BRD-K68174511_torin-2_MCF10A_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

256 genes differentially expressed following the BRD-K68174511_torin-2_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD4 abhydrolase domain containing 4
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOD apolipoprotein D
AREG amphiregulin
ARMCX1 armadillo repeat containing, X-linked 1
ATF4 activating transcription factor 4
ATP9A ATPase, class II, type 9A
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CALCOCO1 calcium binding and coiled-coil domain 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD9 CD9 molecule
CDK19 cyclin-dependent kinase 19
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFD complement factor D (adipsin)
CFLAR CASP8 and FADD-like apoptosis regulator
CHRDL1 chordin-like 1
COBL cordon-bleu WH2 repeat protein
COL10A1 collagen, type X, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CRYAB crystallin, alpha B
CST1 cystatin SN
CXCL14 chemokine (C-X-C motif) ligand 14
CXCR4 chemokine (C-X-C motif) receptor 4
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DOCK9 dedicator of cytokinesis 9
DST dystonin
DUSP3 dual specificity phosphatase 3
EAPP E2F-associated phosphoprotein
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EFHC1 EF-hand domain (C-terminal) containing 1
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EPS8L2 EPS8-like 2
ERBB2 erb-b2 receptor tyrosine kinase 2
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
F13A1 coagulation factor XIII, A1 polypeptide
FAM50A family with sequence similarity 50, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FBXW4 F-box and WD repeat domain containing 4
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FMO2 flavin containing monooxygenase 2 (non-functional)
FOXO3 forkhead box O3
GAA glucosidase, alpha; acid
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GATA3 GATA binding protein 3
GATAD1 GATA zinc finger domain containing 1
GBP2 guanylate binding protein 2, interferon-inducible
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GOLGA8A golgin A8 family, member A
GPNMB glycoprotein (transmembrane) nmb
GPX4 glutathione peroxidase 4
GRN granulin
GSN gelsolin
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HDAC5 histone deacetylase 5
HIST1H2AC histone cluster 1, H2ac
HLA-E major histocompatibility complex, class I, E
HOOK2 hook microtubule-tethering protein 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDS iduronate 2-sulfatase
IER5 immediate early response 5
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IRF9 interferon regulatory factor 9
IRS2 insulin receptor substrate 2
ITGA10 integrin, alpha 10
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB4 integrin, beta 4
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
KYNU kynureninase
LGALS3 lectin, galactoside-binding, soluble, 3
LTBP1 latent transforming growth factor beta binding protein 1
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MYH11 myosin, heavy chain 11, smooth muscle
NAV2 neuron navigator 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NMRK1 nicotinamide riboside kinase 1
NOTCH3 notch 3
NPDC1 neural proliferation, differentiation and control, 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PER1 period circadian clock 1
PGLS 6-phosphogluconolactonase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLA2G16 phospholipase A2, group XVI
PNRC1 proline-rich nuclear receptor coactivator 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRELP proline/arginine-rich end leucine-rich repeat protein
PRTN3 proteinase 3
PTN pleiotrophin
PXDC1 PX domain containing 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBKS ribokinase
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RRAGC Ras-related GTP binding C
RSRP1 arginine/serine-rich protein 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC35E2B solute carrier family 35, member E2B
SLC38A1 solute carrier family 38, member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGM2 transglutaminase 2
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)
ZBTB16 zinc finger and BTB domain containing 16
ZNF277 zinc finger protein 277
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADI1 acireductone dioxygenase 1
ADRB2 adrenoceptor beta 2, surface
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CCL20 chemokine (C-C motif) ligand 20
CCNA2 cyclin A2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DLC1 DLC1 Rho GTPase activating protein
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF4E eukaryotic translation initiation factor 4E
ELAVL1 ELAV like RNA binding protein 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HOXA5 homeobox A5
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA14 heat shock 70kDa protein 14
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFRD2 interferon-related developmental regulator 2
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL1RN interleukin 1 receptor antagonist
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
KAZN kazrin, periplakin interacting protein
KIAA0020 KIAA0020
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LMNB1 lamin B1
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAK16 MAK16 homolog (S. cerevisiae)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MGST2 microsomal glutathione S-transferase 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAV3 neuron navigator 3
NOLC1 nucleolar and coiled-body phosphoprotein 1
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP1 poly (ADP-ribose) polymerase 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PGAM1 phosphoglycerate mutase 1 (brain)
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PLAT plasminogen activator, tissue
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPIF peptidylprolyl isomerase F
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PSAT1 phosphoserine aminotransferase 1
QDPR quinoid dihydropteridine reductase
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1D2 secretoglobin, family 1D, member 2
SDF2L1 stromal cell-derived factor 2-like 1
SEH1L SEH1-like (S. cerevisiae)
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNAP25 synaptosomal-associated protein, 25kDa
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SORD sorbitol dehydrogenase
SRSF7 serine/arginine-rich splicing factor 7
TFAM transcription factor A, mitochondrial
TFRC transferrin receptor
TMEM97 transmembrane protein 97
TMX1 thioredoxin-related transmembrane protein 1
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TUBB6 tubulin, beta 6 class V
TYMS thymidylate synthetase
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
VSNL1 visinin-like 1
WT1 Wilms tumor 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZWINT ZW10 interacting kinetochore protein
Funding