| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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308 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| AAMDC | adipogenesis associated, Mth938 domain containing |
| ACOT7 | acyl-CoA thioesterase 7 |
| ADCY9 | adenylate cyclase 9 |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
| ALAD | aminolevulinate dehydratase |
| ALDOC | aldolase C, fructose-bisphosphate |
| ANKRD46 | ankyrin repeat domain 46 |
| ANXA6 | annexin A6 |
| ASMTL | acetylserotonin O-methyltransferase-like |
| ATG2A | autophagy related 2A |
| ATP2A3 | ATPase, Ca++ transporting, ubiquitous |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D |
| AVIL | advillin |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like |
| BZW2 | basic leucine zipper and W2 domains 2 |
| CA2 | carbonic anhydrase II |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) |
| CD9 | CD9 molecule |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
| CHN2 | chimerin 2 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 |
| CORO1A | coronin, actin binding protein, 1A |
| CPD | carboxypeptidase D |
| CTH | cystathionine gamma-lyase |
| CTSA | cathepsin A |
| CYB5R1 | cytochrome b5 reductase 1 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 |
| CYLD | cylindromatosis (turban tumor syndrome) |
| DCN | decorin |
| DHCR7 | 7-dehydrocholesterol reductase |
| DLK1 | delta-like 1 homolog (Drosophila) |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 |
| DUSP14 | dual specificity phosphatase 14 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 |
| EFHD1 | EF-hand domain family, member D1 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 |
| FABP1 | fatty acid binding protein 1, liver |
| FADS3 | fatty acid desaturase 3 |
| FAM117A | family with sequence similarity 117, member A |
| FBP1 | fructose-1,6-bisphosphatase 1 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 |
| FN1 | fibronectin 1 |
| FOXO4 | forkhead box O4 |
| FUCA1 | fucosidase, alpha-L- 1, tissue |
| GCH1 | GTP cyclohydrolase 1 |
| GLRX | glutaredoxin (thioltransferase) |
| GLS | glutaminase |
| GM2A | GM2 ganglioside activator |
| GOT1 | glutamic-oxaloacetic transaminase 1, soluble |
| GSN | gelsolin |
| HECA | headcase homolog (Drosophila) |
| HLA-A | major histocompatibility complex, class I, A |
| HLA-B | major histocompatibility complex, class I, B |
| HSDL2 | hydroxysteroid dehydrogenase like 2 |
| HSPA1A | heat shock 70kDa protein 1A |
| HSPA2 | heat shock 70kDa protein 2 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 |
| IFI30 | interferon, gamma-inducible protein 30 |
| IFI6 | interferon, alpha-inducible protein 6 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa |
| IGFBP5 | insulin-like growth factor binding protein 5 |
| IGKV1-5 | immunoglobulin kappa variable 1-5 |
| INSIG1 | insulin induced gene 1 |
| IRF7 | interferon regulatory factor 7 |
| ISG15 | ISG15 ubiquitin-like modifier |
| ITM2A | integral membrane protein 2A |
| ITM2C | integral membrane protein 2C |
| KIAA1033 | KIAA1033 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein |
| LGMN | legumain |
| LIMA1 | LIM domain and actin binding 1 |
| LPIN1 | lipin 1 |
| LRCH4 | leucine-rich repeats and calponin homology (CH) domain containing 4 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta |
| MAPT | microtubule-associated protein tau |
| MBNL2 | muscleblind-like splicing regulator 2 |
| MICAL1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 |
| MLEC | malectin |
| MLF1 | myeloid leukemia factor 1 |
| MPC1 | mitochondrial pyruvate carrier 1 |
| MTUS1 | microtubule associated tumor suppressor 1 |
| MXRA7 | matrix-remodelling associated 7 |
| MZB1 | marginal zone B and B1 cell-specific protein |
| NANS | N-acetylneuraminic acid synthase |
| NDRG1 | N-myc downstream regulated 1 |
| NEFM | neurofilament, medium polypeptide |
| NEU1 | sialidase 1 (lysosomal sialidase) |
| NFIL3 | nuclear factor, interleukin 3 regulated |
| NOSIP | nitric oxide synthase interacting protein |
| NPC1 | Niemann-Pick disease, type C1 |
| NPC2 | Niemann-Pick disease, type C2 |
| NPRL2 | nitrogen permease regulator-like 2 (S. cerevisiae) |
| OAT | ornithine aminotransferase |
