BRD-K69840642_HDAC6 inhibitor ISOX_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRA2 adhesion G protein-coupled receptor A2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC4 chloride intracellular channel 4
COL1A1 collagen, type I, alpha 1
CRABP2 cellular retinoic acid binding protein 2
EZR ezrin
FAM117A family with sequence similarity 117, member A
FGF9 fibroblast growth factor 9
FOXO4 forkhead box O4
HIST1H1C histone cluster 1, H1c
HLA-E major histocompatibility complex, class I, E
HMG20B high mobility group 20B
HMOX1 heme oxygenase 1
IGFBP5 insulin-like growth factor binding protein 5
KLF2 Kruppel-like factor 2
MAGEA6 melanoma antigen family A6
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NEB nebulin
NID2 nidogen 2 (osteonidogen)
NQO2 NAD(P)H dehydrogenase, quinone 2
OAT ornithine aminotransferase
OSR2 odd-skipped related transciption factor 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PLA2G15 phospholipase A2, group XV
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RHOB ras homolog family member B
ROGDI rogdi homolog (Drosophila)
SCGB2A2 secretoglobin, family 2A, member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNN stannin
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STAR steroidogenic acute regulatory protein
TCTA T-cell leukemia translocation altered
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUBB2A tubulin, beta 2A class IIa
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
AGR2 anterior gradient 2
ANXA1 annexin A1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
AURKA aurora kinase A
BAG2 BCL2-associated athanogene 2
BASP1 brain abundant, membrane attached signal protein 1
CCNA2 cyclin A2
CCND1 cyclin D1
CDK1 cyclin-dependent kinase 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CKS2 CDC28 protein kinase regulatory subunit 2
CRYZ crystallin, zeta (quinone reductase)
CXCL8 chemokine (C-X-C motif) ligand 8
DARS aspartyl-tRNA synthetase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FAM57A family with sequence similarity 57, member A
FGB fibrinogen beta chain
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GJA1 gap junction protein, alpha 1, 43kDa
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPX2 glutathione peroxidase 2
HDGFRP3 hepatoma-derived growth factor, related protein 3
HOPX HOP homeobox
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD2 interferon-related developmental regulator 2
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIAA0101 KIAA0101
KIF14 kinesin family member 14
LXN latexin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM3 minichromosome maintenance complex component 3
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PGD phosphogluconate dehydrogenase
PLBD1 phospholipase B domain containing 1
PLS1 plastin 1
PON2 paraoxonase 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPS27L ribosomal protein S27-like
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SORBS3 sorbin and SH3 domain containing 3
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TEX10 testis expressed 10
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TSPAN8 tetraspanin 8
UBE2C ubiquitin-conjugating enzyme E2C
ZNHIT3 zinc finger, HIT-type containing 3
ZWINT ZW10 interacting kinetochore protein
Funding