BRD-K68548958_-666_HEPG2_6.0_h_20.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K68548958_-666_HEPG2_6.0_h_20.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM1 absent in melanoma 1
AQP1 aquaporin 1 (Colton blood group)
BAG3 BCL2-associated athanogene 3
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD40 CD40 molecule, TNF receptor superfamily member 5
CD52 CD52 molecule
CD93 CD93 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK14 cyclin-dependent kinase 14
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EPAS1 endothelial PAS domain protein 1
FABP6 fatty acid binding protein 6, ileal
FAM69A family with sequence similarity 69, member A
FGFR2 fibroblast growth factor receptor 2
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGHM immunoglobulin heavy constant mu
IPO13 importin 13
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITM2C integral membrane protein 2C
JCHAIN joining chain of multimeric IgA and IgM
KCTD5 potassium channel tetramerization domain containing 5
KIAA0930 KIAA0930
MMP2 matrix metallopeptidase 2
MNDA myeloid cell nuclear differentiation antigen
MT1F metallothionein 1F
NCAPD2 non-SMC condensin I complex, subunit D2
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NRGN neurogranin (protein kinase C substrate, RC3)
NT5E 5'-nucleotidase, ecto (CD73)
PADI2 peptidyl arginine deiminase, type II
PECAM1 platelet/endothelial cell adhesion molecule 1
PLVAP plasmalemma vesicle associated protein
PLXNB2 plexin B2
PPOX protoporphyrinogen oxidase
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
RAB27A RAB27A, member RAS oncogene family
RNASE6 ribonuclease, RNase A family, k6
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SHB Src homology 2 domain containing adaptor protein B
SIRPA signal-regulatory protein alpha
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
ST18 suppression of tumorigenicity 18, zinc finger
STC1 stanniocalcin 1
SYT1 synaptotagmin I
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TRIB2 tribbles pseudokinase 2
TRIB3 tribbles pseudokinase 3
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ALDOA aldolase A, fructose-bisphosphate
DKK1 dickkopf WNT signaling pathway inhibitor 1
F3 coagulation factor III (thromboplastin, tissue factor)
FLRT2 fibronectin leucine rich transmembrane protein 2
GNAS GNAS complex locus
HEXIM1 hexamethylene bis-acetamide inducible 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
LAPTM4B lysosomal protein transmembrane 4 beta
LUM lumican
MARCKSL1 MARCKS-like 1
MIR22HG MIR22 host gene
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PEBP1 phosphatidylethanolamine binding protein 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
RABGAP1 RAB GTPase activating protein 1
SFN stratifin
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SORD sorbitol dehydrogenase
TESC tescalcin
TFRC transferrin receptor
THBS1 thrombospondin 1
TSPAN3 tetraspanin 3
TUBB tubulin, beta class I
Funding