| OSBPL8 | oxysterol binding protein-like 8 |
| OSTF1 | osteoclast stimulating factor 1 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 |
| PCMT1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase |
| PEG10 | paternally expressed 10 |
| PHKG2 | phosphorylase kinase, gamma 2 (testis) |
| PLA2G15 | phospholipase A2, group XV |
| PLA2G16 | phospholipase A2, group XVI |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 |
| PLIN2 | perilipin 2 |
| POLB | polymerase (DNA directed), beta |
| PROM1 | prominin 1 |
| PRSS2 | protease, serine, 2 (trypsin 2) |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein |
| RAD9A | RAD9 homolog A (S. pombe) |
| RCAN1 | regulator of calcineurin 1 |
| REEP1 | receptor accessory protein 1 |
| RIMS3 | regulating synaptic membrane exocytosis 3 |
| ROGDI | rogdi homolog (Drosophila) |
| RRBP1 | ribosome binding protein 1 |
| RTN2 | reticulon 2 |
| SARAF | store-operated calcium entry-associated regulatory factor |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) |
| SCPEP1 | serine carboxypeptidase 1 |
| SEPW1 | selenoprotein W, 1 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
| SLC46A3 | solute carrier family 46, member 3 |
| SLC9A6 | solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 |
| SNN | stannin |
| SORT1 | sortilin 1 |
| SPAG9 | sperm associated antigen 9 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 |
| STAB1 | stabilin 1 |
| STAR | steroidogenic acute regulatory protein |
| STAT1 | signal transducer and activator of transcription 1, 91kDa |
| STK38 | serine/threonine kinase 38 |
| STXBP1 | syntaxin binding protein 1 |
| TBC1D4 | TBC1 domain family, member 4 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 |
| TKTL1 | transketolase-like 1 |
| TM7SF2 | transmembrane 7 superfamily member 2 |
| TMSB15A | thymosin beta 15a |
| TPST2 | tyrosylprotein sulfotransferase 2 |
| TSPAN13 | tetraspanin 13 |
| TUBB2A | tubulin, beta 2A class IIa |
| TUFT1 | tuftelin 1 |
| TXNIP | thioredoxin interacting protein |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) |
| UGCG | UDP-glucose ceramide glucosyltransferase |
| VAMP7 | vesicle-associated membrane protein 7 |
| VAT1 | vesicle amine transport 1 |
| VCL | vinculin |
| WDR47 | WD repeat domain 47 |
| WDTC1 | WD and tetratricopeptide repeats 1 |
| WFS1 | Wolfram syndrome 1 (wolframin) |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 |
| ZBTB18 | zinc finger and BTB domain containing 18 |
| ZDHHC11 | zinc finger, DHHC-type containing 11 |
| Symbol | Name |
|---|---|
| AKAP8 | A kinase (PRKA) anchor protein 8 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) |
| AKR1C1 | aldo-keto reductase family 1, member C1 |
| AKR1C2 | aldo-keto reductase family 1, member C2 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 |
| ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B |
| ANXA1 | annexin A1 |
| ARGLU1 | arginine and glutamate rich 1 |
| ARL4A | ADP-ribosylation factor-like 4A |
| ATF1 | activating transcription factor 1 |
| ATF5 | activating transcription factor 5 |
| BASP1 | brain abundant, membrane attached signal protein 1 |
| C1R | complement component 1, r subcomponent |
| C1S | complement component 1, s subcomponent |
| CCDC86 | coiled-coil domain containing 86 |
| CCND1 | cyclin D1 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta |
| CFI | complement factor I |
| CFLAR | CASP8 and FADD-like apoptosis regulator |
| COL4A5 | collagen, type IV, alpha 5 |
| COL4A6 | collagen, type IV, alpha 6 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 |
| DIO2 | deiodinase, iodothyronine, type II |
| DNPH1 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 |
| DUSP4 | dual specificity phosphatase 4 |
| EDN1 | endothelin 1 |
| EFS | embryonal Fyn-associated substrate |
| EGFR | epidermal growth factor receptor |
| EMG1 | EMG1 N1-specific pseudouridine methyltransferase |
| EMP3 | epithelial membrane protein 3 |
| EREG | epiregulin |
| EXOSC4 | exosome component 4 |
| FAIM | Fas apoptotic inhibitory molecule |
| FAM57A | family with sequence similarity 57, member A |
| FAM60A | family with sequence similarity 60, member A |
| FOSL1 | FOS-like antigen 1 |
| FOXM1 | forkhead box M1 |
