BRD-K68174511_torin-2_SKBR3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

207 genes differentially expressed following the BRD-K68174511_torin-2_SKBR3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACKR3 atypical chemokine receptor 3
AKAP9 A kinase (PRKA) anchor protein 9
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANKRD36B ankyrin repeat domain 36B
APOD apolipoprotein D
ATP9A ATPase, class II, type 9A
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLMN calmin (calponin-like, transmembrane)
COBL cordon-bleu WH2 repeat protein
CST1 cystatin SN
CST3 cystatin C
CTSL cathepsin L
CYTH1 cytohesin 1
DEFB1 defensin, beta 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3L eukaryotic translation initiation factor 3, subunit L
EIF4B eukaryotic translation initiation factor 4B
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPAS1 endothelial PAS domain protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM134A family with sequence similarity 134, member A
FAM134B family with sequence similarity 134, member B
FOLR1 folate receptor 1 (adult)
FOXO3 forkhead box O3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GCC2 GRIP and coiled-coil domain containing 2
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRB10 growth factor receptor-bound protein 10
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMGA1 high mobility group AT-hook 1
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IQGAP1 IQ motif containing GTPase activating protein 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KAT6B K(lysine) acetyltransferase 6B
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLHL24 kelch-like family member 24
KYNU kynureninase
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
LOC100272216 uncharacterized LOC100272216
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MEIS1 Meis homeobox 1
MGLL monoglyceride lipase
MGST3 microsomal glutathione S-transferase 3
MLPH melanophilin
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MTSS1 metastasis suppressor 1
MVP major vault protein
MYLIP myosin regulatory light chain interacting protein
NBPF10 neuroblastoma breakpoint family, member 10
NET1 neuroepithelial cell transforming 1
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NR4A2 nuclear receptor subfamily 4, group A, member 2
NSG1 neuron specific gene family member 1
PDLIM5 PDZ and LIM domain 5
PERP PERP, TP53 apoptosis effector
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLIN2 perilipin 2
POLR1D polymerase (RNA) I polypeptide D, 16kDa
RAP1GAP RAP1 GTPase activating protein
RGS10 regulator of G-protein signaling 10
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
RPL36 ribosomal protein L36
RPS27L ribosomal protein S27-like
RSRP1 arginine/serine-rich protein 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SECISBP2L SECIS binding protein 2-like
SEPP1 selenoprotein P, plasma, 1
SH3BP4 SH3-domain binding protein 4
SLC38A2 solute carrier family 38, member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPDEF SAM pointed domain containing ETS transcription factor
STXBP2 syntaxin binding protein 2
SYNJ2 synaptojanin 2
TBL1X transducin (beta)-like 1X-linked
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TRIM2 tripartite motif containing 2
TSC22D1 TSC22 domain family, member 1
UBXN4 UBX domain protein 4
UBXN7 UBX domain protein 7
WASL Wiskott-Aldrich syndrome-like
WDR45 WD repeat domain 45
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
AK1 adenylate kinase 1
ARPC5L actin related protein 2/3 complex, subunit 5-like
ATAD2 ATPase family, AAA domain containing 2
BAD BCL2-associated agonist of cell death
BIRC5 baculoviral IAP repeat containing 5
C1ORF116 chromosome 1 open reading frame 116
CCNA2 cyclin A2
CCND2 cyclin D2
CCNE2 cyclin E2
CCR2 chemokine (C-C motif) receptor 2
CD24 CD24 molecule
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCK deoxycytidine kinase
DNA2 DNA replication helicase/nuclease 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELAVL1 ELAV like RNA binding protein 1
ENO1 enolase 1, (alpha)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPC3 glypican 3
HBS1L HBS1-like translational GTPase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSPA1A heat shock 70kDa protein 1A
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IGHD immunoglobulin heavy constant delta
IRAK1 interleukin-1 receptor-associated kinase 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JCHAIN joining chain of multimeric IgA and IgM
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAGE3 L antigen family, member 3
LBR lamin B receptor
LMNB1 lamin B1
LMO4 LIM domain only 4
LTB lymphotoxin beta (TNF superfamily, member 3)
LUM lumican
MELK maternal embryonic leucine zipper kinase
MFAP4 microfibrillar-associated protein 4
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NEB nebulin
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCCB propionyl CoA carboxylase, beta polypeptide
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRKCA protein kinase C, alpha
PRPS1 phosphoribosyl pyrophosphate synthetase 1
RAD51C RAD51 paralog C
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
S100A2 S100 calcium binding protein A2
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMC4 structural maintenance of chromosomes 4
SPC25 SPC25, NDC80 kinetochore complex component
SPINK1 serine peptidase inhibitor, Kazal type 1
SPP1 secreted phosphoprotein 1
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SULF1 sulfatase 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TMEM97 transmembrane protein 97
TRA2B transformer 2 beta homolog (Drosophila)
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
UBE2S ubiquitin-conjugating enzyme E2S
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
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