BRD-K68174511_torin-2_SKBR3_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K68174511_torin-2_SKBR3_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADM adrenomedullin
AGTR1 angiotensin II receptor, type 1
ANK2 ankyrin 2, neuronal
ANKRD10 ankyrin repeat domain 10
ARID5B AT rich interactive domain 5B (MRF1-like)
AURKA aurora kinase A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BPHL biphenyl hydrolase-like (serine hydrolase)
C6ORF48 chromosome 6 open reading frame 48
CALD1 caldesmon 1
CAPN3 calpain 3, (p94)
CCNF cyclin F
CCNG2 cyclin G2
CDK12 cyclin-dependent kinase 12
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CENPE centromere protein E, 312kDa
DENND2D DENN/MADD domain containing 2D
EGF epidermal growth factor
ELANE elastase, neutrophil expressed
ERAP2 endoplasmic reticulum aminopeptidase 2
GPM6B glycoprotein M6B
GRB7 growth factor receptor-bound protein 7
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HMGB2 high mobility group box 2
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
KAT6B K(lysine) acetyltransferase 6B
KDM3A lysine (K)-specific demethylase 3A
KIAA0355 KIAA0355
KIAA0907 KIAA0907
KIF20A kinesin family member 20A
LEF1 lymphoid enhancer-binding factor 1
MAMLD1 mastermind-like domain containing 1
METTL7A methyltransferase like 7A
NOTCH2NL notch 2 N-terminal like
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RSRP1 arginine/serine-rich protein 1
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SFRP1 secreted frizzled-related protein 1
SLC16A4 solute carrier family 16, member 4
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
TATDN2 TatD DNase domain containing 2
TBC1D31 TBC1 domain family, member 31
TBX3 T-box 3
TFF1 trefoil factor 1
TGIF1 TGFB-induced factor homeobox 1
TOM1L1 target of myb1 (chicken)-like 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRA2A transformer 2 alpha homolog (Drosophila)
TSC22D3 TSC22 domain family, member 3
TSPAN5 tetraspanin 5
VCAN versican
XIST X inactive specific transcript (non-protein coding)
ZHX2 zinc fingers and homeoboxes 2
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ADA adenosine deaminase
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AIF1 allograft inflammatory factor 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANOS1 anosmin 1
BEX4 brain expressed, X-linked 4
CCND2 cyclin D2
CCNE2 cyclin E2
CD9 CD9 molecule
CDC25A cell division cycle 25A
COL1A1 collagen, type I, alpha 1
COLEC12 collectin sub-family member 12
CSTA cystatin A (stefin A)
CTSZ cathepsin Z
CYB5A cytochrome b5 type A (microsomal)
DEGS1 delta(4)-desaturase, sphingolipid 1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
GNAS GNAS complex locus
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HDGFRP3 hepatoma-derived growth factor, related protein 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ISG15 ISG15 ubiquitin-like modifier
JAG1 jagged 1
KLF4 Kruppel-like factor 4 (gut)
LAMP3 lysosomal-associated membrane protein 3
LAPTM5 lysosomal protein transmembrane 5
LSP1 lymphocyte-specific protein 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAT2A methionine adenosyltransferase II, alpha
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIP7 NIP7, nucleolar pre-rRNA processing protein
PECAM1 platelet/endothelial cell adhesion molecule 1
PTPRO protein tyrosine phosphatase, receptor type, O
RAD51C RAD51 paralog C
REEP1 receptor accessory protein 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFN stratifin
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC43A3 solute carrier family 43, member 3
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TACC1 transforming, acidic coiled-coil containing protein 1
VASP vasodilator-stimulated phosphoprotein
WBP5 WW domain binding protein 5
Funding