| GABPB1 | GA binding protein transcription factor, beta subunit 1 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 |
| GPX2 | glutathione peroxidase 2 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 |
| GSAP | gamma-secretase activating protein |
| HMBS | hydroxymethylbilane synthase |
| HMGB2 | high mobility group box 2 |
| HOXA10 | homeobox A10 |
| HOXB7 | homeobox B7 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein |
| IFRD2 | interferon-related developmental regulator 2 |
| IGFBP6 | insulin-like growth factor binding protein 6 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa |
| JADE2 | jade family PHD finger 2 |
| KANK1 | KN motif and ankyrin repeat domains 1 |
| KEAP1 | kelch-like ECH-associated protein 1 |
| KIF18B | kinesin family member 18B |
| KRT6A | keratin 6A, type II |
| KRT6B | keratin 6B, type II |
| KRT7 | keratin 7, type II |
| KYNU | kynureninase |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) |
| LHX2 | LIM homeobox 2 |
| LMNB1 | lamin B1 |
| LOC100505650 | uncharacterized LOC100505650 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
| MDK | midkine (neurite growth-promoting factor 2) |
| MECOM | MDS1 and EVI1 complex locus |
| MEIS2 | Meis homeobox 2 |
| MET | MET proto-oncogene, receptor tyrosine kinase |
| METTL3 | methyltransferase like 3 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 |
| MLPH | melanophilin |
| MRPL15 | mitochondrial ribosomal protein L15 |
| MTA1 | metastasis associated 1 |
| NBN | nibrin |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
| NME4 | NME/NM23 nucleoside diphosphate kinase 4 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) |
| NRIP1 | nuclear receptor interacting protein 1 |
| NSMAF | neutral sphingomyelinase (N-SMase) activation associated factor |
| NUP62 | nucleoporin 62kDa |
| PDCD2 | programmed cell death 2 |
| PDGFA | platelet-derived growth factor alpha polypeptide |
| PDLIM4 | PDZ and LIM domain 4 |
| PFAS | phosphoribosylformylglycinamidine synthase |
| PFDN4 | prefoldin subunit 4 |
| PIGB | phosphatidylinositol glycan anchor biosynthesis, class B |
| PLK1 | polo-like kinase 1 |
| PMF1 | polyamine-modulated factor 1 |
| PON2 | paraoxonase 2 |
| PTX3 | pentraxin 3, long |
| PUS7 | pseudouridylate synthase 7 (putative) |
| RAB11FIP2 | RAB11 family interacting protein 2 (class I) |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 |
| RBMX | RNA binding motif protein, X-linked |
| RCN1 | reticulocalbin 1, EF-hand calcium binding domain |
| RIN2 | Ras and Rab interactor 2 |
| RPIA | ribose 5-phosphate isomerase A |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) |
| SENP6 | SUMO1/sentrin specific peptidase 6 |
| SFRP1 | secreted frizzled-related protein 1 |
| SLC35F2 | solute carrier family 35, member F2 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 |
| SMAD3 | SMAD family member 3 |
| SNRPD1 | small nuclear ribonucleoprotein D1 polypeptide 16kDa |
| SNRPE | small nuclear ribonucleoprotein polypeptide E |
| SPRR1A | small proline-rich protein 1A |
| SPRR1B | small proline-rich protein 1B |
| SPRY2 | sprouty homolog 2 (Drosophila) |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein |
| TCERG1 | transcription elongation regulator 1 |
| TFAP2A | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) |
| TGIF1 | TGFB-induced factor homeobox 1 |
| TGM2 | transglutaminase 2 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) |
| TM4SF1 | transmembrane 4 L six family member 1 |
| TMX1 | thioredoxin-related transmembrane protein 1 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 |
| TP53I3 | tumor protein p53 inducible protein 3 |
| TRD | T cell receptor delta locus |
| TRIM16 | tripartite motif containing 16 |
| TSKU | tsukushi, small leucine rich proteoglycan |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 |
| UFC1 | ubiquitin-fold modifier conjugating enzyme 1 |
| UPK1B | uroplakin 1B |
| USP22 | ubiquitin specific peptidase 22 |
| WDR43 | WD repeat domain 43 |
| WEE1 | WEE1 G2 checkpoint kinase |
| WNT5A | wingless-type MMTV integration site family, member 5A |
| ZBTB20 | zinc finger and BTB domain containing 20 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 |
| ZNF532 | zinc finger protein 532 |
