BRD-K68174511_torin-2_MCF7_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

183 genes differentially expressed following the BRD-K68174511_torin-2_MCF7_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACSL1 acyl-CoA synthetase long-chain family member 1
ADGRG6 adhesion G protein-coupled receptor G6
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BRD8 bromodomain containing 8
BSPRY B-box and SPRY domain containing
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CCL20 chemokine (C-C motif) ligand 20
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPU centromere protein U
COL9A3 collagen, type IX, alpha 3
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CYFIP2 cytoplasmic FMR1 interacting protein 2
DEPTOR DEP domain containing MTOR-interacting protein
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
EPCAM epithelial cell adhesion molecule
EPHB2 EPH receptor B2
EPS8 epidermal growth factor receptor pathway substrate 8
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FKBP10 FK506 binding protein 10, 65 kDa
FN1 fibronectin 1
G6PD glucose-6-phosphate dehydrogenase
GADD45B growth arrest and DNA-damage-inducible, beta
GPC4 glypican 4
GRAMD1C GRAM domain containing 1C
GRB14 growth factor receptor-bound protein 14
GUSB glucuronidase, beta
GUSBP11 glucuronidase, beta pseudogene 11
HAL histidine ammonia-lyase
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOOK2 hook microtubule-tethering protein 2
IGF1R insulin-like growth factor 1 receptor
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP5 insulin-like growth factor binding protein 5
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITM2C integral membrane protein 2C
KDM3A lysine (K)-specific demethylase 3A
KIF20A kinesin family member 20A
KRT1 keratin 1, type II
KYNU kynureninase
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
MYB v-myb avian myeloblastosis viral oncogene homolog
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOTCH2NL notch 2 N-terminal like
NRIP1 nuclear receptor interacting protein 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX3 pre-B-cell leukemia homeobox 3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE1A phosphodiesterase 1A, calmodulin-dependent
PILRB paired immunoglobin-like type 2 receptor beta
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PRDX4 peroxiredoxin 4
PSPC1 paraspeckle component 1
PXDN peroxidasin
SCYL3 SCY1-like 3 (S. cerevisiae)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRPX sushi-repeat containing protein, X-linked
STX1A syntaxin 1A (brain)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D31 TBC1 domain family, member 31
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TLR4 toll-like receptor 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VCAN versican
XIST X inactive specific transcript (non-protein coding)
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
ACLY ATP citrate lyase
ADIRF adipogenesis regulatory factor
ADRB2 adrenoceptor beta 2, surface
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANXA1 annexin A1
ARL4C ADP-ribosylation factor-like 4C
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BEX4 brain expressed, X-linked 4
BIK BCL2-interacting killer (apoptosis-inducing)
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND1 cyclin D1
CDC25A cell division cycle 25A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
COL3A1 collagen, type III, alpha 1
COTL1 coactosin-like F-actin binding protein 1
CPB1 carboxypeptidase B1 (tissue)
CTBP1 C-terminal binding protein 1
CTSZ cathepsin Z
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DPYSL2 dihydropyrimidinase-like 2
DYNLT3 dynein, light chain, Tctex-type 3
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EFHD2 EF-hand domain family, member D2
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FASTKD5 FAST kinase domains 5
FGFBP1 fibroblast growth factor binding protein 1
G0S2 G0/G1 switch 2
GATA2 GATA binding protein 2
GNAS GNAS complex locus
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
GSTA1 glutathione S-transferase alpha 1
HBB hemoglobin, beta
HEG1 heart development protein with EGF-like domains 1
IL32 interleukin 32
ITPKB inositol-trisphosphate 3-kinase B
JAG1 jagged 1
KIAA0232 KIAA0232
KRT13 keratin 13, type I
KRT17 keratin 17, type I
LAP3 leucine aminopeptidase 3
LMO2 LIM domain only 2 (rhombotin-like 1)
LPAR2 lysophosphatidic acid receptor 2
LTF lactotransferrin
LYN LYN proto-oncogene, Src family tyrosine kinase
LYZ lysozyme
MAT2A methionine adenosyltransferase II, alpha
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MICALL1 MICAL-like 1
MSN moesin
MSX1 msh homeobox 1
NELL2 NEL-like 2 (chicken)
NNMT nicotinamide N-methyltransferase
ODC1 ornithine decarboxylase 1
OLFML2A olfactomedin-like 2A
PFKP phosphofructokinase, platelet
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PNO1 partner of NOB1 homolog (S. cerevisiae)
PODXL podocalyxin-like
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RBP1 retinol binding protein 1, cellular
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SACS sacsin molecular chaperone
SCGB2A1 secretoglobin, family 2A, member 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SNAI2 snail family zinc finger 2
SNAP25 synaptosomal-associated protein, 25kDa
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
TAGLN transgelin
UPK1B uroplakin 1B
Funding