BRD-K68185022_Ursolic Acid_AGS_6.0_h_70.07_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K68185022_Ursolic Acid_AGS_6.0_h_70.07_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM9 ADAM metallopeptidase domain 9
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CALD1 caldesmon 1
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CFB complement factor B
CFI complement factor I
CHEK1 checkpoint kinase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLIC5 chloride intracellular channel 5
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
CXCL5 chemokine (C-X-C motif) ligand 5
CYTIP cytohesin 1 interacting protein
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
EPAS1 endothelial PAS domain protein 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
G0S2 G0/G1 switch 2
GRB7 growth factor receptor-bound protein 7
GUSBP11 glucuronidase, beta pseudogene 11
GUSBP3 glucuronidase, beta pseudogene 3
HBB hemoglobin, beta
HBP1 HMG-box transcription factor 1
HCAR3 hydroxycarboxylic acid receptor 3
HILPDA hypoxia inducible lipid droplet-associated
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGB1 high mobility group box 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
KRT5 keratin 5, type II
KYNU kynureninase
LPL lipoprotein lipase
LTB lymphotoxin beta (TNF superfamily, member 3)
LTF lactotransferrin
LYPD1 LY6/PLAUR domain containing 1
MCAM melanoma cell adhesion molecule
MECOM MDS1 and EVI1 complex locus
MMD monocyte to macrophage differentiation-associated
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
MUC16 mucin 16, cell surface associated
MUC4 mucin 4, cell surface associated
NGRN neugrin, neurite outgrowth associated
NPIPB3 nuclear pore complex interacting protein family, member B3
OPTN optineurin
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PKM pyruvate kinase, muscle
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCD protein kinase C, delta
PRR15L proline rich 15-like
RBM3 RNA binding motif (RNP1, RRM) protein 3
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRAD Ras-related associated with diabetes
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SNN stannin
SPP1 secreted phosphoprotein 1
SQLE squalene epoxidase
SSPN sarcospan
THY1 Thy-1 cell surface antigen
TMC5 transmembrane channel-like 5
TMPRSS3 transmembrane protease, serine 3
TPM4 tropomyosin 4
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ATF6 activating transcription factor 6
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CLIC4 chloride intracellular channel 4
CXCL9 chemokine (C-X-C motif) ligand 9
DLC1 DLC1 Rho GTPase activating protein
DST dystonin
DUSP6 dual specificity phosphatase 6
EPHA3 EPH receptor A3
ERBB2 erb-b2 receptor tyrosine kinase 2
GCH1 GTP cyclohydrolase 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HOXC6 homeobox C6
HSPB8 heat shock 22kDa protein 8
ITM2A integral membrane protein 2A
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KLF4 Kruppel-like factor 4 (gut)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MACF1 microtubule-actin crosslinking factor 1
MAP7 microtubule-associated protein 7
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PCCB propionyl CoA carboxylase, beta polypeptide
PHACTR2 phosphatase and actin regulator 2
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRR7 proline rich 7 (synaptic)
PTPRD protein tyrosine phosphatase, receptor type, D
RCAN1 regulator of calcineurin 1
RGS4 regulator of G-protein signaling 4
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RUFY3 RUN and FYVE domain containing 3
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
TESC tescalcin
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TPD52L1 tumor protein D52-like 1
Funding