| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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342 genes differentially expressed following the BRD-K68174511_torin-2_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 |
| ABHD4 | abhydrolase domain containing 4 |
| ADAM10 | ADAM metallopeptidase domain 10 |
| AGR2 | anterior gradient 2 |
| ANKRA2 | ankyrin repeat, family A (RFXANK-like), 2 |
| ARFIP2 | ADP-ribosylation factor interacting protein 2 |
| ARHGAP32 | Rho GTPase activating protein 32 |
| ATP6V1G1 | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 |
| BACE2 | beta-site APP-cleaving enzyme 2 |
| BCAS1 | breast carcinoma amplified sequence 1 |
| BRD2 | bromodomain containing 2 |
| BTG1 | B-cell translocation gene 1, anti-proliferative |
| C6ORF48 | chromosome 6 open reading frame 48 |
| CA12 | carbonic anhydrase XII |
| CAPN3 | calpain 3, (p94) |
| CCNB1IP1 | cyclin B1 interacting protein 1, E3 ubiquitin protein ligase |
| CD44 | CD44 molecule (Indian blood group) |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) |
| CDK12 | cyclin-dependent kinase 12 |
| CDK19 | cyclin-dependent kinase 19 |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) |
| CEMIP | cell migration inducing protein, hyaluronan binding |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) |
| CLDN4 | claudin 4 |
| CLMN | calmin (calponin-like, transmembrane) |
| COBL | cordon-bleu WH2 repeat protein |
| CST1 | cystatin SN |
| CTH | cystathionine gamma-lyase |
| CTSL | cathepsin L |
| CYB5R1 | cytochrome b5 reductase 1 |
| DDIT3 | DNA-damage-inducible transcript 3 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 |
| DUSP1 | dual specificity phosphatase 1 |
| DUSP14 | dual specificity phosphatase 14 |
| DUSP4 | dual specificity phosphatase 4 |
| EFNA1 | ephrin-A1 |
| EFTUD1 | elongation factor Tu GTP binding domain containing 1 |
| EGF | epidermal growth factor |
| EIF4B | eukaryotic translation initiation factor 4B |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
| EXPH5 | exophilin 5 |
| FAM102A | family with sequence similarity 102, member A |
| FGF13 | fibroblast growth factor 13 |
| FKBP14 | FK506 binding protein 14, 22 kDa |
| FMOD | fibromodulin |
| FXR1 | fragile X mental retardation, autosomal homolog 1 |
| GALNT6 | polypeptide N-acetylgalactosaminyltransferase 6 |
| GALNT7 | polypeptide N-acetylgalactosaminyltransferase 7 |
| GCC2 | GRIP and coiled-coil domain containing 2 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type |
| GDF15 | growth differentiation factor 15 |
| GLRX | glutaredoxin (thioltransferase) |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 |
| GPR137B | G protein-coupled receptor 137B |
| GPR37 | G protein-coupled receptor 37 (endothelin receptor type B-like) |
| GRAMD1C | GRAM domain containing 1C |
| GRB7 | growth factor receptor-bound protein 7 |
| GSAP | gamma-secretase activating protein |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 |
| GUSBP3 | glucuronidase, beta pseudogene 3 |
| H1F0 | H1 histone family, member 0 |
| HBP1 | HMG-box transcription factor 1 |
| HES1 | hes family bHLH transcription factor 1 |
| HIST1H2AC | histone cluster 1, H2ac |
| HIST1H2BD | histone cluster 1, H2bd |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) |
| HOOK2 | hook microtubule-tethering protein 2 |
| HSD11B2 | hydroxysteroid (11-beta) dehydrogenase 2 |
| HSPA2 | heat shock 70kDa protein 2 |
| ICA1 | islet cell autoantigen 1, 69kDa |
| IFRD1 | interferon-related developmental regulator 1 |
| IGBP1 | immunoglobulin (CD79A) binding protein 1 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 |
