BRD-K68174511_torin-2_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

231 genes differentially expressed following the BRD-K68174511_torin-2_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
AGTPBP1 ATP/GTP binding protein 1
AMDHD2 amidohydrolase domain containing 2
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANGPTL2 angiopoietin-like 2
ANKRD36B ankyrin repeat domain 36B
ARG1 arginase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BPI bactericidal/permeability-increasing protein
C6ORF48 chromosome 6 open reading frame 48
CAPRIN2 caprin family member 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIRBP cold inducible RNA binding protein
CLDN10 claudin 10
CP ceruloplasmin (ferroxidase)
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTGF connective tissue growth factor
CYFIP2 cytoplasmic FMR1 interacting protein 2
DEFA4 defensin, alpha 4, corticostatin
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPP4 dipeptidyl-peptidase 4
ECHDC2 enoyl CoA hydratase domain containing 2
EIF1 eukaryotic translation initiation factor 1
ELANE elastase, neutrophil expressed
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAM193B family with sequence similarity 193, member B
FNBP1 formin binding protein 1
FST follistatin
G0S2 G0/G1 switch 2
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GADD45B growth arrest and DNA-damage-inducible, beta
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HAL histidine ammonia-lyase
HDAC6 histone deacetylase 6
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HIST1H2BG histone cluster 1, H2bg
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HTRA2 HtrA serine peptidase 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP1 insulin-like growth factor binding protein 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL17RB interleukin 17 receptor B
IL18 interleukin 18
IRS1 insulin receptor substrate 1
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KIAA0907 KIAA0907
KIAA1033 KIAA1033
KIF5C kinesin family member 5C
KLHL21 kelch-like family member 21
LCN2 lipocalin 2
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LOC399491
LRRC16A leucine rich repeat containing 16A
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MFSD10 major facilitator superfamily domain containing 10
MT1F metallothionein 1F
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NINJ2 ninjurin 2
NKTR natural killer cell triggering receptor
NOTCH2NL notch 2 N-terminal like
NR1D2 nuclear receptor subfamily 1, group D, member 2
NSUN5P2 NOP2/Sun domain family, member 5 pseudogene 2
OPTN optineurin
OSBPL3 oxysterol binding protein-like 3
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PARP6 poly (ADP-ribose) polymerase family, member 6
PARP8 poly (ADP-ribose) polymerase family, member 8
PAXBP1 PAX3 and PAX7 binding protein 1
PEG3 paternally expressed 3
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PILRB paired immunoglobin-like type 2 receptor beta
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLIN2 perilipin 2
PLSCR3 phospholipid scramblase 3
PSD3 pleckstrin and Sec7 domain containing 3
RAB40B RAB40B, member RAS oncogene family
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RALGDS ral guanine nucleotide dissociation stimulator
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBM5 RNA binding motif protein 5
RIOK3 RIO kinase 3
RNASET2 ribonuclease T2
RRAGD Ras-related GTP binding D
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SEPP1 selenoprotein P, plasma, 1
SF1 splicing factor 1
SLAMF7 SLAM family member 7
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SRSF6 serine/arginine-rich splicing factor 6
SRSF7 serine/arginine-rich splicing factor 7
SST somatostatin
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STX1A syntaxin 1A (brain)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYNJ2 synaptojanin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBC1D15 TBC1 domain family, member 15
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGM2 transglutaminase 2
TMSB15A thymosin beta 15a
TRA2A transformer 2 alpha homolog (Drosophila)
TRAK2 trafficking protein, kinesin binding 2
TSPAN5 tetraspanin 5
TSTA3 tissue specific transplantation antigen P35B
VAT1 vesicle amine transport 1
VNN1 vanin 1
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF292 zinc finger protein 292
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
APP amyloid beta (A4) precursor protein
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BST2 bone marrow stromal cell antigen 2
CAPZB capping protein (actin filament) muscle Z-line, beta
CD93 CD93 molecule
COL5A1 collagen, type V, alpha 1
CTSC cathepsin C
CTSZ cathepsin Z
CXCL10 chemokine (C-X-C motif) ligand 10
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDIT4 DNA-damage-inducible transcript 4
DESI2 desumoylating isopeptidase 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELAVL1 ELAV like RNA binding protein 1
ENO1 enolase 1, (alpha)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP4 fatty acid binding protein 4, adipocyte
FBN2 fibrillin 2
FEN1 flap structure-specific endonuclease 1
FKBP14 FK506 binding protein 14, 22 kDa
GALE UDP-galactose-4-epimerase
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPX2 glutathione peroxidase 2
H2AFZ H2A histone family, member Z
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KRT13 keratin 13, type I
KRT7 keratin 7, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
MLEC malectin
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
MX1 MX dynamin-like GTPase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NDNF neuron-derived neurotrophic factor
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NLGN4X neuroligin 4, X-linked
OLFM4 olfactomedin 4
OPN3 opsin 3
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PBX1 pre-B-cell leukemia homeobox 1
PCNA proliferating cell nuclear antigen
PDGFD platelet derived growth factor D
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PGAM1 phosphoglycerate mutase 1 (brain)
PGD phosphogluconate dehydrogenase
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PITX1 paired-like homeodomain 1
PLAC8 placenta-specific 8
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PSPH phosphoserine phosphatase
RGS1 regulator of G-protein signaling 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRM2 ribonucleotide reductase M2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMCO4 single-pass membrane protein with coiled-coil domains 4
SPRR3 small proline-rich protein 3
SPTSSA serine palmitoyltransferase, small subunit A
SQLE squalene epoxidase
SRP9 signal recognition particle 9kDa
TARS threonyl-tRNA synthetase
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TMX1 thioredoxin-related transmembrane protein 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNC1 troponin C type 1 (slow)
TP53 tumor protein p53
TRIM16 tripartite motif containing 16
TYMS thymidylate synthetase
WARS tryptophanyl-tRNA synthetase
Funding