BRD-K68191783_ALW-II-38-3_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K68191783_ALW-II-38-3_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA3 annexin A3
BMI1 BMI1 proto-oncogene, polycomb ring finger
C2CD2 C2 calcium-dependent domain containing 2
CD58 CD58 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHRDL1 chordin-like 1
COL4A5 collagen, type IV, alpha 5
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DUSP6 dual specificity phosphatase 6
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FAM171A1 family with sequence similarity 171, member A1
ICAM2 intercellular adhesion molecule 2
IER3 immediate early response 3
ITGA6 integrin, alpha 6
KRT19 keratin 19, type I
LAMC2 laminin, gamma 2
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS1 lectin, galactoside-binding, soluble, 1
MT1E metallothionein 1E
NFIB nuclear factor I/B
NQO1 NAD(P)H dehydrogenase, quinone 1
ODC1 ornithine decarboxylase 1
PDLIM4 PDZ and LIM domain 4
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PLAT plasminogen activator, tissue
PRAME preferentially expressed antigen in melanoma
PROCR protein C receptor, endothelial
RPS5 ribosomal protein S5
SATB1 SATB homeobox 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SOX4 SRY (sex determining region Y)-box 4
SRPX sushi-repeat containing protein, X-linked
STOM stomatin
TGFBR3 transforming growth factor, beta receptor III
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIK TRAF2 and NCK interacting kinase
TOMM34 translocase of outer mitochondrial membrane 34

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AQP9 aquaporin 9
ASS1 argininosuccinate synthase 1
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BPHL biphenyl hydrolase-like (serine hydrolase)
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CBS cystathionine-beta-synthase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CECR1 cat eye syndrome chromosome region, candidate 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CXCL9 chemokine (C-X-C motif) ligand 9
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCN decorin
EGR2 early growth response 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
GLUL glutamate-ammonia ligase
GRB14 growth factor receptor-bound protein 14
GSE1 Gse1 coiled-coil protein
GSTA1 glutathione S-transferase alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MME membrane metallo-endopeptidase
MMP2 matrix metallopeptidase 2
MSH6 mutS homolog 6
NIT1 nitrilase 1
NQO2 NAD(P)H dehydrogenase, quinone 2
PAPD7 PAP associated domain containing 7
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PPAP2B phosphatidic acid phosphatase type 2B
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SORBS2 sorbin and SH3 domain containing 2
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TM9SF3 transmembrane 9 superfamily member 3
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TUBB2B tubulin, beta 2B class IIb
VDAC1 voltage-dependent anion channel 1
WDR7 WD repeat domain 7
Funding