BRD-K68174511_torin-2_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

260 genes differentially expressed following the BRD-K68174511_torin-2_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMDHD2 amidohydrolase domain containing 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD12 ankyrin repeat domain 12
ATF4 activating transcription factor 4
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
C6ORF48 chromosome 6 open reading frame 48
CAPN3 calpain 3, (p94)
CCDC28A coiled-coil domain containing 28A
CCDC93 coiled-coil domain containing 93
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD24 CD24 molecule
CD9 CD9 molecule
CDK19 cyclin-dependent kinase 19
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHKA choline kinase alpha
CLK4 CDC-like kinase 4
CLTA clathrin, light chain A
COL9A3 collagen, type IX, alpha 3
CRIP1 cysteine-rich protein 1 (intestinal)
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTSA cathepsin A
CYB5R1 cytochrome b5 reductase 1
DALRD3 DALR anticodon binding domain containing 3
DCLK1 doublecortin-like kinase 1
DDIT3 DNA-damage-inducible transcript 3
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EIF4B eukaryotic translation initiation factor 4B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F13A1 coagulation factor XIII, A1 polypeptide
FABP3 fatty acid binding protein 3, muscle and heart
FAM134A family with sequence similarity 134, member A
FAM50A family with sequence similarity 50, member A
FOXG1 forkhead box G1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FXYD2 FXYD domain containing ion transport regulator 2
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GLS glutaminase
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNPDA1 glucosamine-6-phosphate deaminase 1
GNS glucosamine (N-acetyl)-6-sulfatase
GOLGA8A golgin A8 family, member A
GOLGA8H golgin A8 family, member H
GOLGB1 golgin B1
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
GSN gelsolin
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
HBP1 HMG-box transcription factor 1
HDAC5 histone deacetylase 5
HEXA hexosaminidase A (alpha polypeptide)
HIST1H2BG histone cluster 1, H2bg
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
HS1BP3 HCLS1 binding protein 3
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IFRD1 interferon-related developmental regulator 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM3A lysine (K)-specific demethylase 3A
KIAA1033 KIAA1033
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LOC399491
LRMP lymphoid-restricted membrane protein
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCOLN1 mucolipin 1
MEF2C myocyte enhancer factor 2C
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MTMR11 myotubularin related protein 11
MXI1 MAX interactor 1, dimerization protein
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
NT5C2 5'-nucleotidase, cytosolic II
NUPR1 nuclear protein, transcriptional regulator, 1
OFD1 oral-facial-digital syndrome 1
OSBPL1A oxysterol binding protein-like 1A
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP6 poly (ADP-ribose) polymerase family, member 6
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PILRB paired immunoglobin-like type 2 receptor beta
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PNMA2 paraneoplastic Ma antigen 2
PNRC1 proline-rich nuclear receptor coactivator 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRKCSH protein kinase C substrate 80K-H
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSPC1 paraspeckle component 1
RAB29 RAB29, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RB1CC1 RB1-inducible coiled-coil 1
RBKS ribokinase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RRAGC Ras-related GTP binding C
RRAGD Ras-related GTP binding D
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFRP4 secreted frizzled-related protein 4
SKAP2 src kinase associated phosphoprotein 2
SLC16A6 solute carrier family 16, member 6
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC35E3 solute carrier family 35, member E3
SLC38A1 solute carrier family 38, member 1
SLC38A6 solute carrier family 38, member 6
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SPAG9 sperm associated antigen 9
SQSTM1 sequestosome 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRSF7 serine/arginine-rich splicing factor 7
SSH3 slingshot protein phosphatase 3
STX1A syntaxin 1A (brain)
STX7 syntaxin 7
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYT1 synaptotagmin I
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBC1D15 TBC1 domain family, member 15
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTA T-cell leukemia translocation altered
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TSPAN4 tetraspanin 4
TTC17 tetratricopeptide repeat domain 17
TXNIP thioredoxin interacting protein
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UPP1 uridine phosphorylase 1
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
VNN1 vanin 1
YPEL5 yippee-like 5 (Drosophila)
ZDHHC11 zinc finger, DHHC-type containing 11
ZFP36 ZFP36 ring finger protein
ZNF277 zinc finger protein 277
ZNF292 zinc finger protein 292
ZSWIM8 zinc finger, SWIM-type containing 8

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACKR3 atypical chemokine receptor 3
ACLY ATP citrate lyase
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL4C ADP-ribosylation factor-like 4C
ATAD2 ATPase family, AAA domain containing 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCHE butyrylcholinesterase
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCND2 cyclin D2
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CNN3 calponin 3, acidic
COL15A1 collagen, type XV, alpha 1
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL4A5 collagen, type IV, alpha 5
CSTA cystatin A (stefin A)
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
EIF4E eukaryotic translation initiation factor 4E
EIF5A eukaryotic translation initiation factor 5A
ELAVL1 ELAV like RNA binding protein 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FABP1 fatty acid binding protein 1, liver
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FJX1 four jointed box 1 (Drosophila)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
HAT1 histone acetyltransferase 1
HDGFRP3 hepatoma-derived growth factor, related protein 3
HES1 hes family bHLH transcription factor 1
HMBS hydroxymethylbilane synthase
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HPRT1 hypoxanthine phosphoribosyltransferase 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITM2A integral membrane protein 2A
LEF1 lymphoid enhancer-binding factor 1
LMNB1 lamin B1
LMO2 LIM domain only 2 (rhombotin-like 1)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MPZL2 myelin protein zero-like 2
MRPL19 mitochondrial ribosomal protein L19
MYCBP MYC binding protein
MYH10 myosin, heavy chain 10, non-muscle
NELL2 NEL-like 2 (chicken)
NLRP2 NLR family, pyrin domain containing 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F2 nuclear receptor subfamily 2, group F, member 2
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCNA proliferating cell nuclear antigen
PHGDH phosphoglycerate dehydrogenase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POSTN periostin, osteoblast specific factor
PSPH phosphoserine phosphatase
RFC3 replication factor C (activator 1) 3, 38kDa
S100A7 S100 calcium binding protein A7
SELL selectin L
SERTAD2 SERTA domain containing 2
SIK1 salt-inducible kinase 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SORD sorbitol dehydrogenase
SPTSSA serine palmitoyltransferase, small subunit A
STK10 serine/threonine kinase 10
SUB1 SUB1 homolog (S. cerevisiae)
TFDP1 transcription factor Dp-1
TFRC transferrin receptor
THBS1 thrombospondin 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMELESS timeless circadian clock
TMEM97 transmembrane protein 97
TNC tenascin C
TRIM14 tripartite motif containing 14
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBG1 tubulin, gamma 1
Funding