| IRS2 | insulin receptor substrate 2 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 |
| KDM3A | lysine (K)-specific demethylase 3A |
| KIAA0907 | KIAA0907 |
| KIAA1033 | KIAA1033 |
| KLF6 | Kruppel-like factor 6 |
| KMO | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) |
| KYNU | kynureninase |
| LAMA3 | laminin, alpha 3 |
| LAMP2 | lysosomal-associated membrane protein 2 |
| LCN2 | lipocalin 2 |
| LDLR | low density lipoprotein receptor |
| LLGL2 | lethal giant larvae homolog 2 (Drosophila) |
| LOC100272216 | uncharacterized LOC100272216 |
| LRRC16A | leucine rich repeat containing 16A |
| LXN | latexin |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
| MAP7 | microtubule-associated protein 7 |
| MGLL | monoglyceride lipase |
| MLPH | melanophilin |
| MTUS1 | microtubule associated tumor suppressor 1 |
| MVP | major vault protein |
| MYO6 | myosin VI |
| N4BP2L2 | NEDD4 binding protein 2-like 2 |
| NDRG1 | N-myc downstream regulated 1 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 |
| NPAS2 | neuronal PAS domain protein 2 |
| NUCB2 | nucleobindin 2 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 |
| OPN3 | opsin 3 |
| PCDH9 | protocadherin 9 |
| PDCD6 | programmed cell death 6 |
| PDE8A | phosphodiesterase 8A |
| PDLIM5 | PDZ and LIM domain 5 |
| PDZK1IP1 | PDZK1 interacting protein 1 |
| PIK3IP1 | phosphoinositide-3-kinase interacting protein 1 |
| PILRB | paired immunoglobin-like type 2 receptor beta |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit |
| POLR1D | polymerase (RNA) I polypeptide D, 16kDa |
| PRKCH | protein kinase C, eta |
| PRKCQ | protein kinase C, theta |
| PRPF3 | pre-mRNA processing factor 3 |
| PRSS8 | protease, serine, 8 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 |
| QPCT | glutaminyl-peptide cyclotransferase |
| RAP1GAP | RAP1 GTPase activating protein |
| RIOK3 | RIO kinase 3 |
| RPL36 | ribosomal protein L36 |
| RSRP1 | arginine/serine-rich protein 1 |
| S100P | S100 calcium binding protein P |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 |
| SCGB2A1 | secretoglobin, family 2A, member 1 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit |
| SCYL3 | SCY1-like 3 (S. cerevisiae) |
| SECISBP2L | SECIS binding protein 2-like |
| SFRP4 | secreted frizzled-related protein 4 |
| SH3YL1 | SH3 and SYLF domain containing 1 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 |
| SLC16A4 | solute carrier family 16, member 4 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 |
| SLC22A18 | solute carrier family 22, member 18 |
| SLC44A4 | solute carrier family 44, member 4 |
| SPDEF | SAM pointed domain containing ETS transcription factor |
| SPTLC2 | serine palmitoyltransferase, long chain base subunit 2 |
| SQSTM1 | sequestosome 1 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 |
| SYT17 | synaptotagmin XVII |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
| TMC5 | transmembrane channel-like 5 |
| TMEM63A | transmembrane protein 63A |
| TMEM87A | transmembrane protein 87A |
| TOM1L1 | target of myb1 (chicken)-like 1 |
| TOX3 | TOX high mobility group box family member 3 |
| TPST2 | tyrosylprotein sulfotransferase 2 |
| TRIM2 | tripartite motif containing 2 |
| TRPM4 | transient receptor potential cation channel, subfamily M, member 4 |
| TSC22D3 | TSC22 domain family, member 3 |
| TSG101 | tumor susceptibility 101 |
| VEGFA | vascular endothelial growth factor A |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 |
| ZMAT3 | zinc finger, matrin-type 3 |
| ZNF277 | zinc finger protein 277 |
