BRD-K68313733_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

227 genes differentially expressed following the BRD-K68313733_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABHD4 abhydrolase domain containing 4
ACADVL acyl-CoA dehydrogenase, very long chain
ADM adrenomedullin
ALDOC aldolase C, fructose-bisphosphate
ARC activity-regulated cytoskeleton-associated protein
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
CALR calreticulin
CASP7 caspase 7, apoptosis-related cysteine peptidase
CBS cystathionine-beta-synthase
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLU clusterin
CRABP2 cellular retinoic acid binding protein 2
CTH cystathionine gamma-lyase
CTSL cathepsin L
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSG3 desmoglein 3
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP22 dual specificity phosphatase 22
DUSP5 dual specificity phosphatase 5
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPS8L1 EPS8-like 1
FBN2 fibrillin 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCLM glutamate-cysteine ligase, modifier subunit
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HCAR3 hydroxycarboxylic acid receptor 3
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IGFBP3 insulin-like growth factor binding protein 3
IL11 interleukin 11
IL6 interleukin 6
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
KLK10 kallikrein-related peptidase 10
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KTN1 kinectin 1 (kinesin receptor)
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MDK midkine (neurite growth-promoting factor 2)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MINK1 misshapen-like kinase 1
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
MSX1 msh homeobox 1
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFML2A olfactomedin-like 2A
PDGFRL platelet-derived growth factor receptor-like
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PKP1 plakophilin 1
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMP22 peripheral myelin protein 22
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RRAD Ras-related associated with diabetes
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELE selectin E
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SERTAD2 SERTA domain containing 2
SFN stratifin
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
SPRR1A small proline-rich protein 1A
SPRR2B small proline-rich protein 2B
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
THBD thrombomodulin
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNNT1 troponin T type 1 (skeletal, slow)
TRIB1 tribbles pseudokinase 1
TRIM16 tripartite motif containing 16
TXNRD1 thioredoxin reductase 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WISP2 WNT1 inducible signaling pathway protein 2
XIST X inactive specific transcript (non-protein coding)
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACSL5 acyl-CoA synthetase long-chain family member 5
ADGRG6 adhesion G protein-coupled receptor G6
AIM1 absent in melanoma 1
AKAP7 A kinase (PRKA) anchor protein 7
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
AURKA aurora kinase A
B3GNT1
C7 complement component 7
CALD1 caldesmon 1
CCNA2 cyclin A2
CCND1 cyclin D1
CD200 CD200 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CKAP4 cytoskeleton-associated protein 4
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTSH cathepsin H
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAAF2 dynein, axonemal, assembly factor 2
DTX4 deltex 4, E3 ubiquitin ligase
DUSP6 dual specificity phosphatase 6
ERBB3 erb-b2 receptor tyrosine kinase 3
F5 coagulation factor V (proaccelerin, labile factor)
FABP4 fatty acid binding protein 4, adipocyte
FANCF Fanconi anemia, complementation group F
FBXO9 F-box protein 9
FXYD2 FXYD domain containing ion transport regulator 2
GSPT2 G1 to S phase transition 2
HOXA10 homeobox A10
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGHM immunoglobulin heavy constant mu
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
JADE2 jade family PHD finger 2
KIF1BP KIF1 binding protein
KLHL9 kelch-like family member 9
KRT7 keratin 7, type II
LCMT2 leucine carboxyl methyltransferase 2
LYZ lysozyme
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED1 melanoma antigen family D1
MGP matrix Gla protein
MRPL15 mitochondrial ribosomal protein L15
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NRIP1 nuclear receptor interacting protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PPARG peroxisome proliferator-activated receptor gamma
PROM1 prominin 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF6 serine/arginine-rich splicing factor 6
SUOX sulfite oxidase
TBC1D4 TBC1 domain family, member 4
TIMP3 TIMP metallopeptidase inhibitor 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMX4 thioredoxin-related transmembrane protein 4
TNS3 tensin 3
UNC50 unc-50 homolog (C. elegans)
VCAN versican
ZBED5 zinc finger, BED-type containing 5
ZBTB18 zinc finger and BTB domain containing 18
Funding