BRD-K69840642_HDAC6 inhibitor ISOX_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

245 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ADGRF5 adhesion G protein-coupled receptor F5
ADRB2 adrenoceptor beta 2, surface
AGTPBP1 ATP/GTP binding protein 1
ALAS1 5'-aminolevulinate synthase 1
ALDOC aldolase C, fructose-bisphosphate
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANKRD46 ankyrin repeat domain 46
ANXA6 annexin A6
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASMTL acetylserotonin O-methyltransferase-like
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BLCAP bladder cancer associated protein
BZW2 basic leucine zipper and W2 domains 2
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCND3 cyclin D3
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CETN2 centrin, EF-hand protein, 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLC Charcot-Leyden crystal galectin
CLPTM1 cleft lip and palate associated transmembrane protein 1
CORO1A coronin, actin binding protein, 1A
CREG1 cellular repressor of E1A-stimulated genes 1
CSF1R colony stimulating factor 1 receptor
CSRP1 cysteine and glycine-rich protein 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYLD cylindromatosis (turban tumor syndrome)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCN decorin
DHCR7 7-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSTN destrin (actin depolymerizing factor)
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFHD1 EF-hand domain family, member D1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETHE1 ethylmalonic encephalopathy 1
EZR ezrin
F11R F11 receptor
FADS3 fatty acid desaturase 3
FAM107A family with sequence similarity 107, member A
FBXO3 F-box protein 3
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXO4 forkhead box O4
FYB FYN binding protein
G6PD glucose-6-phosphate dehydrogenase
GABARAPL2 GABA(A) receptor-associated protein-like 2
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GOLGA7 golgin A7
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GRHPR glyoxylate reductase/hydroxypyruvate reductase
GSDMB gasdermin B
GSN gelsolin
HECA headcase homolog (Drosophila)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HSDL2 hydroxysteroid dehydrogenase like 2
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP5 insulin-like growth factor binding protein 5
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KCTD5 potassium channel tetramerization domain containing 5
KIAA0226L KIAA0226-like
LAPTM5 lysosomal protein transmembrane 5
LBH limb bud and heart development
LIPA lipase A, lysosomal acid, cholesterol esterase
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MAOB monoamine oxidase B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MGST3 microsomal glutathione S-transferase 3
MPC1 mitochondrial pyruvate carrier 1
MPC2 mitochondrial pyruvate carrier 2
MSMO1 methylsterol monooxygenase 1
MSRB1 methionine sulfoxide reductase B1
MT1X metallothionein 1X
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MX1 MX dynamin-like GTPase 1
MYO6 myosin VI
NDRG1 N-myc downstream regulated 1
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NIT1 nitrilase 1
NOSIP nitric oxide synthase interacting protein
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PADI2 peptidyl arginine deiminase, type II
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDH9 protocadherin 9
PCYOX1L prenylcysteine oxidase 1 like
PEG10 paternally expressed 10
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLA2G15 phospholipase A2, group XV
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PRKCD protein kinase C, delta
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RABAC1 Rab acceptor 1 (prenylated)
RAD9A RAD9 homolog A (S. pombe)
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RGS10 regulator of G-protein signaling 10
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
ROGDI rogdi homolog (Drosophila)
RTN2 reticulon 2
RTN3 reticulon 3
S100A14 S100 calcium binding protein A14
S100P S100 calcium binding protein P
SCPEP1 serine carboxypeptidase 1
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SGK1 serum/glucocorticoid regulated kinase 1
SH3GLB2 SH3-domain GRB2-like endophilin B2
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLC46A3 solute carrier family 46, member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SRGN serglycin
STAB1 stabilin 1
STK17A serine/threonine kinase 17a
STOM stomatin
SYNGR2 synaptogyrin 2
TBXA2R thromboxane A2 receptor
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP3 TIMP metallopeptidase inhibitor 3
TNNT1 troponin T type 1 (skeletal, slow)
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TYROBP TYRO protein tyrosine kinase binding protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAT1 vesicle amine transport 1
VCL vinculin
WDTC1 WD and tetratricopeptide repeats 1
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AKAP8 A kinase (PRKA) anchor protein 8
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
AURKA aurora kinase A
BEX1 brain expressed, X-linked 1
C7ORF49 chromosome 7 open reading frame 49
CCND1 cyclin D1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
DCTD dCMP deaminase
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF4B eukaryotic translation initiation factor 4B
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EREG epiregulin
EXOSC4 exosome component 4
FAM57A family with sequence similarity 57, member A
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GAS2 growth arrest-specific 2
GATAD1 GATA zinc finger domain containing 1
GPX2 glutathione peroxidase 2
GSAP gamma-secretase activating protein
GSTO1 glutathione S-transferase omega 1
HMGA2 high mobility group AT-hook 2
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
IGFBP6 insulin-like growth factor binding protein 6
IGFBP7 insulin-like growth factor binding protein 7
ING3 inhibitor of growth family, member 3
IRAK1 interleukin-1 receptor-associated kinase 1
IRS2 insulin receptor substrate 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KIF18B kinesin family member 18B
KYNU kynureninase
LAMC1 laminin, gamma 1 (formerly LAMB2)
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LOX lysyl oxidase
LRRC41 leucine rich repeat containing 41
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MCTP1 multiple C2 domains, transmembrane 1
MECOM MDS1 and EVI1 complex locus
MICALL1 MICAL-like 1
MOK MOK protein kinase
NBN nibrin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NMT1 N-myristoyltransferase 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP50 nucleoporin 50kDa
OBSL1 obscurin-like 1
PARVB parvin, beta
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
S100A2 S100 calcium binding protein A2
SEPHS1 selenophosphate synthetase 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNRPE small nuclear ribonucleoprotein polypeptide E
STC2 stanniocalcin 2
SUMO3 small ubiquitin-like modifier 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TFDP1 transcription factor Dp-1
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TMF1 TATA element modulatory factor 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TWIST1 twist family bHLH transcription factor 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
USP22 ubiquitin specific peptidase 22
VCAN versican
ZMYND11 zinc finger, MYND-type containing 11
Funding