BRD-K68191783_ALW-II-38-3_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K68191783_ALW-II-38-3_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ANXA3 annexin A3
BAG2 BCL2-associated athanogene 2
C6ORF48 chromosome 6 open reading frame 48
C8ORF4 chromosome 8 open reading frame 4
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COTL1 coactosin-like F-actin binding protein 1
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DST dystonin
EDNRB endothelin receptor type B
GSTM3 glutathione S-transferase mu 3 (brain)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
LAPTM4B lysosomal protein transmembrane 4 beta
LXN latexin
MAP1B microtubule-associated protein 1B
MARCKSL1 MARCKS-like 1
MFSD10 major facilitator superfamily domain containing 10
MMP7 matrix metallopeptidase 7
NTS neurotensin
PCP4 Purkinje cell protein 4
PLAT plasminogen activator, tissue
PMP22 peripheral myelin protein 22
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
PRSS2 protease, serine, 2 (trypsin 2)
RCAN1 regulator of calcineurin 1
RPL36 ribosomal protein L36
SELL selectin L
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SRPX sushi-repeat containing protein, X-linked
TFF1 trefoil factor 1
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AK4 adenylate kinase 4
CA12 carbonic anhydrase XII
CD24 CD24 molecule
CD52 CD52 molecule
CD9 CD9 molecule
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CYBB cytochrome b-245, beta polypeptide
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
EZR ezrin
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HTRA1 HtrA serine peptidase 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP7 insulin-like growth factor binding protein 7
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IPO13 importin 13
JCHAIN joining chain of multimeric IgA and IgM
KRT14 keratin 14, type I
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
METTL7A methyltransferase like 7A
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP2 matrix metallopeptidase 2
MSH6 mutS homolog 6
MTSS1 metastasis suppressor 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
PAPD7 PAP associated domain containing 7
PAX5 paired box 5
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PTPRO protein tyrosine phosphatase, receptor type, O
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
S100A7 S100 calcium binding protein A7
SCAND1 SCAN domain containing 1
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHB Src homology 2 domain containing adaptor protein B
SPINK1 serine peptidase inhibitor, Kazal type 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS2 thrombospondin 2
TM9SF3 transmembrane 9 superfamily member 3
ZNF395 zinc finger protein 395
Funding