BRD-K68174511_torin-2_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

64 genes differentially expressed following the BRD-K68174511_torin-2_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGTR1 angiotensin II receptor, type 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AQP3 aquaporin 3 (Gill blood group)
BTG1 B-cell translocation gene 1, anti-proliferative
C1QB complement component 1, q subcomponent, B chain
C6ORF48 chromosome 6 open reading frame 48
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CHN1 chimerin 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC3B C-type lectin domain family 3, member B
CP ceruloplasmin (ferroxidase)
CRISP3 cysteine-rich secretory protein 3
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
EFNA1 ephrin-A1
EIF4B eukaryotic translation initiation factor 4B
EPAS1 endothelial PAS domain protein 1
ERBB3 erb-b2 receptor tyrosine kinase 3
FGF13 fibroblast growth factor 13
FOXO4 forkhead box O4
FZD6 frizzled class receptor 6
GATA2 GATA binding protein 2
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
H2AFV H2A histone family, member V
HECA headcase homolog (Drosophila)
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
KDM5B lysine (K)-specific demethylase 5B
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MARCKS myristoylated alanine-rich protein kinase C substrate
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NUPR1 nuclear protein, transcriptional regulator, 1
PDE2A phosphodiesterase 2A, cGMP-stimulated
PSPH phosphoserine phosphatase
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAB1 stabilin 1
TACSTD2 tumor-associated calcium signal transducer 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN7 tetraspanin 7

decreased expression

Symbol Name
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CTPS1 CTP synthase 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
EREG epiregulin
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
GAS1 growth arrest-specific 1
HMGA2 high mobility group AT-hook 2
KIAA0226L KIAA0226-like
LAT2 linker for activation of T cells family, member 2
MELK maternal embryonic leucine zipper kinase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NEFH neurofilament, heavy polypeptide
RAD51C RAD51 paralog C
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
Funding