| ZNF451 | zinc finger protein 451 |
| Symbol | Name |
|---|---|
| ABAT | 4-aminobutyrate aminotransferase |
| ACOT7 | acyl-CoA thioesterase 7 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E |
| AQP1 | aquaporin 1 (Colton blood group) |
| ATAD2 | ATPase family, AAA domain containing 2 |
| AURKB | aurora kinase B |
| BIRC5 | baculoviral IAP repeat containing 5 |
| BMP2 | bone morphogenetic protein 2 |
| BST2 | bone marrow stromal cell antigen 2 |
| C1QBP | complement component 1, q subcomponent binding protein |
| C3 | complement component 3 |
| CCL2 | chemokine (C-C motif) ligand 2 |
| CCNA2 | cyclin A2 |
| CCND1 | cyclin D1 |
| CCND2 | cyclin D2 |
| CCR2 | chemokine (C-C motif) receptor 2 |
| CDC20 | cell division cycle 20 |
| CDC25A | cell division cycle 25A |
| CDC42 | cell division cycle 42 |
| CDC7 | cell division cycle 7 |
| CDCA3 | cell division cycle associated 3 |
| CDK1 | cyclin-dependent kinase 1 |
| CDK2AP1 | cyclin-dependent kinase 2 associated protein 1 |
| CDKN2C | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) |
| CDKN3 | cyclin-dependent kinase inhibitor 3 |
| CENPA | centromere protein A |
| CKLF | chemokine-like factor |
| CKS2 | CDC28 protein kinase regulatory subunit 2 |
| CLU | clusterin |
| COL4A6 | collagen, type IV, alpha 6 |
| CORO1A | coronin, actin binding protein, 1A |
| CPE | carboxypeptidase E |
| CSF2RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) |
| CTPS1 | CTP synthase 1 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 |
| DCK | deoxycytidine kinase |
| DNM1L | dynamin 1-like |
| DSCC1 | DNA replication and sister chromatid cohesion 1 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
| DUT | deoxyuridine triphosphatase |
| EBP | emopamil binding protein (sterol isomerase) |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) |
| FEN1 | flap structure-specific endonuclease 1 |
| FGFR3 | fibroblast growth factor receptor 3 |
| FGL2 | fibrinogen-like 2 |
| FHL1 | four and a half LIM domains 1 |
| FOXM1 | forkhead box M1 |
| FXYD6 | FXYD domain containing ion transport regulator 6 |
| GCLM | glutamate-cysteine ligase, modifier subunit |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) |
| GPX3 | glutathione peroxidase 3 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 |
| HIST1H4C | histone cluster 1, H4c |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 |
| HLF | hepatic leukemia factor |
| HMGB1 | high mobility group box 1 |
| HMGN2 | high mobility group nucleosomal binding domain 2 |
| HNRNPA0 | heterogeneous nuclear ribonucleoprotein A0 |
| HSPA1A | heat shock 70kDa protein 1A |
| HSPH1 | heat shock 105kDa/110kDa protein 1 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa |
| IGHD | immunoglobulin heavy constant delta |
| IGHM | immunoglobulin heavy constant mu |
| IGKC | immunoglobulin kappa constant |
| IGKV1-5 | immunoglobulin kappa variable 1-5 |
| IGKV4-1 | immunoglobulin kappa variable 4-1 |
| IGL | immunoglobulin lambda locus |
| IGLJ3 | immunoglobulin lambda joining 3 |
| IGLL3P | immunoglobulin lambda-like polypeptide 3, pseudogene |
| IGLV2-23 | immunoglobulin lambda variable 2-23 |
| IGLV3-19 | immunoglobulin lambda variable 3-19 |
| JAG1 | jagged 1 |
| JCHAIN | joining chain of multimeric IgA and IgM |
| KIAA0101 | KIAA0101 |
| KIF18B | kinesin family member 18B |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) |
| KRT13 | keratin 13, type I |
| KRT5 | keratin 5, type II |
| KRT6B | keratin 6B, type II |
| LAGE3 | L antigen family, member 3 |
| LAPTM4B | lysosomal protein transmembrane 4 beta |
| LAPTM5 | lysosomal protein transmembrane 5 |
