC22 domain family, member 3
TSPAN4 tetraspanin 4
TYMP thymidine phosphorylase
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBE2B ubiquitin-conjugating enzyme E2B
UGDH UDP-glucose 6-dehydrogenase
VDAC1 voltage-dependent anion channel 1
VNN1 vanin 1
WSB1 WD repeat and SOCS box containing 1
ZCCHC14 zinc finger, CCHC domain containing 14
ZDHHC6 zinc finger, DHHC-type containing 6
ZNF292 zinc finger protein 292
ZNF91 zinc finger protein 91
ZSWIM8 zinc finger, SWIM-type containing 8

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACKR3 atypical chemokine receptor 3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL4C ADP-ribosylation factor-like 4C
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCND2 cyclin D2
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC25A cell division cycle 25A
CDK2 cyclin-dependent kinase 2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CKB creatine kinase, brain
COL15A1 collagen, type XV, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CPE carboxypeptidase E
CPOX coproporphyrinogen oxidase
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTSZ cathepsin Z
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
EHF ets homologous factor
EIF4E eukaryotic translation initiation factor 4E
EIF5A eukaryotic translation initiation factor 5A
ELAVL1 ELAV like RNA binding protein 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPHA2 EPH receptor A2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
FSTL1 follistatin-like 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GSTP1 glutathione S-transferase pi 1
H2AFX H2A histone family, member X
HDGFRP3 hepatoma-derived growth factor, related protein 3
HES1 hes family bHLH transcription factor 1
HMBS hydroxymethylbilane synthase
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HPRT1 hypoxanthine phosphoribosyltransferase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI16 interferon, gamma-inducible protein 16
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
KAZN kazrin, periplakin interacting protein
KCTD12 potassium channel tetramerization domain containing 12
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT13 keratin 13, type I
KRT15 keratin 15, type I
LBH limb bud and heart development
LDHB lactate dehydrogenase B
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMO2 LIM domain only 2 (rhombotin-like 1)
MBNL1 muscleblind-like splicing regulator 1
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MEIS2 Meis homeobox 2
MFAP4 microfibrillar-associated protein 4
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP10 matrix metallopeptidase 10
MPZL2 myelin protein zero-like 2
MSH6 mutS homolog 6
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
MYH10 myosin, heavy chain 10, non-muscle
NDN necdin, melanoma antigen (MAGE) family member
NLRP2 NLR family, pyrin domain containing 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F2 nuclear receptor subfamily 2, group F, member 2
OAT ornithine aminotransferase
OLFM4 olfactomedin 4
PCNA proliferating cell nuclear antigen
PIGR polymeric immunoglobulin receptor
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRSS23 protease, serine, 23
PSPH phosphoserine phosphatase
RCAN2 regulator of calcineurin 2
RFC3 replication factor C (activator 1) 3, 38kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCGB2A1 secretoglobin, family 2A, member 1
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SOSTDC1 sclerostin domain containing 1
SOX17 SRY (sex determining region Y)-box 17
TACSTD2 tumor-associated calcium signal transducer 2
TFDP1 transcription factor Dp-1
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
THBS1 thrombospondin 1
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TRIM14 tripartite motif containing 14
TSPYL5 TSPY-like 5
TUBG1 tubulin, gamma 1
WFDC2 WAP four-disulfide core domain 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF652 zinc finger protein 652
Funding