BRD-K68185022_Ursolic Acid_WSUDLCL2_6.0_h_70.07_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

147 genes differentially expressed following the BRD-K68185022_Ursolic Acid_WSUDLCL2_6.0_h_70.07_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
APLP1 amyloid beta (A4) precursor-like protein 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOD apolipoprotein D
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BACE2 beta-site APP-cleaving enzyme 2
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL5 chemokine (C-C motif) ligand 5
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
COL6A2 collagen, type VI, alpha 2
CPA3 carboxypeptidase A3 (mast cell)
CPB1 carboxypeptidase B1 (tissue)
CXCL10 chemokine (C-X-C motif) ligand 10
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DEPTOR DEP domain containing MTOR-interacting protein
DLC1 DLC1 Rho GTPase activating protein
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DPT dermatopontin
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ETV5 ets variant 5
EXT1 exostosin glycosyltransferase 1
FAM171A1 family with sequence similarity 171, member A1
FAM69A family with sequence similarity 69, member A
FBLN1 fibulin 1
FGF13 fibroblast growth factor 13
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
FOXF2 forkhead box F2
GNAS GNAS complex locus
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GPRC5B G protein-coupled receptor, class C, group 5, member B
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HDAC9 histone deacetylase 9
HES1 hes family bHLH transcription factor 1
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS8 lectin, galactoside-binding, soluble, 8
LPAR1 lysophosphatidic acid receptor 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MDFIC MyoD family inhibitor domain containing
MDK midkine (neurite growth-promoting factor 2)
MEIS2 Meis homeobox 2
NLRP2 NLR family, pyrin domain containing 2
NRCAM neuronal cell adhesion molecule
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PBLD phenazine biosynthesis-like protein domain containing
PEX11A peroxisomal biogenesis factor 11 alpha
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNMA2 paraneoplastic Ma antigen 2
PRKCQ protein kinase C, theta
PSD3 pleckstrin and Sec7 domain containing 3
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PXMP2 peroxisomal membrane protein 2, 22kDa
RGS2 regulator of G-protein signaling 2
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SESN1 sestrin 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SGK1 serum/glucocorticoid regulated kinase 1
SH3GL3 SH3-domain GRB2-like 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT4 signal transducer and activator of transcription 4
STC2 stanniocalcin 2
TBL1X transducin (beta)-like 1X-linked
TFEC transcription factor EC
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR3 transforming growth factor, beta receptor III
THBS2 thrombospondin 2
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB3 tribbles pseudokinase 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
VEGFA vascular endothelial growth factor A
ZNF586 zinc finger protein 586
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C1ORF116 chromosome 1 open reading frame 116
CDA cytidine deaminase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHRDL1 chordin-like 1
CTNND1 catenin (cadherin-associated protein), delta 1
EDNRA endothelin receptor type A
ELF5 E74-like factor 5 (ets domain transcription factor)
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBXO11 F-box protein 11
FKBP14 FK506 binding protein 14, 22 kDa
FPR1 formyl peptide receptor 1
GSTP1 glutathione S-transferase pi 1
HSPA1A heat shock 70kDa protein 1A
IGFBP4 insulin-like growth factor binding protein 4
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IL1R2 interleukin 1 receptor, type II
IL1RN interleukin 1 receptor antagonist
KCTD12 potassium channel tetramerization domain containing 12
KRT14 keratin 14, type I
LAPTM5 lysosomal protein transmembrane 5
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MINA MYC induced nuclear antigen
MNDA myeloid cell nuclear differentiation antigen
NAV2 neuron navigator 2
PALLD palladin, cytoskeletal associated protein
PELI1 pellino E3 ubiquitin protein ligase 1
PI3 peptidase inhibitor 3, skin-derived
PKP1 plakophilin 1
PLAC8 placenta-specific 8
PODXL podocalyxin-like
PTPRC protein tyrosine phosphatase, receptor type, C
RAD51C RAD51 paralog C
RPIA ribose 5-phosphate isomerase A
RUNX1 runt-related transcription factor 1
SERBP1 SERPINE1 mRNA binding protein 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC43A3 solute carrier family 43, member 3
SMCO4 single-pass membrane protein with coiled-coil domains 4
SORD sorbitol dehydrogenase
SPRR2B small proline-rich protein 2B
SSBP2 single-stranded DNA binding protein 2
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D4 TBC1 domain family, member 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFF3 trefoil factor 3 (intestinal)
TLR4 toll-like receptor 4
TSPAN4 tetraspanin 4
VNN1 vanin 1
ZBTB18 zinc finger and BTB domain containing 18
Funding