BRD-K68185022_Ursolic Acid_HCC515_24.0_h_70.07_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

52 genes differentially expressed following the BRD-K68185022_Ursolic Acid_HCC515_24.0_h_70.07_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BTG1 B-cell translocation gene 1, anti-proliferative
CTSL cathepsin L
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DDIT3 DNA-damage-inducible transcript 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP6 dual specificity phosphatase 6
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FADS3 fatty acid desaturase 3
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAGE3 G antigen 3
GARS glycyl-tRNA synthetase
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
INSIG1 insulin induced gene 1
KIAA0226L KIAA0226-like
LIMCH1 LIM and calponin homology domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOA monoamine oxidase A
MTSS1 metastasis suppressor 1
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIR pirin (iron-binding nuclear protein)
PTX3 pentraxin 3, long
PYCR1 pyrroline-5-carboxylate reductase 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCN3A sodium channel, voltage gated, type III alpha subunit
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
XBP1 X-box binding protein 1
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
DCXR dicarbonyl/L-xylulose reductase
IGFBP7 insulin-like growth factor binding protein 7
MCM6 minichromosome maintenance complex component 6
RBP1 retinol binding protein 1, cellular
SORD sorbitol dehydrogenase
Funding