| LMNB1 | lamin B1 |
| LMNB2 | lamin B2 |
| LMO3 | LIM domain only 3 (rhombotin-like 2) |
| LMO4 | LIM domain only 4 |
| LTF | lactotransferrin |
| MAOA | monoamine oxidase A |
| MAOB | monoamine oxidase B |
| MCM10 | minichromosome maintenance complex component 10 |
| MCM2 | minichromosome maintenance complex component 2 |
| MCM3 | minichromosome maintenance complex component 3 |
| MCM4 | minichromosome maintenance complex component 4 |
| MCM6 | minichromosome maintenance complex component 6 |
| MED21 | mediator complex subunit 21 |
| MGP | matrix Gla protein |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 |
| MKI67 | marker of proliferation Ki-67 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 |
| MYCBP | MYC binding protein |
| NCAM1 | neural cell adhesion molecule 1 |
| NCAPG | non-SMC condensin I complex, subunit G |
| NDC80 | NDC80 kinetochore complex component |
| NFIB | nuclear factor I/B |
| NMU | neuromedin U |
| NUSAP1 | nucleolar and spindle associated protein 1 |
| OIP5 | Opa interacting protein 5 |
| PAFAH1B3 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) |
| PARP2 | poly (ADP-ribose) polymerase 2 |
| PBK | PDZ binding kinase |
| PCOLCE2 | procollagen C-endopeptidase enhancer 2 |
| PEG10 | paternally expressed 10 |
| PFAS | phosphoribosylformylglycinamidine synthase |
| PFN2 | profilin 2 |
| PHGDH | phosphoglycerate dehydrogenase |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
| PLAC8 | placenta-specific 8 |
| POLR2E | polymerase (RNA) II (DNA directed) polypeptide E, 25kDa |
| POLR3K | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa |
| POSTN | periostin, osteoblast specific factor |
| PPIC | peptidylprolyl isomerase C (cyclophilin C) |
| PRMT1 | protein arginine methyltransferase 1 |
| PRPS1 | phosphoribosyl pyrophosphate synthetase 1 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) |
| RAD51AP1 | RAD51 associated protein 1 |
| RANBP1 | RAN binding protein 1 |
| RCAN2 | regulator of calcineurin 2 |
| RFC3 | replication factor C (activator 1) 3, 38kDa |
| RGS5 | regulator of G-protein signaling 5 |
| RRM2 | ribonucleotide reductase M2 |
| RTN1 | reticulon 1 |
| S100A2 | S100 calcium binding protein A2 |
| SAMHD1 | SAM domain and HD domain 1 |
| SAP30 | Sin3A-associated protein, 30kDa |
| SDC2 | syndecan 2 |
| SDF2L1 | stromal cell-derived factor 2-like 1 |
| SFN | stratifin |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase |
| SMC1A | structural maintenance of chromosomes 1A |
| SMC2 | structural maintenance of chromosomes 2 |
| SMC4 | structural maintenance of chromosomes 4 |
| SPC25 | SPC25, NDC80 kinetochore complex component |
| SPRR1A | small proline-rich protein 1A |
| SRM | spermidine synthase |
| STIP1 | stress-induced phosphoprotein 1 |
| STMN1 | stathmin 1 |
| SULF1 | sulfatase 1 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) |
| TACC3 | transforming, acidic coiled-coil containing protein 3 |
| TFDP1 | transcription factor Dp-1 |
| TMEM97 | transmembrane protein 97 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa |
| TPM1 | tropomyosin 1 (alpha) |
| TPX2 | TPX2, microtubule-associated |
| TRMT5 | tRNA methyltransferase 5 |
| TUBB | tubulin, beta class I |
| TUBG1 | tubulin, gamma 1 |
| TYMS | thymidylate synthetase |
| UBE2C | ubiquitin-conjugating enzyme E2C |
| UBE2S | ubiquitin-conjugating enzyme E2S |
| VRK1 | vaccinia related kinase 1 |
| WHSC1 | Wolf-Hirschhorn syndrome candidate 1 |
| ZEB1 | zinc finger E-box binding homeobox 1 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 |
| ZWINT | ZW10 interacting kinetochore protein |
