BRD-K68437527_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-K68437527_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AARS alanyl-tRNA synthetase
ADGRG6 adhesion G protein-coupled receptor G6
AKR1C3 aldo-keto reductase family 1, member C3
BTG1 B-cell translocation gene 1, anti-proliferative
CA2 carbonic anhydrase II
CCNA1 cyclin A1
CDC20 cell division cycle 20
CLCA2 chloride channel accessory 2
CTSZ cathepsin Z
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
FBLN1 fibulin 1
HMG20B high mobility group 20B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KRT17 keratin 17, type I
KRT81 keratin 81, type II
NQO1 NAD(P)H dehydrogenase, quinone 1
PKM pyruvate kinase, muscle
PLK1 polo-like kinase 1
PPAP2B phosphatidic acid phosphatase type 2B
RAB13 RAB13, member RAS oncogene family
SCGB1D2 secretoglobin, family 1D, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TMEM2 transmembrane protein 2
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALCAM activated leukocyte cell adhesion molecule
ANOS1 anosmin 1
ARHGAP29 Rho GTPase activating protein 29
AUTS2 autism susceptibility candidate 2
BHLHE41 basic helix-loop-helix family, member e41
CCND1 cyclin D1
CCND2 cyclin D2
CELF2 CUGBP, Elav-like family member 2
CFB complement factor B
CLIC4 chloride intracellular channel 4
CNN3 calponin 3, acidic
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
CYR61 cysteine-rich, angiogenic inducer, 61
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLC1 DLC1 Rho GTPase activating protein
DPYSL3 dihydropyrimidinase-like 3
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FERMT2 fermitin family member 2
FOSL1 FOS-like antigen 1
GADD45B growth arrest and DNA-damage-inducible, beta
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
INHBA inhibin, beta A
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP9 matrix metallopeptidase 9
MRPS30 mitochondrial ribosomal protein S30
MSLN mesothelin
MSMO1 methylsterol monooxygenase 1
MXRA7 matrix-remodelling associated 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NUAK1 NUAK family, SNF1-like kinase, 1
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDGFA platelet-derived growth factor alpha polypeptide
PKP2 plakophilin 2
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PODXL podocalyxin-like
PRSS23 protease, serine, 23
RBP1 retinol binding protein 1, cellular
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RHOBTB3 Rho-related BTB domain containing 3
RND3 Rho family GTPase 3
S100A10 S100 calcium binding protein A10
SCG2 secretogranin II
SCG5 secretogranin V
THBS1 thrombospondin 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Funding