BRD-K68873215_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-K68873215_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADI1 acireductone dioxygenase 1
ADM adrenomedullin
ALDOC aldolase C, fructose-bisphosphate
APLP2 amyloid beta (A4) precursor-like protein 2
BST2 bone marrow stromal cell antigen 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHPT1 choline phosphotransferase 1
CTSB cathepsin B
ERBB2 erb-b2 receptor tyrosine kinase 2
EXOSC4 exosome component 4
FHL1 four and a half LIM domains 1
G6PD glucose-6-phosphate dehydrogenase
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HOXB6 homeobox B6
HSPA1A heat shock 70kDa protein 1A
IFI30 interferon, gamma-inducible protein 30
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
LRP2 low density lipoprotein receptor-related protein 2
LTF lactotransferrin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1C1 mannosidase, alpha, class 1C, member 1
MAP7 microtubule-associated protein 7
NDRG1 N-myc downstream regulated 1
NQO1 NAD(P)H dehydrogenase, quinone 1
PDLIM5 PDZ and LIM domain 5
QPRT quinolinate phosphoribosyltransferase
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS2 regulator of G-protein signaling 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
STC2 stanniocalcin 2

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CAST calpastatin
CCNF cyclin F
COPS7A COP9 signalosome subunit 7A
ESR1 estrogen receptor 1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT23 keratin 23, type I
MMP10 matrix metallopeptidase 10
NLGN4X neuroligin 4, X-linked
OLFM1 olfactomedin 1
OLFM4 olfactomedin 4
PXDN peroxidasin
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SNX7 sorting nexin 7
SPDEF SAM pointed domain containing ETS transcription factor
TGFBI transforming growth factor, beta-induced, 68kDa
THBS4 thrombospondin 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
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