BRD-K69840642_HDAC6 inhibitor ISOX_EFO27_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

232 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_EFO27_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABAT 4-aminobutyrate aminotransferase
ACOT7 acyl-CoA thioesterase 7
ACTA2 actin, alpha 2, smooth muscle, aorta
ADCY9 adenylate cyclase 9
ADD3 adducin 3 (gamma)
ALDOC aldolase C, fructose-bisphosphate
ARF3 ADP-ribosylation factor 3
BSG basigin (Ok blood group)
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
CCND3 cyclin D3
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CECR1 cat eye syndrome chromosome region, candidate 1
CHGB chromogranin B
CLIC4 chloride intracellular channel 4
COBL cordon-bleu WH2 repeat protein
COL10A1 collagen, type X, alpha 1
COL3A1 collagen, type III, alpha 1
CORO1A coronin, actin binding protein, 1A
CST6 cystatin E/M
CTR9 CTR9, Paf1/RNA polymerase II complex component
CXCR4 chemokine (C-X-C motif) receptor 4
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EDN3 endothelin 3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPAS1 endothelial PAS domain protein 1
FAM117A family with sequence similarity 117, member A
G6PD glucose-6-phosphate dehydrogenase
GLRX glutaredoxin (thioltransferase)
GNAS GNAS complex locus
GNS glucosamine (N-acetyl)-6-sulfatase
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H1C histone cluster 1, H1c
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
KCTD12 potassium channel tetramerization domain containing 12
KCTD5 potassium channel tetramerization domain containing 5
LGALS3 lectin, galactoside-binding, soluble, 3
LONP2 lon peptidase 2, peroxisomal
LTA4H leukotriene A4 hydrolase
MAP7 microtubule-associated protein 7
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MGP matrix Gla protein
MKNK1 MAP kinase interacting serine/threonine kinase 1
MNAT1 MNAT CDK-activating kinase assembly factor 1
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MTUS1 microtubule associated tumor suppressor 1
NCF2 neutrophil cytosolic factor 2
NEU1 sialidase 1 (lysosomal sialidase)
NINJ2 ninjurin 2
NLRP2 NLR family, pyrin domain containing 2
NPR3 natriuretic peptide receptor 3
NYNRIN NYN domain and retroviral integrase containing
OPN3 opsin 3
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PLA2G15 phospholipase A2, group XV
PLA2G16 phospholipase A2, group XVI
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RGS10 regulator of G-protein signaling 10
RGS2 regulator of G-protein signaling 2
ROGDI rogdi homolog (Drosophila)
SCPEP1 serine carboxypeptidase 1
SEPT6 septin 6
SFTPB surfactant protein B
SFTPC surfactant protein C
SKAP2 src kinase associated phosphoprotein 2
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
STXBP1 syntaxin binding protein 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TANK TRAF family member-associated NFKB activator
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP3 TIMP metallopeptidase inhibitor 3
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VGLL1 vestigial-like family member 1
VWA5A von Willebrand factor A domain containing 5A
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF586 zinc finger protein 586
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADGRE5 adhesion G protein-coupled receptor E5
ADM adrenomedullin
ADORA2B adenosine A2b receptor
AK4 adenylate kinase 4
AKAP8 A kinase (PRKA) anchor protein 8
ALCAM activated leukocyte cell adhesion molecule
ANXA10 annexin A10
ATF5 activating transcription factor 5
AUTS2 autism susceptibility candidate 2
BEX1 brain expressed, X-linked 1
BIN1 bridging integrator 1
BMP2 bone morphogenetic protein 2
C1R complement component 1, r subcomponent
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCND1 cyclin D1
CD58 CD58 molecule
CDC25B cell division cycle 25B
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHRDL1 chordin-like 1
CKAP4 cytoskeleton-associated protein 4
CLEC2B C-type lectin domain family 2, member B
COL14A1 collagen, type XIV, alpha 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
EMP3 epithelial membrane protein 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO2 enolase 2 (gamma, neuronal)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F12 coagulation factor XII (Hageman factor)
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GPRC5C G protein-coupled receptor, class C, group 5, member C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXA10 homeobox A10
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP6 insulin-like growth factor binding protein 6
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KCNK1 potassium channel, two pore domain subfamily K, member 1
KEAP1 kelch-like ECH-associated protein 1
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIAA0368 KIAA0368
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
LAMB1 laminin, beta 1
LOX lysyl oxidase
LPL lipoprotein lipase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MB myoglobin
MDK midkine (neurite growth-promoting factor 2)
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MICALL1 MICAL-like 1
MLPH melanophilin
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NEFL neurofilament, light polypeptide
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
PAX8 paired box 8
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLK1 polo-like kinase 1
PLTP phospholipid transfer protein
PPAP2B phosphatidic acid phosphatase type 2B
PTX3 pentraxin 3, long
QKI QKI, KH domain containing, RNA binding
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL10 ribosomal protein L10
RPL37A ribosomal protein L37a
RREB1 ras responsive element binding protein 1
S100A10 S100 calcium binding protein A10
SALL1 spalt-like transcription factor 1
SCD5 stearoyl-CoA desaturase 5
SCRN1 secernin 1
SFRP1 secreted frizzled-related protein 1
SLC35F2 solute carrier family 35, member F2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMAD1 SMAD family member 1
SNRPE small nuclear ribonucleoprotein polypeptide E
SOX9 SRY (sex determining region Y)-box 9
SPAG4 sperm associated antigen 4
SPRY2 sprouty homolog 2 (Drosophila)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF1 trefoil factor 1
TLR4 toll-like receptor 4
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TPBG trophoblast glycoprotein
TPM1 tropomyosin 1 (alpha)
TRAF5 TNF receptor-associated factor 5
TSC22D1 TSC22 domain family, member 1
TSKU tsukushi, small leucine rich proteoglycan
WEE1 WEE1 G2 checkpoint kinase
ZHX2 zinc fingers and homeoboxes 2
ZIC1 Zic family member 1
Funding